Effects of fetal and neonatal exposure to nicotine on blood pressure and perivascular adipose tissue function in adult life

Maternal nicotine exposure during gestation and lactation induces kidney injury and fibrosis in rat offspring

“…This effect was less obvious on postnatal day 21. The effect of nicotine on kidney structure was related to the dosage and duration of nicotine exposure and the offspring age (5,7,8). Gao et al (5) injected nicotine (1 mg/kg/day) to female WKY rats 2 wk before mating until weaning and found comparable kidney weight, total number of nephrons, and glomerular size in rat offspring at the age of 26 wk.…”

Nicotine and the kidney: Mr. Hyde, and perhaps some Dr. Jekyll

“…However, prenatal exposure to nicotine resulted in increased BP 14 wk after birth in some but not all wild rat strains and early after birth in spontaneously hypertensive rats (4).…”

9th International Symposium on Resistance Arteries (ISRA)

“…Similarly Tare concluded that prenatal glucocorticoid exposure resulted in endothelial dysfunction and pro-vasoconstrictor thus predisposing the offspring to lifelong cardiovascular dysfunction [54]. Lee described the detrimental effects of nicotine exposure in the fetus and neonate on perivascular adipose tissue (PVAT) function that resulted in a reduction in blood pressure lowering contribution of PVAT [53]. .…”

“…Van Bavel tolerance to an ischemia/reperfusion event [51]. Leading on from this presentation several papers examined the effects of factors often found in the gestational environment, including alcohol [52], nicotine [53] and glucocorticoids [54], on vascular function of the offspring. Parkington reported that fetuses exposed to alcohol showed marked increases in arterial stiffness with extrapolations to large vessels thus suggesting that children with fetal alcohol syndrome would be more susceptible to atherosclerosis [52].…”