Effects of Curcumin and Pentagamavunon-0 Against Dengue-2 Virus Infection in Vero Cells; an in Vitro Study

Marbawati, Dewi; Umniyati, Sitti Rahmah

doi:10.1016/j.proenv.2015.01.033

Cited by 9 publications

(6 citation statements)

References 7 publications

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“…The antiviral and antitumor effectiveness and safety of curcumin were also tested in vivo [42] [43]. Previous studies have investigated the effects of treating cells with curcumin on HSV-1 infection [35] or treating HSV-2 virions with curcumin [36]. This study is unique in investigating the effect on the infection cycle of curcumin-treated HSV-1 and HSV-2 virions.…”

Section: Discussionmentioning

confidence: 99%

“…This compound is demonstrated to contain antioxidant, anti-inflammatory, and antitumor properties [25]- [28]. Curcumin has also been demonstrated to have antiviral properties against hepatits B, hepatits C, influenza, enterovirus 71, and dengue virus [29]- [35]. Additionally, treatment of cells with curcumin has been demonstrated to inhibit immediate-early gene expression of HSV-1 [36].…”

Section: Introductionmentioning

confidence: 99%

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Inhibition of Curcumin-Treated Herpes Simplex Virus 1 and 2 in Vero Cells

Flores¹,

Lee²,

Adams³

2016

AiM

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The purpose of this study was to investigate the effect of curcumin-treated Herpes simplex virus-1 (HSV-1) and Herpes simplex virus-2 (HSV-2) virions in cultured Vero cells. Previous studies have indicated that curcumin, a polyphenol extracted from the plant Curcuma longa, has demonstrated antiviral properties against a variety of viruses. After establishing the maximum non-cytotoxic concentrations of curcumin on Vero cells, HSV-1 and HSV-2 virions were treated with varying concentrations of curcumin. The effect on infectivity was determined by antiviral assays, using WST-1, plaque assays, adsorption and penetration assays. Treating HSV-1 and HSV-2 viruses with curcumin, at a concentration of 30 µM, reduces the production of infectious HSV-1 and HSV-2 virions in cultured Vero cells by interfering with the adsorption process. These results support the potential of curcumin to be used as a therapeutic agent to reduce the transmission of HSV-1 and HSV-2.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Inhibition of Curcumin-Treated Herpes Simplex Virus 1 and 2 in Vero Cells

Flores¹,

Lee²,

Adams³

2016

AiM

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“…Nanocurcumin improved cell uptake in comparison to curcumin [84,85]. Curcumin chitosan nanocomposite exhibited a better inhibition of entrance and replication of HCV in human hepatoma cells than curcumin [84].…”

Section: Formulation and Functional Improvement Of Curcuminmentioning

confidence: 92%

Anti-Viral Potential and Modulation of Nrf2 by Curcumin: Pharmacological Implications

Rahban

Rezaei

Mazaheri³

et al. 2020

Antioxidants

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Nuclear factor erythroid 2-related factor 2 (Nrf2) is an essential transcription factor that maintains the cell’s redox balance state and reduces inflammation in different adverse stresses. Under the oxidative stress, Nrf2 is separated from Kelch-like ECH-associated protein 1 (Keap1), which is a key sensor of oxidative stress, translocated to the nucleus, interacts with the antioxidant response element (ARE) in the target gene, and then activates the transcriptional pathway to ameliorate the cellular redox condition. Curcumin is a yellow polyphenolic curcuminoid from Curcuma longa (turmeric) that has revealed a broad spectrum of bioactivities, including antioxidant, anti-inflammatory, anti-tumor, and anti-viral activities. Curcumin significantly increases the nuclear expression levels and promotes the biological effects of Nrf2 via the interaction with Cys151 in Keap1, which makes it a marvelous therapeutic candidate against a broad range of oxidative stress-related diseases, including type 2 diabetes (T2D), neurodegenerative diseases (NDs), cardiovascular diseases (CVDs), cancers, viral infections, and more recently SARS-CoV-2. Currently, the multifactorial property of the diseases and lack of adequate medical treatment, especially in viral diseases, result in developing new strategies to finding potential drugs. Curcumin potentially opens up new views as possible Nrf2 activator. However, its low bioavailability that is due to low solubility and low stability in the physiological conditions is a significant challenge in the field of its efficient and effective utilization in medicinal purposes. In this review, we summarized recent studies on the potential effect of curcumin to activate Nrf2 as the design of potential drugs for a viral infection like SARS-Cov2 and acute and chronic inflammation diseases in order to improve the cells’ protection.

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“…Curcumin and PGV-0 were tested for immunocytochemistry for both incubation periods (1 and 3 days) showed no remarkable changes and the Reverse transcriptase-Polymerase chain reaction test (RT-PCR) showed that the PGV -0 is more potent antiviral agent than curcumin. 19 Carneiro et al, 2017 investigated the molecular docking and characterisation of curcumin and monodimethylcurcumin ligands, as well as the dengue virus 5B1C protein (PDB code) (DENV-4). And these molecular docking results showed a correlation with the activity values of the compounds, which confirmed the importance of the residues for DENV-4 activity.…”

Section: Dengue Virusmentioning

confidence: 99%