Effects of high-intensity interval training on optic nerve head and macular perfusion using optical coherence tomography angiography in healthy adults

Schmitz, Boris; Nelis, Pieter; Rolfes, Florian; Alnawaiseh, Maged; Klose, Andreas; Krüger, Michael; Eter, Nicole; Brand, Stefan-Martin; Alten, Florian

doi:10.1016/j.atherosclerosis.2018.04.028

Cited by 36 publications

(30 citation statements)

References 38 publications

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“…Our large normative database allowed us to analyze four FAZ metrics (area, axis ratio, acircularity, and MHAA) that have been used in various OCTA studies. 7 , 9 , 27 – 29 , 33 – 46 We evaluated whether there was interocular symmetry for each of the four metrics and assessed how different sources of variation contribute to the overall variance of each metric. These analyses are important for clinicians and imaging researchers to consider when deciding on the appropriate metric to be used as an imaging biomarker in a clinical setting or in research trials utilizing OCTA.…”

Section: Discussionmentioning

confidence: 99%

Variability of Foveal Avascular Zone Metrics Derived From Optical Coherence Tomography Angiography Images

Linderman

Muthiah

Omoba

et al. 2018

Trans. Vis. Sci. Tech.

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PurposeTo characterize sources of inter- and intrasubject variability in quantitative foveal avascular zone (FAZ) metrics.MethodsTwo 3×3-mm optical coherence tomography angiography scans (centered on the fovea) were acquired in both eyes of 175 subjects. An image of the superficial plexus was extracted from each scan and segmented twice by a single observer. Four quantitative FAZ morphology metrics (area, axis ratio, acircularity, major horizontal axis angle) were calculated, and a variance components analysis was performed.ResultsMean (±SD) age was 27.9 ± 11.9 years, and 55% were female. Area had the largest amount of variance resulting from intersubject differences (93.1%). In contrast, there was large interocular variance for axis ratio, acircularity, and major horizontal axis angle (55.0%, 53.7%, 70.7%, respectively), though only axis ratio showed significant asymmetry between fellow eyes (P < 0.05). Neither repeated images from the same eye nor repeated segmentation on the same image were significant sources of variance.ConclusionsMetrics of FAZ morphology show excellent repeatability and reliability. Excluding FAZ area, there was a high amount of variance attributed to interocular differences for the other FAZ metrics; therefore, the fellow eye should not be considered a control for FAZ studies when using these metrics.Translational RelevanceVision scientists must be prudent when choosing FAZ metrics, as they display varying degrees of within-subject differences relative to between-subject differences. It seems likely that different metrics will be best suited for different tasks, such as monitoring small changes over time within a single subject or assessing whether a given FAZ is abnormal.

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Section: Discussionmentioning

confidence: 99%

Variability of Foveal Avascular Zone Metrics Derived From Optical Coherence Tomography Angiography Images

Linderman

Muthiah

Omoba

et al. 2018

Trans. Vis. Sci. Tech.

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“…Creating a suitable, but shorter, exercise program with the characteristics of continuous endurance training is being considered by sports science experts. One of the training methods suggested by the experts of this field is high intensity interval training (HIIT), which is a powerful method for improving endurance performance with an advantage over traditional continuous endurance training in terms of saving time (25)(26)(27). Investigations have shown that doing these exercises for several weeks improves factors involved in metabolism such as maximum aerobic capacity, maximum activity of mitochondrial enzymes and mitochondrial biogenesis (28).…”

Section: Introductionmentioning

confidence: 99%

The Effects of Six Weeks High Intensity Interval Training on Amyloid Beta1-42 Peptide in Hippocampus of Rat Model of Alzheimer's Disease Induced with STZ

Naderi

Habibi

Kesmati

et al. 2018

J Clin Res Paramed Sci

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Background: Alzheimer's disease is the formaton of amyloid beta (Aβ) plaques and tau tangles in the brain. As Aβ is an important factor in the pathogenesis of Alzheimer's disease, the present research aims to consider the effects of six weeks of high intensity interval training on Aβ1-42 levels in the hippocampus tissue of male rat models of Alzheimer's disease.Methods: Thirty-five rats (3 months old, 222.83 ± 19.60 g) were divided into five groups: Two experimental, two control and sham.Alzheimer's disease, induced by streptozotocin was infused into the rats i.c.v (a 3 m.g/kg dose). Their memory was evaluated by passive avoidance learning method using a shuttle box. The amount of peptide Aβ1-42 was measured by the ELISA method. Comprisions between groups were performed by One-way ANOVA followed by Tukey test. A value of P < 0.05 was considered to be significant. Results:The Aβ1-42 levels in the hippocampus of Alzheimer's control group was significantly higher than Alzheimer's HIIT group (P = 0.036) and it was lower in the health HIIT group than it was in the health control group (P = 0.001). Conclusions:It declare that HIIT training lessen the level of Aβ1-42 in the hippocampus and can be benefit for AD rat model. As a result, the advantages of HIIT training can be used in protection and treatment of AD.

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“…Sixty-five young healthy moderately trained female and male students (all Caucasian, mean age 21.52 ± 2.20 years, 43 females) of the University’s Physical Education Department were recruited at the Institute of Sports Medicine of the University Hospital Muenster in May 2017 as reported elsewhere. [11] All participating students had self-assigned to a recurrent seminar of the department in a ‘first-come first-served’ process without further selection.…”

Section: Methodsmentioning

confidence: 99%

“…Recently, our group contributed data on long-term changes in ocular perfusion measured by OCTA in response to a controlled physical training intervention. [11] Thus, we hypothesized that regular physical activity and physical fitness might affect OCTA measures in healthy adults.…”

Section: Introductionmentioning

confidence: 99%

Correlation analysis of physical fitness and retinal microvasculature by OCT angiography in healthy adults

Nelis¹,

Schmitz²,

Klose³

et al. 2019

PLoS ONE

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Optical coherence tomography angiography (OCT-A) represents the most recent modality in retinal imaging for non-invasive and depth-selective visualization of blood flow in retinal vessels. With regard to quantitative OCTA measurements for early detection of subclinical alterations, it is of great interest, which intra- and extra-ocular factors affect the results of OCTA measurements. Here, we performed OCTA imaging of the central retina in 65 eyes of 65 young healthy female and male participants and evaluated individual physical fitness levels by standard lactate diagnostic using an incremental maximal performance running test. The main finding was that OCTA measurements of the foveal avascular zone (FAZ) area were associated with physical fitness. Using multivariate regression analysis, we found that running speed at the individual lactate threshold, a marker strongly associated with aerobic performance capacity, significantly contributed to differences in FAZ area (β = 0.111, p = 0.032). The data indicates that smaller FAZ areas are likely observed in individuals with higher aerobic exercise capacity. Our findings are also of interest with respect to the potential use of retinal OCTA imaging to detect exercise-induced microvascular adaptations in future studies.

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Effects of high-intensity interval training on optic nerve head and macular perfusion using optical coherence tomography angiography in healthy adults

Cited by 36 publications

References 38 publications

Variability of Foveal Avascular Zone Metrics Derived From Optical Coherence Tomography Angiography Images

Variability of Foveal Avascular Zone Metrics Derived From Optical Coherence Tomography Angiography Images

The Effects of Six Weeks High Intensity Interval Training on Amyloid Beta1-42 Peptide in Hippocampus of Rat Model of Alzheimer's Disease Induced with STZ

Correlation analysis of physical fitness and retinal microvasculature by OCT angiography in healthy adults

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