Effects of epidural administration of morphine and buprenorphine on the minimum alveolar concentration of isoflurane in cats

Pypendop, Bruno H.; Pascoe, Peter J; Ilkiw, Jan E.

doi:10.2460/ajvr.67.9.1471

Cited by 32 publications

(21 citation statements)

References 36 publications

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“…It is known that a single epidural injection produces local damages in a tissue that can develop fibrosis, as a result it can affect the technique and distribution of drugs. 10 The current study did not have difficulties during the second and third epidural approach. However, the consequence of performing consecutive epidural injections on a drug's effect and distribution are not known.…”

Section: Discussionmentioning

confidence: 67%

Comparison between the analgesic effects of morphine and tramadol delivered epidurally in cats receiving a standardized noxious stimulation

Castro

Silva

Shih

et al. 2009

Journal of Feline Medicine and Surgery

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This study compared the analgesic effects of epidural tramadol versus morphine in six healthy cats. Under general anesthesia, each cat received an epidural injection of saline 0.22 ml/kg (control treatment, CT), tramadol 1mg/kg (tramadol treatment, TT), or morphine 0.1mg/kg (morphine treatment, MT). After cats had recovered from anesthesia a simple descriptive scale (SDS), visual analog scale (VAS) and physiological parameters (respiratory and heart rate) were used to assess analgesia level to a noxious stimulus (base of the tail skin fold clamping) at 1, 2, 3, 4, 6, 8, 10, and 12h post-epidural. Group TT had a higher SDS and VAS score when compared to MT at 8, 10 and 12h post-epidural. CT had higher SDS and VAS score at all time points when compared to TT and MT. In conclusion both morphine and tramadol provided analgesia in this model for the first 6h; with epidural morphine resulting in longer lasting analgesia when compared to tramadol.

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Section: Discussionmentioning

confidence: 67%

Comparison between the analgesic effects of morphine and tramadol delivered epidurally in cats receiving a standardized noxious stimulation

Castro

Silva

Shih

et al. 2009

Journal of Feline Medicine and Surgery

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“…In addition, the epidural route might reduce the magnitude of the 25‐ to 50‐fold difference in potency between buprenorphine and morphine as documented by others following systemic administration (Chrubasik et al. 1987; Roughan & Flecknell 2002; Pypendop et al. 2006).…”

Section: Discussionmentioning

confidence: 97%

A comparison of epidural buprenorphine plus detomidine with morphine plus detomidine in horses undergoing bilateral stifle arthroscopy

Fischer

Ludders

Asakawa

et al. 2009

Veterinary Anaesthesia and Analgesia

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“…End‐tidal isoflurane concentration was maintained at 2%, unless spontaneous movement was observed, in which case the isoflurane concentration was increased. Two percent was selected because it approximates the minimum alveolar concentration of isoflurane in cats determined in several studies in our laboratory (Pypendop et al ., , ; Barter et al ., ; Pypendop & Ilkiw, ; Reid et al ., ; Escobar et al ., ).…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetics of fentanyl, alfentanil, and sufentanil in isoflurane‐anesthetized cats

Pypendop

Brosnan

Majewski-Tiedeken

et al. 2013

Vet Pharm & Therapeutics

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The aim of this study was to compare the pharmacokinetics of fentanyl, alfentanil, and sufentanil in isoflurane-anesthetized cats. Six adult cats were used. Anesthesia was induced and maintained with isoflurane in oxygen. End-tidal isoflurane concentration was set at 2% and adjusted as required due to spontaneous movement. Fentanyl (10 μg/kg), alfentanil (100 μg/kg), or sufentanil (1 μg/kg) was administered intravenously as a bolus, on separate days. Blood samples were collected immediately before and for 8 h following drug administration. Plasma drug concentration was determined using liquid chromatography/mass spectrometry. Compartment models were fitted to concentration-time data. A 3-compartment model best fitted the concentration-time data for all drugs, except for 1 cat in the sufentanil group (excluded from analysis). The volume of the central compartment and the volume of distribution at steady-state (L/kg) [mean ± SEM (range)], the clearance (mL/min/kg) [harmonic mean ± pseudo-SD (range)], and the terminal half-life (min) [median (range)] were 0.25 ± 0.04 (0.09-0.34), 2.18 ± 0.16 (1.79-2.83), 18.6 ± 5.0 (15-29.8), and 151 (115-211) for fentanyl; 0.10 ± 0.01 (0.07-0.14), 0.89 ± 0.16 (0.68-1.83), 11.6 ± 2.6 (9.2-15.8), and 144 (118-501) for alfentanil; and 0.06 ± 0.01 (0.04-0.10), 0.77 ± 0.07 (0.63-0.99), 17.6 ± 4.3 (13.9-24.3), and 54 (46-76) for sufentanil. Differences in clearance and volume of distribution result in similar terminal half-lives for fentanyl and alfentanil, longer than for sufentanil.

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Effects of epidural administration of morphine and buprenorphine on the minimum alveolar concentration of isoflurane in cats

Cited by 32 publications

References 36 publications

Comparison between the analgesic effects of morphine and tramadol delivered epidurally in cats receiving a standardized noxious stimulation

Comparison between the analgesic effects of morphine and tramadol delivered epidurally in cats receiving a standardized noxious stimulation

A comparison of epidural buprenorphine plus detomidine with morphine plus detomidine in horses undergoing bilateral stifle arthroscopy

Pharmacokinetics of fentanyl, alfentanil, and sufentanil in isoflurane‐anesthetized cats

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