Effects of silver nanoparticle-based antimicrobial formulations on the properties of denture polymer: A systematic review and meta-analysis of in vitro studies

Bangera, Madhu Keshava; Kotian, Ravindra; Madhyastha, Prashanthi S

doi:10.1016/j.prosdent.2021.05.011

Cited by 14 publications

(11 citation statements)

References 75 publications

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“…The variations in the SH are said to be due to the dispersion of the NPs other factors such as use of silane coupling agent, mixing methods used for dispersion for minimum agglomerates formation and the greater presence of cross-linking in the surface layers than the internal layers of the material. 45,[73][74][75] With regards to the SR, the conclusive effect of increasing the percentage could not be obtained, however, at 3% the SR was found to increase. Factors such as the dispersion of the NP to close the gap in the resin matrix, presence of the amount of nanoparticle on the surface and hydrophobicity of the nano-resin composite play important roles to determine the SR. [76][77][78] The clinical significance of this property cannot be underestimated as with the increase in the SR larger number of sites are available for microbial adhesion, however only two studies evaluated the microbial adhesion on addition of different concentrations of TiO 2 NP.…”

Section: Methods For Testing Propertiesmentioning

confidence: 81%

Effect of addition of titanium dioxide nanoparticles on the antimicrobial properties, surface roughness and surface hardness of polymethyl methacrylate: A Systematic Review.

et al. 2023

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Background: Polymethyl Methacrylate (PMMA) denture-base resins have poor surface properties that facilitates microbial adhesion causing denture stomatitis. This systematic review aims to evaluate the effect of different sizes and percentages of titanium dioxide nanoparticles (TiO2NP) on the antimicrobial property, surface roughness and surface hardness of PMMA denture base resin. Methods: A systematic search of English peer-reviewed articles, clinical trial registries, grey literature databases and other online sources was performed using the PRISMA-S Guidelines for In-Vivo and In-Vitro studies. Qualitative data synthesis was performed to analyse sample dimensions, acrylic used, treatments of nanoparticles, methods used for testing and effect of size and percentage of nanoparticle. Risk of bias assessment was done using modified Cochrane risk of bias tool. Results: Out of 1376 articles, 15 were included. TiO2NP of size less than 30 nm was most frequently used. Both antimicrobial property and surface hardness improved irrespective of the size of the added TiO2NP. Three studies reported increase in the surface roughness with less than 50 nm TiO2NP. 3% TiO2NP was most frequently used. On increasing the percentage, three studies reported an increase in antimicrobial property, while two studies found no change. With TiO2NP greater than or equal to 3%, six studies reported an increase in surface hardness, while two reported increase in surface roughness. Large methodological variations were observed across studies. All studies except one were of moderate quality. Conclusions: On addition of TiO2NP to heat polymerized PMMA, the antimicrobial property and surface hardness improved irrespective of the size of the TiO2NP, however, addition of nanoparticles less than 50 nm increased the surface roughness. Increasing the percentage of TiO2NP increased the surface hardness but did not always increase the antimicrobial property. Addition of 3% TiO2NP provided optimum results with regards to antimicrobial effect and surface hardness, but increase in the surface roughness.

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Section: Methods For Testing Propertiesmentioning

confidence: 81%

Effect of addition of titanium dioxide nanoparticles on the antimicrobial properties, surface roughness and surface hardness of polymethyl methacrylate: A Systematic Review.

et al. 2023

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“…The smaller particle size and large surface area of AgNPs provide potent antibacterial effects at a low filler level, diminishing the AgNPs concentration necessary for its efficacy and avoiding negative influence on mechanical properties. Also, they penetrate through cell membranes more readily, resulting in higher antimicrobial activity, which is especially important since microorganisms in biofilms are more resistant to antimicrobial agents [45].…”

Section: Biological Propertiesmentioning

confidence: 99%

A review on acceptability of denture polymers having gold and silver nanoparticles

Eswaran¹,

A²,

Noureen³

et al. 2022

IJDM

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In dentistry, polymethyl methacrylate (PMMA) is commonly used as a base material for dentures. PMMA has been widely used in a range of dental applications because of its specific features, including its low density, aesthetics, cost-effectiveness, ease of manipulation, and flexible physical and mechanical characteristics. Despite having many advantageous qualities, it has a lot of cons like weak flexural strength, poor wear resistance, polymerization shrinkage, and poor durability etc., The emergence of nanotechnology has allowed for the improvement of the afore-mentioned drawbacks through the use of different nanoparticles. Silver nanoparticles have been used in dentistry due to their antimicrobial, and antifungal properties. They also enhance the mechanical properties of materials leading to improved outcomes. Gold nanoparticles are available in different sizes and concentrations to exhibit their beneficial outcomes. This review aimed to discuss the properties of silver and gold nanoparticles, their form of incorporation, benefits, acceptance and their clinical significance when added with denture polymers.

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“…Surface hardness is a consequence of structural variations in the PMMA and the uniformity of the nanofiller dispersion. 14 The indentation depth greatly influences hardness values. However, an improved surface hardness may be because of a local increase in reinforcing fillers.…”

Section: Surface Hardnessmentioning

confidence: 99%

Behavior of nanosilver and nanotitanium reinforced polymethyl methacrylate for dental applications

et al. 2021

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The study evaluated the mechanical, tribological, and cytocompatibility properties of silver nanoparticles and titanium dioxide nanoparticles reinforced into polymethyl methacrylate resin. Both nanoparticles were separately ball-milled with polymethyl methacrylate, and a conventional compression molding technique prepared samples in a thermostatically controlled water bath. Samples were analyzed for flexural strength, polishability, three-body abrasive wear, surface hardness, and cytotoxicity. The fracture mechanics and surface roughness were further analyzed using a field emission scanning electron microscope. Most properties showed improvement at the said concentration compared to the control group, while few did not show property enhancement.The cell proliferation and viability were not compromised. Within study limits, silver nanoparticles and titanium dioxide nanoparticles reinforced polymethyl methacrylate resin positively influenced the dental polymer to a certain extent.The nanocomposite is cytocompatible at the tested concentrations. Prereaction of the polymer, treating nanoparticles with coupling agents, determining an optimal additive size and concentration, and use of effective dispersion technique may further enhance the properties of the nanocomposites.

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Effects of silver nanoparticle-based antimicrobial formulations on the properties of denture polymer: A systematic review and meta-analysis of in vitro studies

Cited by 14 publications

References 75 publications

Effect of addition of titanium dioxide nanoparticles on the antimicrobial properties, surface roughness and surface hardness of polymethyl methacrylate: A Systematic Review.

Effect of addition of titanium dioxide nanoparticles on the antimicrobial properties, surface roughness and surface hardness of polymethyl methacrylate: A Systematic Review.

A review on acceptability of denture polymers having gold and silver nanoparticles

Behavior of nanosilver and nanotitanium reinforced polymethyl methacrylate for dental applications

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