Effects of erythritol on endothelial function in patients with type 2 diabetes mellitus: a pilot study

Flint, Nir; Hamburg, Naomi M.; Holbrook, Monika; Dorsey, Pamela G.; LeLeiko, Rebecca M.; Berger, Alvin; Cock, Peter de; Bosscher, Douwina; Vita, Joseph A.

doi:10.1007/s00592-013-0534-2

Cited by 31 publications

(42 citation statements)

References 5 publications

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“…The effects in animal studies include antidiabetic properties such as improved pancreatic islet morphology and blood glucose-lowering effects in heathy and diabetic rats (17,27). In pilot studies of patients with diabetes, daily intake of 36 g of erythritol resulted in improvement of endothelial function and reduced central aortic stiffness (9). Taken together, these studies support the concept that polyols, especially erythritol, might be attractive nonnutritive sweeteners for the dietary management of diabetes mellitus.…”

mentioning

confidence: 64%

Gut hormone secretion, gastric emptying, and glycemic responses to erythritol and xylitol in lean and obese subjects

Wölnerhanssen

Cajacob

Keller

et al. 2016

American Journal of Physiology-Endocrinology and Metabolism

110

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mentioning

confidence: 64%

Gut hormone secretion, gastric emptying, and glycemic responses to erythritol and xylitol in lean and obese subjects

Wölnerhanssen

Cajacob

Keller

et al. 2016

American Journal of Physiology-Endocrinology and Metabolism

110

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“…Other prospective studies provide additional evidence for an association between regular SSB intake and the development of hypertension [ 24 ], whereas some demonstrated that blood pressure can be successfully lowered by decreasing SSB consumption [ 49 ]. In support, some showed beneficial effects of artificial sweetener consumption (erythritol) on reducing arterial stiffness and antihypertensive effects in the context of T2DM [ 55 ]. Although most studies detect a positive association between SSB consumption and hypertension, the adjusted risk is not always significant [ 17 , 24 ], and it is therefore essential that more robust interventional studies be initiated to confirm such findings.…”

Section: Resultsmentioning

confidence: 99%

Frequent Sugar-Sweetened Beverage Consumption and the Onset of Cardiometabolic Diseases: Cause for Concern?

Deshpande

Mapanga

Essop

2017

Journal of the Endocrine Society

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The incidence of noncommunicable diseases is on the rise and poses a major threat to global public health. This is in parallel to a steady increase in worldwide intake of sugar-sweetened beverages (SSBs) among all age groups. As several studies demonstrated a controversial relationship between SSB consumption and the metabolic syndrome (MetS), this mini-review focuses on links between its intake and (1) MetS, (2) prediabetes/type 2 diabetes mellitus (T2DM), and (3) hypertension. A detailed search for clinical and observational studies published during the past 10 years was conducted using key terms that link SSBs to the MetS, T2DM, and hypertension. Here we excluded all meta-analyses and also literature that solely focused on obesity. The analysis revealed that most epidemiological studies strongly show that frequent SSB intake contributes to the onset of the MetS in the longer term. Some of the findings also show that regular SSB intake can alter glucose handling and insulin sensitivity, thereby contributing to the development of the MetS and T2DM. There is also evidence that frequent SSB intake (and particularly fructose) is linked to hypertension and well-known cardiovascular disease risk factors. However, some studies report on the lack of negative effects as a result of SSB consumption. Because of this discrepancy, we propose that well-designed long-term clinical studies should further enhance our understanding regarding the links between SSB consumption and the onset of cardiometabolic diseases.

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“…It is assumed that endothelium is not compromised by erythritol in non-diabetic subjects, but in diabetic subjects where endothelium is under diabetic stress, erythritol can transfer a range of damage and dysfunction parameters to a safer side, as in vitro , ex vivo and in vivo studies report [ 148 , 150 , 151 ]. Erythritol can also be regarded as a substance with a beneficial impact on the endothelium under high-glucose conditions by contributing to avoid or delay the onset of diabetic complications [ 152 ]. The erythritol attribute has minor effects on several targets and can also prove beneficial.…”

Section: Health Impactsmentioning

confidence: 99%

“…The option would be to use a substance like erythritol with moderate protective effects. Erythritol is not only valuable, but should be considered a recommended sugar replacement for the rapidly increasing numbers of people with diabetes or prediabetes to reduce their chances of developing diabetic complications [ 152 , 153 ].…”

Section: Health Impactsmentioning

confidence: 99%

Natural Sweeteners: The Relevance of Food Naturalness for Consumers, Food Security Aspects, Sustainability and Health Impacts

Saraiva

Carrascosa

Raheem

et al. 2020

IJERPH

127

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At a moment when the population is increasingly aware and involved in what it eats, both consumers and the food sector are showing more interest in natural foods. This review work discusses, addresses and provides details of the most important aspects of consumer’s perceptions of and attitudes to natural foods and in-depth research into natural sweeteners. It also includes issues about their use and development as regards health impacts, food security and sustainability. In line with our main research outcome, we can assume that consumers are very keen on choosing foods with clean labelling, natural ingredients, preferably with other functional properties, without the loss of taste. In response to such a phenomenon, the food industry offers consumers alternative natural sweeteners with the advantage of added health benefits. It is noteworthy that Nature is a superb source of desirable substances, and many have a sweet taste, and many still need to be studied. Finally, we must stress that being natural does not necessarily guarantee market success.

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Effects of erythritol on endothelial function in patients with type 2 diabetes mellitus: a pilot study

Cited by 31 publications

References 5 publications

Gut hormone secretion, gastric emptying, and glycemic responses to erythritol and xylitol in lean and obese subjects

Gut hormone secretion, gastric emptying, and glycemic responses to erythritol and xylitol in lean and obese subjects

Frequent Sugar-Sweetened Beverage Consumption and the Onset of Cardiometabolic Diseases: Cause for Concern?

Natural Sweeteners: The Relevance of Food Naturalness for Consumers, Food Security Aspects, Sustainability and Health Impacts

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