Effects of concurrent training on inflammatory markers and expression of CD4, CD8, and HLA-DR in overweight and obese adults

Abstract

The number of people who are overweight or obese is increasing worldwide and the quality of life of these people can be affected by their condition. Physical training has been studied in obese patients and is correlated with low-grade inflammation and alterations in the immune system. This study investigated the effect of concurrent training on anthropometric, inflammatory, and immunological parameters in overweight and obese adults. Fourteen sedentary volunteers (men and women) with a body mass index between 25 kg/m 2 and 39.9 kg/m 2 from Porto Alegre, Brazil attended a 12-week course of concurrent training. We analyzed: prior to and after training, anthropometric parameters, cytokine serum levels (interleukin 6, tumor necrosis factor a, interferon g, interleukin 17A and interleukin 10; measured by enzyme-linked immunosorbent assay), high-sensitive C reactive protein (measured by turbidimetry), and the frequency of T lymphocytes and monocytes (CD3þCD4þ, CD3þCD8þ, and HLA-DRþ) in peripheral blood (measured by flow cytometry). The sample consisted of ten women and four men with a mean ± SD age of 47.58 ± 3.01 years. After 12 weeks of training we observed a reduction in body weight, body mass index, waist, abdomen, and hip circumferences, the percentage mass of fat, and an increase in the time taken to reach exhaustion (p < 0.05). The participants had increased frequencies of CD3þCD4þ and CD3þCD8þ T lymphocytes and a reduction in the frequencies of HLA-DRþ monocytes (p < 0.05). Interestingly, the levels of tumor necrosis factor a and high-sensitive C reactive protein increased (p < 0.05). Our data suggest that concurrent training can improve body composition as well as increasing T cell proliferation in overweight and obese patients. However, the progression of the exercises can be physiologically stressful to these patients, as demonstrated by the inflammatory markers.

Acute and chronic effects of High Intensity Interval Training on inflammatory and oxidative stress markers of postmenopausal obese women

“…The contemporary literature suggests that exercise has systemic effects on immune function that can counteract the chronic low grade inflammation induced by physical inactivity and obesity . Although reductions in body fatness are widely recognized to induce some of the anti‐inflammatory effects of exercise training, changes in cellular immune function are independently of changes in body fat .…”

The Effect of All-Extremity High-Intensity Interval Training on Plasma Pentraxin 3 in Young Overweight and Obese Women

“…IL10 is an anti-inflammatory cytokine which is impaired in obesity (26). Here, IL10 remained unchanged after all ex.…”

Impact of eight weeks of concurrent training on obesity-related biochemical parameters and cardiometabolic risk factors: a case report

“…Interestingly, Colato et al, 37 found increased levels of TNF-α and CRP after 12 weeks of concurrent training in 41 overweight / obese patients. Although there was an improvement in body composition and an increase in T-cell proliferation, the authors emphasize that exercise progression may be physiologically stressful for these patients, as demonstrated by inflammatory markers.…”