Effects of gamma-decanolactone on seizures induced by PTZ-kindling in mice

Oliveira, Paulo Alexandre de; Lino, Felipe Luis; Cappelari, Shandale Emanuele; Brum, Lucimar Filot da Silva; Picada, Jaqueline Nascimento; Pereira, Patrı́cia

doi:10.1007/s00221-008-1295-y

Cited by 30 publications

(15 citation statements)

References 22 publications

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“…They also compared the anticonvulsant activities of linalool enantiomers in PTZ, PTX, and MES models and demonstrated that (R)‐(‐)‐linalool was more potent than its enantiomeric form . The administration of γ‐decanolactone at a dose of 0.3 g/kg showed anticonvulsant properties and antiepileptogenic effects in the PTZ‐kindling model, which could also decrease the DNA damage in brain tissue both at 0.1 and 0.3 g/kg . Isopulegol, the product by cyclization of citronellol, seems to interact with a different target.…”

Section: Medicinal Compounds With Antiepileptic/anticonvulsant Activimentioning

confidence: 99%

Medicinal compounds with antiepileptic/anticonvulsant activities

et al. 2013

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SUMMARYObjective: Epilepsy is a serious neural disease that affects around 50 million people all over the world. Although for the majority patients with epilepsy, seizures are well controlled by currently available antiepileptic drugs (AEDs), there are still >30% of patients suffered from medically refractory epilepsy and approximately 30-40% of all epileptic patients affected by numerous side effects and seizure resistance to the current AEDs. Therefore, many researchers try to develop novel approaches to treat epilepsy, for example, to discover new antiepileptic constituents from herbal medicines. Although there are already several reviews on phytotherapy in epilepsy, most of them placed emphasis on the plant crude extracts or their isolated fractions, not pure active compounds derived from herbal medicines. This article aims to review components in herbal medicines that have shown antiepileptic or anticonvulsant properties. Methods: We searched online databases and identified articles using the preset searching syntax and inclusion criteria. The active medicinal compounds that have shown anticonvulsant or antiepileptic activity were included and classified according to structural types. Results: We have reviewed herein the active constituents including alkaloids, flavonoids, terpenoids, saponins, and coumarins. The screening models, the seizures-inducing factors and response, the effective dose, the potential mechanisms, as well as the structure-activity relationships in some of these active components have also been discussed. Significance: The in vitro and in vivo experimental data reviewed in this paper would supply the basic science evidence for research and development of novel AEDs from medicinal plants.

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Section: Medicinal Compounds With Antiepileptic/anticonvulsant Activimentioning

confidence: 99%

Medicinal compounds with antiepileptic/anticonvulsant activities

et al. 2013

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“…Several studies describe its validity and application to study seizure, underlying the course of seizure and testing of anticonvulsant drugs. Kindling refers to a phenomenon in which generalised seizures are developed following repeated administration of subconvulsive electrical or chemical stimuli due to progressive intensification of seizure activity (Ali et al 2005;de Oliveira et al 2008). Kindling induced by PTZ is extensively used as a laboratory model of human partial complex epilepsy (Mason and Cooper 1972;Corda et al 1990).…”

Section: Introductionmentioning

confidence: 99%

“…Epilepsy is one of the commonest neurological disorders of the brain, affecting approximately 1% of the population worldwide (Dhir et al 2005;de Oliveira et al 2008). The pathogenesis of neuronal damage in response to seizure has been widely studied.…”

Section: Introductionmentioning

confidence: 99%

Anticonvulsant and antioxidant actions of trimetazidine in pentylenetetrazole-induced kindling model in mice

Jain

Bharal

Khurana

et al. 2011

Naunyn-Schmied Arch Pharmacol

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The present study was carried out to investigate the effect of trimetazidine on the course of pentylenetetrazole (PTZ)-induced chemical kindling and oxidative stress markers in PTZ-kindled mice. Kindling was induced by repeated injections of a subconvulsive dose of PTZ (30 mg⁄kg, i.p.) on alternate days for 5 weeks or until stage 4 of the seizure score was evoked on three consecutive administrations. Trimetazidine was administered daily in three doses (5, 10 and 20 mg/kg) per orally (p.o.) along with alternate-day PTZ. Following PTZ kindling, oxidative stress parameters, i.e. levels of malondialdehyde (MDA) and reduced glutathione (GSH), were assessed in isolated homogenized whole brain tissue. The results showed that PTZ treatment progressively increased the seizure score in control mice. Biochemical analysis revealed a significant increase in MDA levels and decreased GSH levels in the brain homogenate of PTZ-kindled mice. Daily treatment with trimetazidine in doses of 10 and 20 mg/kg significantly decreased the PTZ-induced seizure score. However, a low dose of trimetazidine (5 mg/kg) failed to improve the seizure score. Pretreatment of trimetazidine in all doses showed an ameliorating effect on biochemical alteration induced by PTZ treatment. The results of the present study indicate the potential anticonvulsant activity of trimetazidine against PTZ-induced kindling in mice.

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“…Gama-decanolactone is a monoterpene that acts on the central nervous system as anticonvulsant and hypnotic [211]. Gama-decanolactone has neuroprotective effect against seizures induced by isoniazid and 4-aminopyridine, but not by picrotoxin.…”

Section: Gamma-decanolactonementioning

confidence: 99%

Anticonvulsant Essential Oils and Their Relationship with Oxidative Stress in Epilepsy

et al. 2019

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Epilepsy is a most disabling neurological disorder affecting all age groups. Among the various mechanisms that may result in epilepsy, neuronal hyperexcitability and oxidative injury produced by an excessive formation of free radicals may play a role in the development of this pathology. Therefore, new treatment approaches are needed to address resistant conditions that do not respond fully to current antiepileptic drugs. This paper reviews studies on the anticonvulsant activities of essential oils and their chemical constituents. Data from studies published from January 2011 to December 2018 was selected from the PubMed database for examination. The bioactivity of 19 essential oils and 16 constituents is described. Apiaceae and Lamiaceae were the most promising botanical families due to the largest number of reports about plant species from these families that produce anticonvulsant essential oils. Among the evaluated compounds, β-caryophyllene, borneol, eugenol and nerolidol were the constituents that presented antioxidant properties related to anticonvulsant action. These data show the potential of these natural products as health promoting agents and use against various types of seizure disorders. Their properties on oxidative stress may contribute to the control of this neurological condition. However, further studies on the toxicological profile and mechanism of action of essential oils are needed.

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Effects of gamma-decanolactone on seizures induced by PTZ-kindling in mice

Cited by 30 publications

References 22 publications

Medicinal compounds with antiepileptic/anticonvulsant activities

Medicinal compounds with antiepileptic/anticonvulsant activities

Anticonvulsant and antioxidant actions of trimetazidine in pentylenetetrazole-induced kindling model in mice

Anticonvulsant Essential Oils and Their Relationship with Oxidative Stress in Epilepsy

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