Effects of Cordyceps sinensis on dimethylnitrosamine-induced liver fibrosis in rats

Abstract

Cordyceps sinensis can considerably relieve the liver fibrosis, and the mechanism may be related to promoting the degradation of the collagens.

A comparison of chemical composition, bioactive components and antioxidant activity of natural and cultured Cordyceps sinensis

“…A specific product, called "JingShui-Bao" capsule in China, was derived from the strain Paecilomyces hepiali isolated from wild C. sinensis in Qinghai province. Beneficial effects of this cultured C. sinensis have been demonstrated to relieve the liver and renal fibrosis in rats (Guo et al, 2012;Li, Liu, Xiong, & Xu, 2006) and improve glucose metabolism and insulin sensitivity (Zhao et al, 2002).…”

Cordyceps sinensis protects against liver and heart injuries in a rat model of chronic kidney disease: a metabolomic analysis

“…As we reported previously, the renoprotective efficacy of C sinensis was confirmed by its ameliorating metabolic abnor-www.nature.com/aps Liu X et al Acta Pharmacologica Sinica npg malities in the kidneys of rats with CKD [9] . Additionally, C sinensis has also been identified to play significant roles in the protection of liver [10] and heart [11,12] tissue from pathological impairments; thus, we hypothesized that C sinensis could also improve the metabolic function of the extrarenal organs, such as the heart and liver, to achieve its therapeutic effects on the kidney.…”

Cordyceps as an Herbal Drug

“…First, cordyceps has a potential enhancing effect on the immunological function of patients suffering from chronic hepatitis B (Gong, Wang, and Tang 2000) and from posthepatic cirrhosis (Zhu and Liu 1992). Second, cordyceps was shown to inhibit and reverse liver fibrosis via degradation of collagen in rats with liver cirrhosis induced by dimethylnitrosamine (Li et al 2006a;Wang, Liu, and Tang 2008) and CD126 in human fibroblasts (Li and Tsim 2004), and decrease expression of transforming growth factor-β and platelet-driven growth factor (Liu and Shen 2003). Third, cordyceps decreased lipid peroxide levels in serum and hepatic tissue, and lowered serum TNF-α in bacillus calmette guerin plus LPS-induced liver injury in mice (Zeng, Tang, and Yuan 2001).…”