Effects of orally administered vanadium on the immune system and bone metabolism in experimental animals

Mravcová, A.; Jírová, Dagmar; Jančí, H.; Lener, Jaroslav

doi:10.1016/s0048-9697(05)80069-5

Cited by 25 publications

(18 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Vanadium also is a potent inhibitor of several phosphohydrolases, such as Na + K + -ATPase [8] and Ca 2+ -ATPase [9], an activator of adenyl cyclase [10] and a potent anticarcinogenic agent [11]. Some studies have been reported to reveal vanadium toxicity, including oxidative stress [12] and immunotoxicity [13] in rats and rabbits.…”

Section: Introductionmentioning

confidence: 99%

Excess Dietary Vanadium Induces the Changes of Subsets and Proliferation of Splenic T Cells in Broilers

Cui

Peng

et al. 2010

Biol Trace Elem Res

View full text Add to dashboard Cite

The purpose of this 42-day study was to investigate the effects of dietary excess vanadium on immune function by determining changes of the subsets and proliferation function of splenic T cells. Four hundred twenty 1-day-old avian broilers were divided into six groups and fed on a corn-soybean basal diet as control diet or the same diet amended to contain 5, 15, 30, 45, and 60 ppm of vanadium supplied as ammonium metavanadate. When compared with those of the control group, the percentage of CD3+, CD3+CD4+, and CD3+CD8+ of splenic T cells were decreased in the 45 and 60 ppm groups; however, the percentage of CD3+ and CD3+CD4+ were increased in the 5 ppm group, and the CD4+/CD8+ ratios were raised in the 5 and 15 ppm groups at 14 days of age. Meanwhile, the proliferation of splenic T cells were depressed in the 45 and 60 ppm groups but raised in the 5 and 15 ppm groups. Also, the serum interleukin-2 (IL-2) and interleukin-6 (IL-6) contents were decreased in the 45 and 60 ppm groups and increased in the 5 ppm group. It was concluded that dietary vanadium in excess of 30 ppm changed the percentages of splenic T cell subsets and inhibited the proliferation of splenic T cells and reduced the serum IL-2 and IL-6 contents. The cellular immune function was finally impaired in broilers.

show abstract

Section: Introductionmentioning

confidence: 99%

Excess Dietary Vanadium Induces the Changes of Subsets and Proliferation of Splenic T Cells in Broilers

Cui

Peng

et al. 2010

Biol Trace Elem Res

View full text Add to dashboard Cite

show abstract

“…Vanadium pentoxide is eliminated in the urine with a half-life of 15-40hrs. Vanadium pentoxide caused significant increase in number of hypoploids cells (Migliore et al 1993), increase in DNA migration, (Rojas et al 1996), frequency of micronucleus formation in mice (Zhang et al 1993;Rivedal et al, 1990), irritation of eyes, respiratory tract and bronchospasm (Knecht et al 1992), neutrophills influx (Pierce et al 1996), an enlargement of spleen in rats and mice, increased leucocytes count and decreased phagocytes in these animals (Mravcova et.,al 1993),skeletal abnormalities, delayed ossification and decreased fetal body weight and length in developing fetus (Zhang et al 1993). However, there is paucity of information on the qualitative and quantitative effects of vanadium pentoxide especially in the hepatic and reproductive system.…”

mentioning

confidence: 99%

Effects of Vanadium Pentoxide on the Histological and Sperm Parameters of Male Guinea Pigs

Uche¹,

Obianime²,

Gogo-Abite³

2010

Journal of Applied Sciences and Environmental Management

View full text Add to dashboard Cite

ABSTRACT:The pharmacological effects of intraperitoneal administration of different doses of vanadium pentoxide (V 2 O 5 ) on the histological and sperm parameters of male guinea pigs were investigated. Also investigated were the effects of oral pretreatment with different doses of vitamin E (a known protein kinase C inhibitor) on the V 2 O 5 -induced responses of the testis and liver of male guinea pigs. In n = 5 experiments, vanadium pentoxide in the dose range of 4.5-12.5mg/kg caused destruction of the testicular and liver architecture. This was characterized by a reduction in spermatogonia, destruction of seminiferous tubules, necrosis of the testicular tissues, necrosis of liver cells, fatty cells infiltration and vacoulation. Oral administration/ pretreatment with vitamin E in the dose range of 500-2000I.U caused a reversal of the vanadium pentoxide -induced histological damages of the testis and the liver cells. Furthermore, in n = 5 animals experiments, Vanadium pentoxide (4.5-12.5 mg/kg/) caused a statistically significant increase in the percentage basal cell death, from 5.0 to 75.0 ± 1.0%, reduction in sperm motility from 90.0 to 31.0 ± 3.9%, reduction in sperm count from 80.0 x10 6 cells/ml to 25.0± 4.0 x 10 6 cells/ml and alteration in the spermatic cell morphology ( i.e. causing a change in the cellular structure of sperm cells and an increase in abnormal cells count) of the male guinea pigs. These inhibitory effects were significant at P < 0.05 (ANOVA). These effects were all dose-and time-dependent and may have a role in oxidative pathology of vanadium pentoxide. @ JASEM

show abstract

“…The tolerance limits of the foreign ions are given in Table 1. In this reaction system, various oxidants such as CrO 4 2-, Fe 3+ and Ce 4+ interfere. Fe 3+ can be extracted by using methyl isobutyl ketone [21,22].…”

Section: Effect Of Diverse Ionsmentioning

confidence: 99%

“…Recently, vanadium has been noticed as the index element in urban environmental pollution, especially air pollution [3]. Laboratory and epidemiological evidences suggest that vanadium may also play a beneficial role in the prevention of heart disease [4]. Shamberger [5] has pointed out that human heart disease death rates are lower in countries where more vanadium occurs in the environment.…”

Section: Introductionmentioning

confidence: 99%

<b> A SIMPLE SPECTROPHOTOMETRIC DETERMINATION OF TRACE AMOUNTS OF VANADIUM USING THIONIN </b>

Cherian

Narayana

2005

Bull. Chem. Soc. Eth.

View full text Add to dashboard Cite

ABSTRACT.A simple and sensitive spectrophotometric method has been developed for the determination of trace amounts of vanadium using thionin as a chromogenic reagent. The proposed method is based on the reaction of vanadium(V) with potassium iodide in acid medium to liberate iodine, which bleaches the violet colour of thionin and is measured at 600 nm. This decrease in absorbance is directly proportional to the vanadium(V) concentration and obeys Beer's law in the range of 0.2-10 •gmL -1 of V(V). The molar absorptivity, Sandell's sensitivity, detection limit and quantitation limit of the method were found to be 2. , respectively. The optimum reaction conditions and other analytical conditions were evaluated. The effect of interfering ions on the determination is described. The developed method has been successfully applied to the analysis of the vanadium in synthetic and alloy samples.

show abstract

Effects of orally administered vanadium on the immune system and bone metabolism in experimental animals

Cited by 25 publications

References 3 publications

Excess Dietary Vanadium Induces the Changes of Subsets and Proliferation of Splenic T Cells in Broilers

Excess Dietary Vanadium Induces the Changes of Subsets and Proliferation of Splenic T Cells in Broilers

Effects of Vanadium Pentoxide on the Histological and Sperm Parameters of Male Guinea Pigs

<b> A SIMPLE SPECTROPHOTOMETRIC DETERMINATION OF TRACE AMOUNTS OF VANADIUM USING THIONIN </b>

Contact Info

Product

Resources

About