Effects of soy hull polysaccharide on dyslipidemia and pathoglycemia in rats induced by a high-fat-high-sucrose diet

Lin, Qian; Yang, Ling; Lin, Han; Wang, Ziyi; Luo, Mingshuo; Zhu, Danshi; Li, He; Li, Xin; Feng, Yi

doi:10.1016/j.fshw.2021.07.006

Cited by 23 publications

(9 citation statements)

References 43 publications

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“…HIPPEs in the small intestinal digestion stage likely became unstable for the following reasons: (i) proteins on the surface of the oil droplet may have been replaced by other surface active substances in the intestinal fluid, such as amino acids, bile salts, lipases, gut microbiota or free fatty acids (FFAs), resulting in altered composition, structure, and properties of the interfacial layer and thus decreased stability; 44–46 (ii) lipase activity changed the structure and composition of the lipid droplets, thereby reducing their stability. As shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

Enhancing the bioaccessibility of puerarin through the collaboration of high internal phase Pickering emulsions with β-carotene

Yuan

et al. 2022

Food Funct.

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Section: Resultsmentioning

confidence: 99%

Enhancing the bioaccessibility of puerarin through the collaboration of high internal phase Pickering emulsions with β-carotene

Yuan

et al. 2022

Food Funct.

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“…Li et al [ 33 ] reported that the Grifola frondosa polysaccharide (GFP) significantly increased the proportion of Helicobacter, Intestinimonas, Barnesiella, Defluviitalea, Ruminococcus, Flavonifractor, and Paraprevotella in the intestinal flora, but decreased the relative abundance of Clostridium-XVIII, Butyricicoccus, and Turicibacter, thereby inhibiting hypercholesterolemia induced by a high-fat diet. Other studies have reported that soy hull polysaccharide (SHP) restored blood lipid levels in rats fed a high-fat-high sucrose diet by increasing the abundance of Bacteroidetes and decreasing the abundance of Firmicutes and Firmicutes [ 34 ]. It can be seen that polysaccharides play a role in reducing blood lipids by upregulating the abundance of beneficial bacteria and downregulating the abundance of harmful bacteria in the gastrointestinal tract.…”

Section: Hypolipidemic Effect Mechanisms Of Polysaccharidesmentioning

confidence: 99%

An Insight into Antihyperlipidemic Effects of Polysaccharides from Natural Resources

Jing

Pan³

et al. 2022

Molecules

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Hyperlipidemia is a chronic metabolic disease caused by the abnormal metabolism of lipoproteins in the human body. Its main hazard is to accelerate systemic atherosclerosis, which causes cerebrovascular diseases such as coronary heart disease and thrombosis. At the same time, although the current hypolipidemic drugs have a certain therapeutic effect, they have side effects such as liver damage and digestive tract discomfort. Many kinds of polysaccharides from natural resources possess therapeutic effects on hyperlipidemia but still lack a comprehensive understanding. In this paper, the research progress of natural polysaccharides on reducing blood lipids in recent years is reviewed. The pharmacological mechanisms and targets of natural polysaccharides are mainly introduced. The relationship between structure and hypolipidemic activity is also discussed in detail. This review will help to understand the value of polysaccharides in lowering blood lipids and provide guidance for the development and clinical application of new hypolipidemic drugs.

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“…Soybean hulls, which are the seed coat of soybeans (~8%), are one of the major by-products released during the initial cracking process in the production of soybean oil. The vast majority are discarded or used in animal feed ( 6 ). The soybean hull contains variable amounts of cellulose (29-51%), hemicellulose (10-25%), lignin (1-4%), pectins (4-8%) and proteins (11-15%) ( 7 ).…”

Section: Introductionmentioning

confidence: 99%

“…The soybean hull contains variable amounts of cellulose (29-51%), hemicellulose (10-25%), lignin (1-4%), pectins (4-8%) and proteins (11-15%) ( 7 ). Soybean hulls are considered a source of novel polysaccharides, which have been shown to exert hypoglycemic and hypolipidemic effects ( 8 ). However, few reports have explored the functional properties of these polysaccharides, especially in immune regulation.…”

Section: Introductionmentioning

confidence: 99%

“…RAW264.7 murine macrophages are useful to study the molecular mechanisms of macrophages in immune regulation ( 8 ) and the pattern recognition receptors (PRRs) on the surface of immune cells, such as Toll-like receptors (TLRs) that recognize pathogen-related molecular patterns (PAMPs). As a type of PAMP, plant polysaccharides can activate macrophages by specifically binding to their cell membrane receptors and can subsequently activate the mitogen-activated protein kinase (MAPK) and nuclear factor κB (NF-κB) pathways to generate an immune response.…”

Section: Introductionmentioning

confidence: 99%

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Immunostimulatory activity of soybean hull polysaccharide on macrophages

Wang

Zhang

et al. 2022

Exp Ther Med

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Water-soluble polysaccharide isolated from soybean hull and fractionated using ion-exchange chromatography were investigated to determine their molecular characteristics and immunostimulating activity. In the present study, soybean hull polysaccharide (SHP) was separated and purified to obtain three main fractions (F1, F2 and F3), and their chemical and monosaccharide compositions were analyzed. SHP was mainly composed of carbohydrates (64.3%), proteins (16.2%) and sulfates (12.5%), with minor levels of uronic acid (3.2%), and predominantly contained glucose and mannose as monosaccharides. Moreover, when compared with cells treated with RPMI medium, SHP was revealed to promote the proliferation and pinocytosis of RAW264.7 cells, and to enhance the production of nitric oxide (NO), tumor necrosis factor (TNF)-α, interleukin (IL)-1β and IL-6. Furthermore, flow cytometry demonstrated that CD11b and CD40 were involved in the immune regulation of RAW264.7 cells by SHP. Moreover, western blotting and other experiments revealed that SHP, a type of pathogen-associated molecular pattern, was specifically recognized by the Toll-like receptor 2, which, in turn, upregulated the expression levels of proteins downstream of the mitogen-activated protein kinase and nuclear factor κB pathways. Notably, the immune activity of the F2 fraction was markedly higher than that of the crude polysaccharides. In summary, the purified F2 fraction of SHP may be an effective nutritional supplement for human disorders associated with low immunity.

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Effects of soy hull polysaccharide on dyslipidemia and pathoglycemia in rats induced by a high-fat-high-sucrose diet

Cited by 23 publications

References 43 publications

Enhancing the bioaccessibility of puerarin through the collaboration of high internal phase Pickering emulsions with β-carotene

Enhancing the bioaccessibility of puerarin through the collaboration of high internal phase Pickering emulsions with β-carotene

An Insight into Antihyperlipidemic Effects of Polysaccharides from Natural Resources

Immunostimulatory activity of soybean hull polysaccharide on macrophages

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