Effects of rambutan (Nephelium lappaceum) peel phenolics and Leu-Ser-Gly-Tyr-Gly-Pro on hairless mice skin photoaging induced by ultraviolet irradiation

Xiao, Junjiang; Liu, Bingtong; Zhuang, Yongliang

doi:10.1016/j.fct.2019.04.020

Cited by 26 publications

(21 citation statements)

References 36 publications

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“…Xiao et al. (2019) revealed that rambutan peel phenolics and LSGYGP exerted an additive effect on the amelioration of the biochemical indices of UV‐induced photoaging skin. Takashi et al.…”

Section: Introductionmentioning

confidence: 99%

Protective effect againstd‐gal‐induced aging mice and components of polypeptides and polyphenols in defatted walnut kernel during simulated gastrointestinal digestion

Tian

Sun

et al. 2021

Journal of Food Science

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Defatted walnut kernel with pellicle (WKP) is an industrial byproduct during walnut oil extraction, which is rich in protein and polyphenols. WKP was hydrolyzed by simulated gastrointestinal digestion to obtain WKP hydrolysates (WKPHs). Results showed the protein recovery and hydrolysis degree of WKPH were 82.15 and 10.36%. The total phenol contents in WKP and WKPH were 4.90 and 40.70 mg gallic acid equivalent/g, respectively. The antiaging activity of WKPH was evaluated using a d‐gal‐induced aging mouse model. Results showed that WKPHs could recover the activities of SOD and T‐AOC and the content of MDA in tissues and serum of the aging mice. The histological morphology of liver and kidney sections and the immunohistochemistry of TNF‐α, IL‐1β, and IL‐6 in liver were observed. WKPH could effectively protect the tissue structure of the liver and kidney and reduce the inflammatory expression of liver in aging mice. The polypeptides and polyphenols in WKPH were further analyzed. Fifty polypeptides were identified and 12 of these peptides had Leu‐Arg at the C‐terminal. Forty‐two polyphenols were detected, and most phenolic compounds belonged to ellagitannins. This study provided a theoretical basis for the improved processing and high‐value utilization of walnut byproducts. Practical Application Defatted walnut kernel with pellicle was hydrolyzed by simulated gastrointestinal digestion to obtain its hydrolysates. The hydrolysates have good antiaging activity in vivo. Fifty polypeptides were identified and 12 of these peptides had Leu‐Arg at the C‐terminal. Forty‐two polyphenols were detected, and most phenolic compounds belonged to ellagitannins. This study could provide a theoretical basis for high‐value utilization of walnut byproducts.

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Section: Introductionmentioning

confidence: 99%

Protective effect againstd‐gal‐induced aging mice and components of polypeptides and polyphenols in defatted walnut kernel during simulated gastrointestinal digestion

Tian

Sun

et al. 2021

Journal of Food Science

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“…Thus, it is continually damaged by environmental factors such as chemicals, fine dust particles, and ultraviolet (UV) irradiation [1]. These environmental factors cause various effects on the skin including oxidative stress, inflammatory responses, melanin accumulation, and collagen degradation, leading to skin aging [2][3][4][5]. The appearance of the skin directly contributes to personal beauty [6].…”

Section: Introductionmentioning

confidence: 99%

The Potential of Sulfated Polysaccharides Isolated from the Brown Seaweed Ecklonia maxima in Cosmetics: Antioxidant, Anti-melanogenesis, and Photoprotective Activities

