Effects of prebiotics, probiotics, and synbiotics on the infant gut microbiota and other health outcomes: A systematic review

Ferro, Lynn; Crowley, Liana N; Bittinger, Kyle; Friedman, Elliot S.; Decker, Jessica; Russel, K. Brooke; Katz, Sarah; Kim, Jae Kyeom; Trabulsi, Jillian

doi:10.1080/10408398.2021.2022595

Cited by 15 publications

(5 citation statements)

References 54 publications

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“…We are not aware of further studies on infant stool consistency and microbiota in the general population, only in functional gastrointestinal orders 51 and as intervention outcomes. 52 , 53 However, Bristol score is a common measure of stool consistency in adults with a well-established link to gut microbiota composition, 54 and has been identified to explain 5% of the total microbiota variation in adult gut microbiota, 55 indicating that the association between gut microbiota and stool consistency is important as suggested also by our previous study. 9 Future work should also carefully assess bidirectionality as it is possible that stool composition is a consequence, not a cause, of microbiota composition.…”

Section: Discussionmentioning

confidence: 58%

Sources of gut microbiota variation in a large longitudinal Finnish infant cohort

et al. 2023

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Section: Discussionmentioning

confidence: 58%

Sources of gut microbiota variation in a large longitudinal Finnish infant cohort

et al. 2023

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“…Relevant studies have also indicated that gut microbiota modulates immune and inflammatory system responses, and is proven to be very effective in preventing and treating diseases such as constipation, intestinal infections, asthma, and allergies ( 17 , 26 , 27 ). Compared to prebiotics and probiotics alone, synbiotics may be a more effective approach to regulating the gut, promoting the growth and diversity of probiotics, and supporting the immune system development of infants ( 16 , 17 , 28 , 29 ). A cross-sectional study in Palestine found that parents have a certain degree of misunderstanding and improper use of antibiotics; whereby abuse and early discontinuation of antibiotics may have a negative impact on their children’s health ( 16 , 30 ).…”

Section: Discussionmentioning

confidence: 99%

Knowledge, attitude, and practice of Chinese parents with infants (aged 0–3 years) toward immunity, gut microbiota and biotics: a comprehensive study

Wang,

Liu,

Chen

et al. 2024

Front. Immunol.

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In the wake of the COVID-19 pandemic, there has been an increasing focus towards infant immunity. The development and maintenance of the immune system are significantly influenced from birth, and is shaped by early-life infant feeding behavior. Hence, the knowledge, attitude, and practice (KAP) of parents play a crucial role in shaping the immune system of infants. A total of 2369 parents across 19 cities in China were surveyed using a self-designed online questionnaire. The KAP questionnaire assessed three domains: immunity, gut microbiota, and biotics (prebiotics, probiotics, and synbiotics). The questionnaire also included questions on infant health. An overwhelming majority of parents (97.90%) placed high value on their children’s immunity, and 40.40% of them reported an increased level of concern following the COVID-19 pandemic. Diarrhea (78.80%), colds (75.70%), nighttime crying (73.80%), regurgitation (71.70%) and food retention (66.50%) were the major health issues reported. Knowledge scores toward immunity and gut microbiota were positively correlated to attitude and practice scores, respectively. Attitude scores toward immunity, gut microbiota and biotics were positively correlated to their respective practice scores. Parental knowledge score on immunity was negatively correlated with diarrhea, colds, regurgitation and food retention. On the other hand, parental practice scores toward immunity were negatively correlated with food retention. In regards to gut microbiota, parental knowledge score was negatively correlated with diarrhea, regurgitation and food retention; parental attitude score was negatively correlated with nighttime crying whereas practice score was negatively correlated with diarrhea, regurgitation, food retention and nighttime crying. Attitude score toward biotics was negatively correlated with nighttime crying and practice scores toward biotics was negatively correlated with colds, food retention and nighttime crying. This study demonstrated that significant gaps and misunderstandings exist among parents regarding immunity, gut microbiota health, and biotics. Both public education and interventions are crucial to enhance parental knowledge and practices, thereby improving infant immunity.

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“…The balance between these processes is crucial for maintaining bone homeostasis. Recent studies have identified specific bacteria associated with positive or negative effects on bone health, such as Lactobacillus and Bifidobacterium genera, while dysbiosis, an imbalance in the GM composition, has been associated with conditions like inflammatory bowel disease [ 13 ▪▪ , 14 – 16 ]. Understanding the role of specific bacteria in bone metabolism offers potential targets for therapeutic interventions.…”

Section: Gastrointestinal Microorganism and Bone Metabolismmentioning

confidence: 99%

The interaction between gut microbiome and bone health

Inchingolo,

Piras

et al. 2024

Current Opinion in Endocrinology, Diabetes &Amp; Obesity

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Purpose of review This review critically examines interconnected health domains like gut microbiome, bone health, interleukins, chronic periodontitis, and coronavirus disease 2019 (COVID-19), offering insights into fundamental mechanisms and clinical implications, contributing significantly to healthcare and biomedical research. Recent findings This review explores the relationship between gut microbiome and bone health, a growing area of study. It provides insights into skeletal integrity and potential therapeutic avenues. The review also examines interleukins, chronic periodontitis, and COVID-19, highlighting the complexity of viral susceptibility and immune responses. It highlights the importance of understanding genetic predispositions and immune dynamics in the context of disease outcomes. The review emphasizes experimental evidence and therapeutic strategies, aligning with evidence-based medicine and personalized interventions. This approach offers actionable insights for healthcare practitioners and researchers, paving the way for targeted therapeutic approaches and improved patient outcomes. Summary The implications of these findings for clinical practice and research underscore the importance of a multidisciplinary approach to healthcare that considers the complex interactions between genetics, immune responses, oral health, and systemic diseases. By leveraging advances in biomedical research, clinicians can optimize patient care and improve health outcomes across diverse patient populations.

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Effects of prebiotics, probiotics, and synbiotics on the infant gut microbiota and other health outcomes: A systematic review

Cited by 15 publications

References 54 publications

Sources of gut microbiota variation in a large longitudinal Finnish infant cohort

Sources of gut microbiota variation in a large longitudinal Finnish infant cohort

Knowledge, attitude, and practice of Chinese parents with infants (aged 0–3 years) toward immunity, gut microbiota and biotics: a comprehensive study

The interaction between gut microbiome and bone health

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