Effects of chromium picolinate supplementation on insulin sensitivity, serum lipids, and body weight in dexamethasone-treated rats

Anti-hyperglycemic Activity of Chromium(III) Malate Complex in Alloxan-Induced Diabetic Rats

“…In the fed state, [Cr 2 (LMA) 3 ] administrated rats showed sign of body mass gaining when compared to the diabetic controls, although there was no significant increase of the level of body mass among them. The similar results were reported in previous literature [25] which found that there was not significantly different body mass between the chromium picolinate-treated dexamethasone-treated rats and dexamethasone-treated rats for 14 days. Table 1).…”

Effect of Tectona grandis Linn. on dexamethasone-induced insulin resistance in mice

“…Pharmacological doses of glucocorticoids induce ob gene expression in rat adipocyte tissues within 24 h which is followed by complex metabolic changes like hyperleptinemia, resulting in decrease in food consumption, reduction in body weight with enhanced blood glucose and triglyceride levels (Kim et al, 2002;Shalam et al, 2006). As expected, in the present study, dexamethasone group showed reduction in body weight, while TG and Pioglitazone treatment inhibited dexamethasone-induced reduction in body weight and showed marginal increase in body weight.…”

Effects of chromium picolinate on glucose uptake in insulin-resistant 3T3-L1 adipocytes involve activation of p38 MAPK

“…Thereafter, various studies reported that patients deficient in Cr after long-term parenteral nutrition displayed symptoms or complications of type 2 diabetes (e.g., peripheral neuropathy, impaired glucose tolerance and elevated plasma free fatty acids) [12]. Cr was shown to play a role in the control of type 2 diabetes, steroid-induced diabetes and glucose intolerance [13][14][15]. Improved bioavailability of low-molecular-weight (LMW)-organic Cr complexes and the identification of the biologically active form of Cr as a complex with an oligopeptide promoted the design and evaluation of LMW-organic Cr complexes as therapeutic drugs for treating type 2 diabetes [16,17].…”