Effects of serotonin depletion on punishment processing in the orbitofrontal and anterior cingulate cortices of healthy women

Helmbold, K.; Zvyagintsev, Mikhail; Dahmen, Brigitte; Bubenzer-Busch, S.; Gaber, Tilman J.; Crockett, Molly J.; Klasen, Martin; Sánchez, Cristina; Eisert, Albrecht; Konrad, Kerstin; Habel, Ute; Herpertz‐Dahlmann, Beate; Zepf, Florian Daniel

doi:10.1016/j.euroneuro.2015.02.007

Cited by 27 publications

(20 citation statements)

References 45 publications

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“…Using the outlined depletion paradigms, it is not possible to elucidate specific dopaminergic or serotonergic functions related to different brain regions and isolated neurocircuits. Depletion may vary from one brain region to another region ( 58 , 59 ). Studies that combine functional neuroimaging techniques and depletion and other neurochemical concepts are of particular value to examine the impact of different neurotransmitters in healthy and vulnerable populations regarding different brain regions ( 58 , 59 ).…”

Section: Discussionmentioning

confidence: 99%

Effects of dietary tryptophan and phenylalanine–tyrosine depletion on phasic alertness in healthy adults – A pilot study

Hildebrand¹,

Königschulte²,

Gaber³

et al. 2015

Food & Nutrition Research

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BackgroundThe synthesis of the neurotransmitters serotonin (5-HT) and dopamine (DA) in the brain can be directly altered by dietary manipulation of their relevant precursor amino acids (AA). There is evidence that altered serotonergic and dopaminergic neurotransmission are both associated with impaired attentional control. Specifically, phasic alertness is one specific aspect of attention that has been linked to changes in 5-HT and DA availability in different neurocircuitries related to attentional processes. The present study investigated the impact of short-term reductions in central nervous system 5-HT and DA synthesis, which was achieved by dietary depletion of the relevant precursor AA, on phasic alertness in healthy adult volunteers; body weight–adapted dietary tryptophan and phenylalanine–tyrosine depletion (PTD) techniques were used.MethodsThe study employed a double-blind between-subject design. Fifty healthy male and female subjects were allocated to three groups in a randomized and counterbalanced manner and received three different dietary challenge conditions: acute tryptophan depletion (ATD, for the depletion of 5-HT; N=16), PTD (for the depletion of DA; N=17), and a balanced AA load (BAL; N=17), which served as a control condition. Three hours after challenge intake (ATD/PTD/BAL), phasic alertness was assessed using a standardized test battery for attentional performance (TAP). Blood samples for AA level analyses were obtained at baseline and 360 min after the challenge intake.ResultsOverall, there were no significant differences in phasic alertness for the different challenge conditions. Regarding PTD administration, a positive correlation between the reaction times and the DA-related depletion magnitude was detected via the lower plasma tyrosine levels and the slow reaction times of the first run of the task. In contrast, higher tryptophan concentrations were associated with slower reaction times in the fourth run of the task in the same challenge group.ConclusionThe present study is the first to demonstrate preliminary data that support an association between decreased central nervous system DA synthesis, which was achieved by dietary depletion strategies, and slower reaction times in specific runs of a task designed to assess phasic alertness in healthy adult volunteers; these findings are consistent with previous evidence that links phasic alertness with dopaminergic neurotransmission. A lack of significant differences between the three groups could be due to compensatory mechanisms and the limited sample size, as well as the dietary challenge procedures administered to healthy participants and the strict exclusion criteria used. The potential underlying neurochemical processes related to phasic alertness should be the subject of further investigations.

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Section: Discussionmentioning

confidence: 99%

Effects of dietary tryptophan and phenylalanine–tyrosine depletion on phasic alertness in healthy adults – A pilot study

Hildebrand¹,

Königschulte²,

Gaber³

et al. 2015

Food & Nutrition Research

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“…Dietary acute tryptophan depletion (ATD) is one well‐established method of studying serotonergic function and can easily be combined with neuroimaging . In this study, we investigated the effects of a short‐term reduction in central nervous 5‐HT synthesis by means of ATD, on DMN functional connectivity (FC) with brain areas known to be associated with core symptoms of ADHD.…”

Section: Introductionmentioning

confidence: 99%

Resting state default mode network connectivity in children and adolescents with ADHD after acute tryptophan depletion

Biskup

Helmbold

Baurmann

et al. 2016

Acta Psychiatr Scand

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“…The DMN and the PCC are involved in emotion processing, regulation, and introspection [Klasen et al, ; Maddock et al, ; Otto et al, ; Singer, ; Teasdale, ]. Similar to the insula, the PCC is involved in processing and control of salient negative emotional stimuli [Vogt, ], and increased activation is associated to situations with immediately harmful outcome for specific opponents [Helmbold et al, ; White et al, ]. On the molecular level, local and autoinhibitory 5‐HT1A binding inversely modulated the posterior cingulate cortex [Hahn et al, ], which may render this region particularly sensitive to changes in 5‐HT availability.…”

Section: Discussionmentioning

confidence: 99%

“…Such negative affect bias is a specific feature of Borderline and impulsive aggressive personality disorders in which serotonergic neurotransmission is disturbed [Lee et al, ; Leyton et al, ]. Moreover, activation of brain areas related to aggression and impulsivity (i.e., such as the orbitofrontal cortex) were correlated with ATD‐related depletion magnitude and trait‐impulsivity [Helmbold et al, ]. In summary, genetic and pharmacological alterations of 5‐HT levels affect neural correlates of emotion regulation and impulse control.…”

Section: Introductionmentioning

confidence: 99%

Cortico‐limbic connectivity in MAOA‐L carriers is vulnerable to acute tryptophan depletion

Eisner

Klasen

Wolf

et al. 2016

Human Brain Mapping

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Effects of serotonin depletion on punishment processing in the orbitofrontal and anterior cingulate cortices of healthy women

Cited by 27 publications

References 45 publications

Effects of dietary tryptophan and phenylalanine–tyrosine depletion on phasic alertness in healthy adults – A pilot study

Effects of dietary tryptophan and phenylalanine–tyrosine depletion on phasic alertness in healthy adults – A pilot study

Resting state default mode network connectivity in children and adolescents with ADHD after acute tryptophan depletion

Cortico‐limbic connectivity in MAOA‐L carriers is vulnerable to acute tryptophan depletion

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