Effects of social isolation rearing on the limbic brain: A combined behavioral and magnetic resonance imaging volumetry study in rats

Schubert, Mirjam; Porkess, M. V.; Dashdorj, Naranjargal; Fone, Kevin C. F.; Auer, Dorothee P.

doi:10.1016/j.neuroscience.2008.12.019

Cited by 92 publications

(70 citation statements)

References 88 publications

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“…Rats were fostered at birth, eight rats were housed singly, and eight were housed in groups of five (other littermates also included) on postnatal day 28. The efficacy of the model was confirmed as the isolated animals showed a significant reduction (p Ͻ 0.01) in prepulse inhibition of acoustic startle compared with their group-housed littermates as reported previously (18). Isolated and grouped animals were housed in the same holding room for 12 weeks (44).…”

Section: Methodssupporting

confidence: 59%

Identification of Targeted Analyte Clusters for Studies of Schizophrenia

Cheng

Guest

et al. 2010

Molecular & Cellular Proteomics

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The search for biomarkers to diagnose psychiatric disorders such as schizophrenia has been underway for decades. Many molecular profiling studies in this field have focused on identifying individual marker signals that show significant differences in expression between patients and the normal population. However, signals for multiple analyte combinations that exhibit patterned behaviors have been less exploited. Here, we present a novel approach for identifying biomarkers of schizophrenia using expression of serum analytes from first onset, drug-naïve patients and normal controls. The strength of patterned signals was amplified by analyzing data in reproducing kernel spaces. This resulted in the identification of small sets of analytes referred to as targeted clusters that have discriminative power specifically for schizophrenia in both human and rat models. These clusters were associated with specific molecular signaling pathways and less strongly related to other neuropsychiatric disorders such as major depressive disorder and bipolar disorder. These results shed new light concerning how complex neuropsychiatric diseases behave at the pathway level and demonstrate the power of this approach in identification of disease-specific biomarkers and potential novel therapeutic strategies. Molecular & Cellular Proteomics 9: 510 -522, 2010.

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Section: Methodssupporting

confidence: 59%

Identification of Targeted Analyte Clusters for Studies of Schizophrenia

Cheng

Guest

et al. 2010

Molecular & Cellular Proteomics

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“…For instance, neonatal stress affected dendritic organization and synaptic plasticity in the PFC in rats [99][100][101] . Post-weaning social isolation specifically reduced the volume of posterodorsal component of the medial amygdala and of the right medial PFC in rats 102,103 . However, neural plasticity markers, neuron numbers and basal metabolic activities were not altered in the limbic brain after early social subjugation in rats and hamsters [104][105][106] , suggesting that structural changes are minimal following this stressor.…”

Section: Structural Changesmentioning

confidence: 92%

Stress and the social brain: behavioural effects and neurobiological mechanisms

2015

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“…However, this was not seen in female rats. Schubert et al 39 applied magnetic resonance volumetry to the limbic system of isolated rats and observed no volume reduction in the hippocampi, but a 5% reduction in the volume of the mPFC, a region that is strongly directly and indirectly (through ACC) connected to the VS.…”

Section: Abnormal Neurodevelopmentmentioning

confidence: 99%

Biological Mechanisms Whereby Social Exclusion May Contribute to the Etiology of Psychosis: A Narrative Review

Selten

Booij

Buwalda

et al. 2017

SCHBUL

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The purpose of this review is to examine whether a contribution of social exclusion to the pathogenesis of psychosis is compatible with the dopamine hypothesis and/or the neurodevelopmental hypothesis. Humans experience social exclusion as defeating. An animal model for defeat is the resident-intruder paradigm. The defeated animal shows evidence of an increased sensitivity to amphetamine, increased dopamine release in the nucleus accumbens and prefrontal cortex, and increased firing of dopaminergic neurons in the ventral tegmental area. As for humans, one study showed that amphetamine-induced striatal dopamine release was significantly greater among nonpsychotic young adults with severe hearing impairment than among normal hearing controls. Two other studies reported an association between childhood trauma and increased dopamine function in striatal subregions. Several studies have suggested that the perigenual anterior cingulate cortex (pgACC) may play a role in the processing of social stress. Importantly, the pgACC regulates the activity of the ventral striatum through bidirectional interconnections. We are not aware of studies in humans that examined whether (proxies for) social exclusion contributes to the structural brain changes present at psychosis onset. Animal studies, however, reported that long-term isolation may lead to reductions in volume of the total brain, hippocampus, or medial prefrontal cortex. Other animal studies reported that social defeat can reduce neurogenesis. In conclusion, the answer to the question as to whether there are plausible mechanisms whereby social exclusion can contribute to the pathogenesis of psychosis is cautiously affirmative.

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Effects of social isolation rearing on the limbic brain: A combined behavioral and magnetic resonance imaging volumetry study in rats

Cited by 92 publications

References 88 publications

Identification of Targeted Analyte Clusters for Studies of Schizophrenia

Identification of Targeted Analyte Clusters for Studies of Schizophrenia

Stress and the social brain: behavioural effects and neurobiological mechanisms

Biological Mechanisms Whereby Social Exclusion May Contribute to the Etiology of Psychosis: A Narrative Review

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