Effects of Kaurenoic Acid and Arginine on Random Skin Flap Oxidative Stress, Inflammation, and Cytokines in Rats

Silva, Joaquim José de Lima; Pompeu, Débora Gramosa; Ximenes, Naiara Coelho; Duarte, Antoniella Souza Gomes; Gramosa, Nilce V.; Carvalho, Krishnamurti de Morais; Brito, Gerly Anne de Castro; Guimarães, Sérgio Botelho

doi:10.1007/s00266-015-0559-8

Cited by 28 publications

(11 citation statements)

References 27 publications

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“…The oral administration of copaiba has been used as another form of alternative therapy with controversial results. With 28.6%, in the present meta-analysis, the oral administration of copaiba has been shown to be an effective agent against certain parasites, 14 gastrointestinal cancer, 8 6,7,15 arthritis, 16 and other conditions. Contrary to what was thought, the oral administration of copaiba was shown to be non-toxic to rat liver when used as a carrier for amphotericin B.…”

Section: Resultsmentioning

confidence: 72%

“…These differences in toxicity reported in the use of copaiba oil were even more evident when Teixeira et al 1 demonstrated that 200 mg/kg/day presented low toxicity and positive results in inflammatory processes. Similarly, Silva et al 6,7 demonstrated that 50 μg/mL of nanocomposite system (Nano COR) was developed and a toxicity test was performed. The tests showed that Nano COR has a greater impact on the behavior of human endometriotic stromal cells than on the behavior of eutopic endometrium stromal cells, supporting the idea that Nano COR, a form of copaiba oil, should be further investigated as a novel and valuable alternative to treat endometriosis.…”

Section: Resultsmentioning

confidence: 99%

“…3 Another component from copaiba oil with potent antioxidant and anti-inflammatory properties is kaurenoic acid. 6,7 According to Silva et al 16 , the results of their research demonstrated a significant decrease in tumor necrosis factor α (TNF-α) and Interleukin-1 (IL-1) expression and myeloperoxidase (MPO) activity at the T1/T2 time point.…”

Section: Resultsmentioning

confidence: 99%

“…4 Other, newer studies are being performed to find other forms of administration. 6,7 In vitro experiments have shown direct damage to the DNA of cancerous stomach cells with the administration of copaiba oil. The responsible agent in copaiba oil was found to be kaurenoic acid.…”

Section: Introductionmentioning

confidence: 99%

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Meta-analysis on Copaiba Oil: Its Functions in Metabolism and Its Properties as an Anti-inflammatory Agent

et al. 2018

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Recent studies demonstrated that one of the major components of the copaiba oil, β-caryophyllene, has an anti-inflammatory effect. 4 Copaiba oil is extracted from the copaifera, a Abstract Many medicinal plants are sought as alternative therapies for various conditions, as opposed to synthetic alternatives. The Brazilian Amazon provides a plethora of plants with various therapeutic and medicinal properties. One of them is copaiba oil, a natural product of the biodiversity of the Amazon. The anti-inflammatory and antimicrobial properties of copaiba oil have been drawing the attention of the scientific community as a great alternative in the treatment of illnesses associated with inflammatory and infectious processes. The purpose of the present study is to evaluate and analyze the latest publications on the use of copaiba oil in the PubMed/Medline database from 2014 to 2017. Forty-two articles were collected, verifying anti-inflammatory activity, antimicrobial activity, healing, and antitumor activity. The results found on researches with copaiba oil according to publication dates were 11.9% in 2014, 38.1% in 2015, 16.7% in 2016, and 33.3% in 2017. In the analyzed studies, the proposed administration of copaiba oil was 50% topical, 28.6% oral, 9.5% enteral, 4.8% subcutaneous, and 7.1% others. In the objectives of the presente study in relation to the administration of copaiba oil, the result was 31% antimicrobial, 28.6% anti-inflammatory, 9.5% antitumor, 9.5% healing, and 21% others. Regarding the types of research, we have found 50% in vitro, 40.4% in vivo animals, 2.4% in vivo human, 2.4% review and 4.8% others. Regarding the significance factor evaluation, the result was 100% positive in antitumor activity, 84% positive in infection and inflammation pathology, 62% positive in others, like dental processes, food technology application support and as a drug absorption vehicle, and 50% in healing. The results presented in the current meta-analysis show that copaiba oil is an effective alternative to treatments of illnesses such as chronic inflammation, infectious diseases, various types of cancer, autoimmune diseases, and as a vehicle for the absorption of other drugs. Thus, more studies regarding the benefits of copaiba oil could provide a great contribution to the medical community in the treatment of the aforementioned illnesses.

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Section: Resultsmentioning

confidence: 72%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Meta-analysis on Copaiba Oil: Its Functions in Metabolism and Its Properties as an Anti-inflammatory Agent

et al. 2018

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“…It was found that cell inflammatory factors played an important role in ischemia-reperfusion injury, which can lead to tissue morphological damage and dysfunction (10,11). Therefore, anti-inflammatory response is a major research focus aiming to alleviate ischemia-reperfusion injury and improve flap survival rate (12).…”

Section: Discussionmentioning

confidence: 99%

Effects of SB202190 on expression levels of IL-6 and NF-κB in flap ischemia-reperfusion injury

Guo

Liang

2018

Exp Ther Med

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The aim of the current study was to investigate the effect of SB202190, a specific inhibitor of p38 MAPK signaling pathway, on the expression levels of IL-6 and NF-κB in flap ischemia-reperfusion injury. Healthy Sprague-Dawley rats were randomly divided into four groups of 12 each. For the ischemia-reperfusion group, the flap was constructed and then sutured after 8 h of ischemia. For the saline group, rats were intraperitoneally infused with saline at regular intervals after flap ischemia-reperfusion. For the inhibitor group, rats were intraperitoneally infused with SB202190 at regular intervals after flap ischemia-reperfusion. For the control group, the flap was constructed and then sutured immediately. The flap survival rate of each group was measured after 7 days. The concentration of IL-6 in serum was measured by ELISA kit. The mRNA and protein expression levels of IL-6 and NF-κB in the flap were measured using RT-PCR and western blot analysis, respectively. In the ischemia-reperfusion group and the saline group, the flap survival rates were much lower than that in the control group (P<0.05). By contrast, the mRNA and protein expression levels of IL-6 and NF-κB in the flap and the concentration of IL-6 in serum were much higher (P<0.05). In the inhibitor group, the flap survival rate was significantly higher than those in the ischemia-reperfusion and saline groups (P<0.05). By contrast, the concentration of IL-6 in serum and the mRNA and protein expression levels of NF-κB and IL-6 in the flap were significantly decreased (P<0.05). The results show that, SB202190 played a role in the protection of the flap by reducing the inflammatory response in flap ischemia-reperfusion injury.

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Kauranes as Anti-inflammatory and Immunomodulatory Agents: An Overview of In Vitro and In Vivo Effects

Mijares

Martínez

Sanctis

2022

Plant Secondary Metabolites

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Effects of Kaurenoic Acid and Arginine on Random Skin Flap Oxidative Stress, Inflammation, and Cytokines in Rats

Cited by 28 publications

References 27 publications

Meta-analysis on Copaiba Oil: Its Functions in Metabolism and Its Properties as an Anti-inflammatory Agent

Meta-analysis on Copaiba Oil: Its Functions in Metabolism and Its Properties as an Anti-inflammatory Agent

Effects of SB202190 on expression levels of IL-6 and NF-κB in flap ischemia-reperfusion injury

Kauranes as Anti-inflammatory and Immunomodulatory Agents: An Overview of In Vitro and In Vivo Effects

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