et al. 2020

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Sulfated polysaccharides prepared from marine algae are potential ingredients in nutraceutical, pharmaceutical, and cosmeceutical industries. In the present study, the antioxidant, anti-melanogenesis, and photoprotective effects of sulfated polysaccharides obtained from Ecklonia maxima (EMC) were investigated to evaluate their potential in cosmetic. EMC was successfully prepared through Celluclast-assisted extraction and ethanol precipitation, and it contained 79.88% of sulfated polysaccharides that with 69.37% carbohydrates and 10.51% sulfate. EMC effectively suppressed 2,2-azobis(2-amidinopropane) hydrochloride (AAPH)-induced oxidative stress in vitro in Vero cells and in vivo in zebrafish. Furthermore, EMC significantly inhibited mushroom tyrosinase and reduced melanin synthesis in alpha-melanocyte-stimulating hormone-stimulated B16F10 cells. In addition, EMC remarkably attenuated photodamage induced by UVB irradiation in vitro in human keratinocytes (HaCaT cells) and in vivo in zebrafish. Furthermore, EMC effectively inhibited wrinkle-related enzymes and improved collagen synthesis in UVB-irradiated human dermal fibroblasts (HDF cells). These results indicate that EMC possesses strong antioxidant, anti-melanogenesis, and photoprotective activities, and suggest that EMC may be an ideal ingredient in the pharmaceutical and cosmeceutical industries.

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“…We first evaluated the recovery effects of MED on the phenotypes and histological structure of skin in UV-irradiated nude mice. The nude mice were decided on the basis of results from previous research for anti-photoaging activity of biomaterials and natural products because this mouse can evaluate both skin protection and anti-inflammation effects of these substances at the same time [ 25 , 26 , 27 , 28 ]. The wrinkle scores, which included consideration of wrinkle depths and numbers, were remarkably enhanced in the UV + Vehicle-treated group, but these enhancements were significantly decreased in the UV + MED-treated groups ( Figure 7 a).…”

Section: Resultsmentioning

confidence: 99%

Therapeutic Effects of Dipterocarpus tuberculatus with High Antioxidative Activity Against UV-Induced Photoaging of NHDF Cells and Nude Mice

et al. 2021

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To investigate the therapeutic effects of methanol extracts of Dipterocarpus tuberculatus Roxb. (MED) against UV-induced photoaging, we assessed for alterations in the antioxidant activity, anti-apoptotic effects, ECM modulation, skin appearances, and anti-inflammatory response in normal human dermal fibroblast (NHDF) cells and nude mice orally treated with MED. High levels of tannin content and high free radical scavenging activity to DPPH were determined in MED, while seven active components, namely, gallic acid, bergenin, ellagic acid, ε-viniferin, asiatic acid, oleanolic acid, and 2α-hydroxyursolic acid, were identified using LC–MS analyses. UV-induced alterations in the NO concentration, SOD activity, and Nrf2 expression were remarkably recovered in MED-treated NHDF cells. Moreover, the decreased number of apoptotic cells and G2/M phase arrest were observed in the UV + MED-treated groups. Similar recoveries were detected for β-galactosidase, MMP-2/9 expression, and intracellular elastase activity. Furthermore, MED treatment induced suppression of the COX-2-induced iNOS mediated pathway, expression of inflammatory cytokines, and inflammasome activation in UV-radiated NHDF cells. The anti-photoaging effects observed in NHDF cells were subsequently evaluated and validated in UV + MED-treated nude mice through skin phenotypes and histopathological structure analyses. Taken together, these results indicate that MED exerts therapeutic effects against UV-induced photoaging and has the potential for future development as a treatment for photoaging.

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Effects of rambutan (Nephelium lappaceum) peel phenolics and Leu-Ser-Gly-Tyr-Gly-Pro on hairless mice skin photoaging induced by ultraviolet irradiation

Cited by 26 publications

References 36 publications

Protective effect againstd‐gal‐induced aging mice and components of polypeptides and polyphenols in defatted walnut kernel during simulated gastrointestinal digestion

Protective effect againstd‐gal‐induced aging mice and components of polypeptides and polyphenols in defatted walnut kernel during simulated gastrointestinal digestion

The Potential of Sulfated Polysaccharides Isolated from the Brown Seaweed Ecklonia maxima in Cosmetics: Antioxidant, Anti-melanogenesis, and Photoprotective Activities

Therapeutic Effects of Dipterocarpus tuberculatus with High Antioxidative Activity Against UV-Induced Photoaging of NHDF Cells and Nude Mice

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