Effects ofRosa rugosaPetals on Intestinal Bacteria

Abstract

The effects of pulverized petal of Rosa rugosa on the growth of 10 species of intestinal and pathogenic bacteria were investigated. Growth of bifidobacteria and lactobacilli was not affected by the addition of the petal in plate cultivation. However, the growth of Bacteroides vulgatus, Escherichia coli, Staphylococcus aureus, and Bacillus cereus was completely inhibited by the addition of 0.1, 0.5, 0.1, and 0.05% (w/v) of the petal respectively. In liquid cultivation, the addition of the petal (0.5%) stimulated the growth of Bifidobacterium breve and slightly inhibited the growth of Lactobacillus salivarius. But the growth of E. coli, S. aureus, B. cereus, and Salmonella sp. was inhibited by nearly 50%. Hydrolyzable tannins isolated from R. rugosa, rugosin D, and tellimagradin II showed antibacterial activities against E. coli, S. aureus, B. cereus, and Salmonella sp., but little or no effect against Bif. breve and L. salivarius. R. rugosa petal showed selective antibacterial activities against intestinal and pathogenic bacteria, and the selectivity resembled that of prebiotics such as oligosaccharides and dietary fiber. Hydrolyzable tannins in R. rugosa, such as rugosin D and tellimagradin II, must be active constituents.

Biological activity and composition of teas and tinctures prepared from Rosa rugosa Thunb.

“…However, this astringent property is also responsible for their antidiarrheal action which may be valued in some circumstances. Moreover, significant antioxidant, antibacterial, antimutagenic effects of tannins are known [12]. The tannin content in teas was determinated using the modified pharmacopoeial method [16].…”

“…gallic acid, ellagic acid), o-dihydroxyphenols (e.g. caffeic acid) and hydrolysable tannins in various R. rugosa parts [1,8,12,32]. These compounds possess proven cytotoxic, antimicrobial and antioxidant activity [8,12,30].…”

“…Similarly, there are only a few data on antibacterial and antitumor properties of the plant. Petals have been shown to have selective antibacterial activity against intestinal and pathogenic bacteria [12]. In terms of antitumor activity, Lee et al [13] demonstrated that methanolic extracts from rose stem acted as anti-prostate cancer agents.…”

Growth stimulation/inhibition effect of medicinal plants on human intestinal microbiota

“…Very limited studies reported certain growth stimulation of medicinal plants and bioactive compounds on intestinal microbiota. Haedanghwa (Rosa rugosa) petals promoted the growth of B. breve, but the growth of pathogenic bacteria was inhibited by nearly 50% (30). Accordingly, 1,4-and 1,8-dihydroxyanthraquinones from sickle pod exhibited strong growth-promoting activity on B. bifidum, but inhibited the growth of C. perfringens (31).…”

Inhibitory effect of tannins from galls of Carpinus tschonoskii on the degranulation of RBL-2H3 Cells

“…Previous studies have reported apoptotic effect on HL-60 cells, antiinflammatory activity of casuarinin (9) (Yang et al 2000;Pan et al 2000), anti-dementia activity of tellimagradin II (6) and pentagallolylglucose (3) extracted from Sanguisorbae Radix (Lee et al 2005), anti-diabetic activity of pentagallolylglucose (3) extracted from Paeonia lactiflora roots (Baumgartner et al 2010), anti-oxidation activity of casuarinin (9) extracted from Terminalia arjuna (Chen et al 2004) and T. chebula (Cheng et al 2003), anti-oxidation and antitumor activities of pentagallolylglucose (3) (Okuda et al 2009), antibacterial activity of tellimagradin II (6) extracted from Rosa rugosa (Kamijo et al 2008), antioxidant activity and DPPH radical-scavenging activity of pedunculagin (5), casuarictin (4) and casuarinin (9) isolated from walnuts (Juglans regia L.), and preventive effect on liver damage induced by carbon tetrachloride of tellimagrandin II (6) and casuarictin (4) isolated from walnuts (J. regia L.) (Fukuda et al 2003;Shimoda et al 2008). Inhibitory effects of apple condensed tannins on compound 48/80-induced mast cell degranulation (Tokura et al 2005) and on histamine release from RBL cells (Kanda et al 1998) were reported.…”