Effects of lead and/or cadmium on the distribution patterns of some essential trace elements in immature female rats

Wang, Lin; Zhou, Xue-Lei; Yang, Du-Bao; Wang, Zhenyong

doi:10.1177/0960327111405865

Cited by 20 publications

(9 citation statements)

References 30 publications

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“…This effect of Mg could be explained by competitive antagonism between Cd and Mg at the level of GIT, as well as by corrective effect of Mg on Cd-induced extensive elimination of Zn via urine. Extensive loss of Zn via urine as a consequence of Cd exposure was previously confirmed not only in experimental conditions [25, 26], but also in workers exposed to Cd [27]. Moreover, a positive correlation between Cd and Zn in urine was found in individuals exposed to low levels of Cd in the environment [28].…”

Section: Discussionmentioning

confidence: 73%

Effect of Magnesium Supplementation on the Distribution Patterns of Zinc, Copper, and Magnesium in Rabbits Exposed to Prolonged Cadmium Intoxication

Bulat

Đukić-Ćosić

Antonijević

et al. 2012

The Scientific World Journal

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The present study is designed to investigate whether magnesium (Mg) supplementation may prevent Cd-induced alterations in zinc (Zn), copper (Cu), and magnesium (Mg) status in rabbits. For this purpose, the concentrations of Zn, Cu, and Mg were estimated in blood, urine, and organs (brain, heart, lungs, liver, kidney, spleen, pancreas, skeletal muscle, and bone) of rabbits given Cd (10 mg/kg b.w.) and rabbits cotreated with Mg (40 mg/kg b.w.) orally, as aqueous solutions of Cd chloride and Mg acetate every day for 4 weeks. Samples were mineralized with conc. HNO3 and HClO4 (4:1) and metals concentrations were determined by atomic absorption spectrophotometry (AAS). Magnesium supplementation succeeded to overcome Cd-induced disbalance of investigated bioelements. Beneficial effects of Mg were observed on Zn levels in blood and urine, on Cu levels in urine, and on Mg levels in blood. Magnesium pretreatment also managed to counteract or reduce all Cd-induced changes in levels of Cu and Mg in organs, while it did not exert this effect on Zn levels. These findings suggest that enhanced dietary Mg intake during Cd exposure can have at least partly beneficial effect on Cd-induced alterations in homeostasis of zinc, copper, and magnesium.

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Section: Discussionmentioning

confidence: 73%

Effect of Magnesium Supplementation on the Distribution Patterns of Zinc, Copper, and Magnesium in Rabbits Exposed to Prolonged Cadmium Intoxication

Bulat

Đukić-Ćosić

Antonijević

et al. 2012

The Scientific World Journal

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“…Additionally, trace elements such as Cu and Zn can interact with the metabolism of Cd. Wang and colleges showed that exposure to Cd had resulted in a significant increase in the urinary excretion of Cu and Zn especially in kidney and serum (Wang et al, 2011). This study suggested that increasing urinary loss of antioxidant trace elements due to Cd exposure had induced the deficiency of antioxidants in the body, which could result in further oxidative damage.…”

Section: Discussionmentioning

confidence: 99%

Influence of chronic cadmium exposure on the tissue distribution of copper and zinc and oxidative stress parameters in rats

et al. 2015

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The aim of this study was to investigate the effect of oral cadmium (Cd) intoxication on the antioxidant response and its relationship with essential bioelements like copper (Cu) and zinc (Zn). The experimental group was chronically exposed to Cd daily for 8 weeks via consumption of water containing 15 ppm cadmium chloride. Cu, Zn, and Cd concentrations and oxidative stress parameters were analyzed in liver, kidney, and heart tissues. Exposure to Cd led to a significant decrease in the activities of superoxide dismutase in all considered samples while a significant increase in the activity of glutathione peroxidase except for the kidney. We found a significant increase in malondialdehyde concentration in the tissues except for heart. Also oral administration of Cd caused a significant reduction of Zn and Cu in the tissues. Our results allow us to hypothesize that higher Cd concentration in the tissues causes oxidative stress by increasing malondialdehyde as a means of altering antioxidant defense system and deterioration of bioelements in rat liver, kidney, and heart. In addition, further studies are needed to explain the effect of long-term, low-dose exposure to Cd on distribution of bioelements and its relationship with oxidative stress.

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“…Further oxidative damage to the rats exposed to high levels of Cd in drinking water could occur as a result of the increased urinary excretion of Se, Cu, Mn, and Zn, i.e. the elements involved in anti-oxidative processes (Wang et al 2011). More rarely, a potential synergistic effect of Se and other essential elements was assessed to enhance their protective effect against the Cdinduced oxidative stress.…”

Section: Resultsmentioning

confidence: 99%

Effect of selenium-enriched defatted rape seeds on tissue cadmium and essential elements utilization in rats

Myška¹,

Száková²,

Fučíková³

et al. 2016

CZECH J ANIM SCI

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ABSTRACT:The effect of selenium-enriched defatted rapeseeds (DRS) added to the diet on Se uptake by rat organisms (whole blood, liver, kidney) was investigated in model conditions. Additionally, the response of other essential trace and major mineral elements (Cu, Ca, Fe, K, Mg, Mn, P, S, and Zn) in rat organisms on selenium and/or DRS addition was assessed. The experimental diets for the individual experimental groups were prepared as follows: group DRS 0 (control diet), group DRS 30 (30% of soybean meal in the diet replaced with DRS), group DRS60 (60% of soybean meal in the diet replaced with DRS), and group DRS100 (100% of soybean meal in the diet replaced with DRS), either unenriched or naturally fortified with Se. Whereas Se content in the blood and liver of the animals remained unchanged, increased Se levels were observed in kidney of the selenized DRS100 group compared to the others. Moreover, the results showed decreasing Cd content in the rat liver with increasing Se content in the diet, confirming antagonism of these elements. Concerning the essential elements, the application of the selenized DRS did not result in any serious imbalance in the utilization of these elements. In contrast, Se addition seems to be helpful for the improved utilization of essential elements such as P, S, and Zn, compared to the DRS-containing diet without Se fortification.

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Effects of lead and/or cadmium on the distribution patterns of some essential trace elements in immature female rats

Cited by 20 publications

References 30 publications

Effect of Magnesium Supplementation on the Distribution Patterns of Zinc, Copper, and Magnesium in Rabbits Exposed to Prolonged Cadmium Intoxication

Effect of Magnesium Supplementation on the Distribution Patterns of Zinc, Copper, and Magnesium in Rabbits Exposed to Prolonged Cadmium Intoxication

Influence of chronic cadmium exposure on the tissue distribution of copper and zinc and oxidative stress parameters in rats

Effect of selenium-enriched defatted rape seeds on tissue cadmium and essential elements utilization in rats

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