Effects of Minerals Added to Medicinal Plant Extracts on Alcohol-Induced Oxidative Stress and Alcohol Metabolism in Rats

이석준,; 김안드레,; 이재화,; 김미희,; 이봉상,; 지영택,; 빈재훈,; 하종명,

doi:10.3746/jkfn.2011.40.3.393

Cited by 7 publications

(1 citation statement)

References 15 publications

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“…The ADH activation rate of fermented persimmon and GABA standard increased by 34.07% and 20.41% compared to persimmon. ADH, one of the key enzymes for the metabolism of alcohol in the human body, reduces its activity in the case of long-term heavy drinking or excessive drinking which causes alcohol damage to the stomach and liver and other organs (Lee et al, 2011). The results of this experiment showed that fermented persimmon juice and GABA could increase the activity of ADH and promote the metabolism of ethanol.…”

Section: Anti-hangover Activitymentioning

confidence: 74%

Anti-hangover and anti-hypertensive effects in vitro of fermented persimmon juice

Zhou

Mao

et al. 2019

CyTA - Journal of Food

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This study aimed to develop and characterize a fermented persimmon juice with potential antihangover and anti-hypertensive effects using gamma-aminobutyric acid (GABA)-producing lactic acid bacteria. Results showed the co-fermentation of Lactobacillus plantarum C17 and Lactobacillus pentosus Lp-B produced the highest yield of 2.102 mmol/L of GABA. After 48 h of fermentation, GABA was produced at the conversion rate of 69.32% from glutamate. The alcohol dehydrogenase activation rate, acetaldehyde dehydrogenase activation activity and hydroxyl inhibition rate of fermented persimmon juice were 38.91%, 34.72%, and 16.79%, respectively, which displayed higher anti-hangover activity compared to unfermented persimmon. Moreover, the angiotensin-converting enzyme inhibition ability of fermented persimmon juice was 42.34% and the expression level of human endothelin-1 was reduced to 34.64 μg/mL. These findings indicated GABA-enriched fermented persimmon juice had potential anti-hangover and anti-hypertensive properties.Efectos antiresaca y antihipertensivos del jugo de caqui fermentado in vitro RESUMEN El presente estudio tuvo como objetivo desarrollar y caracterizar un jugo de caqui fermentado con posibles efectos antiresaca y antihipertensivos utilizando bacterias ácido lácticas productoras de ácido gamma-aminobutírico (GABA). Los resultados revelan que la fermentación conjunta de Lactobacillus plantarum C17 y Lactobacillus pentosus Lp-B produce un rendimiento más alto de GABA, de 2.102 mmol/ L. Transcurridas 48 horas de fermentación se produjo GABA a partir de glutamato a una tasa de conversión del 69.32%. La tasa de activación de alcohol deshidrogenasa, la tasa de activación de acetaldehído deshidrogenasa y la tasa de inhibición de hidroxilo del jugo de caqui fermentado registraron niveles de 38.91%, 34.72% y 16.79%, respectivamente. Estos resultados dan cuenta de una mayor efecto antiresaca en comparación con el jugo de caqui no fermentado. Además, se constató que la capacidad de inhibición de la enzima convertidora de angiotensina del jugo de caqui fermentado fue de 42.34% y que el nivel de expresión de endotelina-1 humana se redujo a 34.64 μg/ml. Estos hallazgos indican que el jugo de caqui fermentado enriquecido con GABA tiene propiedades que potencialmente permiten reducir la resaca y la hipertensión.

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Section: Anti-hangover Activitymentioning

confidence: 74%

Anti-hangover and anti-hypertensive effects in vitro of fermented persimmon juice

Zhou

Mao

et al. 2019

CyTA - Journal of Food

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Effect of Mixture Including Hot Water Extract of Houttuynia cordata Thunb on Ethanol-Induced Hangover in Rats

유양희¹,

이현미²,

정창식³

et al. 2016

Journal of the Korean Society of Food Science and Nutrition

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Anti-Fatigue Effect of Cornus officinalis Sieb. et Zucc. Extract in Forced Swimming Test

Lee

Shin

Noh

et al. 2021

JKFN

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This study examined the effects of Corni Fructus administration on the exercise performance and fatigue accumulation in the forced swimming test (FST). The ICR mice were divided randomly into four groups: water-treated FST (control), 500 mg/kg of red ginseng-treated FST (RG), 500 mg/kg of water extract of Corni Fructus-treated FST (CFW), and 500 mg/kg of 30% EtOH extract of Corni Fructus-treated FST (CFE). After FST, an autopsy was performed, and the soleus muscle and serum were collected. The experimental result show that the running time increased in the CFW. In addition, the soleus muscle showed that glycogen was increased by CFW and CFE. Furthermore, CFW significantly regulated GOT (glutamic oxaloacetic transaminase), GPT (glutamic pyruvic transaminase), BUN (blood urea nitrogen), ammonia, LDH (lactate dehydrogenase), D-lactate, TG (triglyceride), and FFA (free fatty acid) in serum. On the other hand, CFE regulated the above factors but not significantly. Overall, CFW and CFE in FST are considered effective in preventing fatigue by controlling the liver enzyme, kidney enzyme, and fatigue-related factors, and the CFW is considered to be more effective than CFE.

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Effects of Minerals Added to Medicinal Plant Extracts on Alcohol-Induced Oxidative Stress and Alcohol Metabolism in Rats

Cited by 7 publications

References 15 publications

Anti-hangover and anti-hypertensive effects in vitro of fermented persimmon juice

Anti-hangover and anti-hypertensive effects in vitro of fermented persimmon juice

Effect of Mixture Including Hot Water Extract of Houttuynia cordata Thunb on Ethanol-Induced Hangover in Rats

Anti-Fatigue Effect of Cornus officinalis Sieb. et Zucc. Extract in Forced Swimming Test

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