Effects of phosphatidylserine in age‐associated memory impairment

Crook, Thomas H.; Tinklenberg, Jared R.; Yesavage, Jerome; Petrie, William M.; Nunzi, Maria Grazia; Massari, D.

doi:10.1212/wnl.41.5.644

Cited by 198 publications

(98 citation statements)

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“…Milk fat globule membrane (MFGM) phospholipids have been shown to have a number of health benefits [4,5,8,9,15], and MFGM material may be successfully used to stabilize emulsions [3,20,21,32] and produce liposomes [29].…”

Section: Introductionmentioning

confidence: 99%

Comparison of hydrophobic and hydrophilic encapsulation using liposomes prepared from milk fat globule-derived phospholipids and soya phospholipids

Thompson

Couchoud

Singh

2009

Dairy Sci. Technol.

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-Liposomes prepared from a milk fat globule membrane (MFGM) phospholipid fraction have been shown to have significantly different physical and chemical characteristics and appeared to be more stable in a variety of conditions than liposomes prepared from soya phospholipid material. These liposome systems were used to try to encapsulate model hydrophobic (β-carotene) and hydrophilic (potassium chromate) compounds. Liposomes produced from the MFGM-derived phospholipids showed significantly higher entrapment efficiencies for both β-carotene and potassium chromate. The differences were particularly apparent when using the hydrophobic molecules at low ratios of β-carotene to phospholipid. It is likely that the improved incorporation efficiency for β-carotene is due to the partitioning of the molecule between the aqueous phase and the phospholipid membrane, a property which will be dependent on the specific composition of the phospholipid material used. The higher encapsulation efficiency for the potassium chromate appeared to reflect the slightly larger diameter of the liposomes produced from the MFGM material. These results suggest that there may be inherent advantages in the use of liposomes prepared from MFGM-derived phospholipids via microfluidization for the encapsulation of both hydrophobic and hydrophilic compounds.

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Section: Introductionmentioning

confidence: 99%

Comparison of hydrophobic and hydrophilic encapsulation using liposomes prepared from milk fat globule-derived phospholipids and soya phospholipids

Thompson

Couchoud

Singh

2009

Dairy Sci. Technol.

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“…Clinical investigations have also shown that B-PS treatment can improve Alzheimer's disease (AD) and related cognitive disorders (8,9). Sakai et al (10) prepared soybean leci thin transphosphatidylated phosphatidylserine (SB-tPS) from soybean phosphatidylcholine by transphosphati dylation using phospholipase D, and they found that the intravenous or intraperitoneal administration of SB-tPS increases brain glucose concentrations in mice and antagonizes amnesic effects of scopolamine (SCP) in rats, as did B-PS.…”

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confidence: 99%

Effects of Oral Administration of Soybean Lecithin Transphosphatidylated Phosphatidylserine on Impaired Learning of Passive Avoidance in Mice

Furushiro

Shishido

Sakai

et al. 1997

Japanese Journal of Pharmacology

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ABSTRACT-Soybean lecithin transphosphatidylated phosphatidylserine (SB-tPS) was investigated for its effect on the impaired learning of a passive avoidance task by mice induced by scopolamine or cyclohex imide. SB-tPS (240, 360, 480 mg/kg) administered orally significantly prolonged the step-through latency shortened by scopolamine. SB-tPS (240 mg/kg) administered orally also prolonged the step-through latency shortened by cycloheximide. These results suggest that the effect of SB-tPS on the impaired learning behavior may be related not only to the cholinergic system but also the serotonergic system.

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“…Research on the substances has produced mixed findings. In one study, 149 patients who met the criteria for age-associated memory impairment were treated for 12 weeks with a formulation of phosphatidylserine or placebo (Crook et al, 1991). Patients in the treatment group improved on performance tests related to learning and memory and tasks of daily life.…”

Section: Phosphadtidylserine and Phosphatidylcholinementioning

confidence: 99%

Utility of Nutraceutical Products Marketed for Cognitive and Memory Enhancement

McDougall

Austin-Wells²,

Zimmerman

2005

J Holist Nurs

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This article identifies a convenience sample of 14 memory-enhancing herbal products that were found to be available commercially, examines their active ingredients, states their claims, and evaluates the available evidence to determine their efficacy. The analyses identified four problematic areas. First, a majority of the products use cognitive terminology, which leads consumers to anticipate an intended cognitive benefit. Second, some ingredients are completely homeopathic and contain components not known outside of the homeopathic field. Third, the evidence of treatment efficacy is often contradictory, because products are recommended for purposes other than cognitive or memory loss. Finally, the manufacturers of the product have usually conducted the research on individual products. Until more research is available, it is suggested that holistic nursing professionals exercise caution in recommending nutraceuticals to their patients/clients for the use of cognitive improvement or memory enhancement.

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Effects of phosphatidylserine in age‐associated memory impairment

Cited by 198 publications

References 0 publications

Comparison of hydrophobic and hydrophilic encapsulation using liposomes prepared from milk fat globule-derived phospholipids and soya phospholipids

Comparison of hydrophobic and hydrophilic encapsulation using liposomes prepared from milk fat globule-derived phospholipids and soya phospholipids

Effects of Oral Administration of Soybean Lecithin Transphosphatidylated Phosphatidylserine on Impaired Learning of Passive Avoidance in Mice

Utility of Nutraceutical Products Marketed for Cognitive and Memory Enhancement

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