Effects of Supplemental Boron on Growth Performance and Meat Quality in African Ostrich Chicks

Wang, Wei; Xiao, Ke; Zheng, Xinting; Zhu, Deguang; Yang, Zhi; Tang, Juan; Sun, Pu; Wang, Jing; Peng, Kaiman

doi:10.1021/jf501789t

Cited by 18 publications

(6 citation statements)

References 33 publications

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“…On the other hand, broiler diets containing 60−120 ppm of boron considerably improved feed conversion ratio and growth rate of birds. Unfortunately, dietary boron may be toxic at high doses: 400 mg/kg dietary boron decreased body weight, feed consumption, egg production and egg weight of layers (Wang et al, 2014). Similarly, 160 mg of boron (as boric acid) added to drinking tap water improved growth performance and meat quality of African ostrich chicks.…”

Section: Dietary Boron Action In the Body Bone Growth And Maintenancmentioning

confidence: 99%

“…Similarly, 160 mg of boron (as boric acid) added to drinking tap water improved growth performance and meat quality of African ostrich chicks. On the other hand, higher concentrations of boron in drinking water decreased both: performance and meat quality of chicks (Wang et al, 2014). Past researches show that low-supplemental boric acid (especially 80 mg B per litter of water) could promote intestinal mucosal immunity; these doses of boron in drinking water could promote intestinal cell proliferation and inhibit apoptosis.…”

Section: Dietary Boron Action In the Body Bone Growth And Maintenancmentioning

confidence: 99%

See 1 more Smart Citation

Selected physiological effects of boron compounds for animals and humans. A review

Białek¹,

Czauderna²,

Krajewska³

et al. 2019

J. Anim. Feed Sci.

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Section: Dietary Boron Action In the Body Bone Growth And Maintenancmentioning

confidence: 99%

Section: Dietary Boron Action In the Body Bone Growth And Maintenancmentioning

confidence: 99%

Selected physiological effects of boron compounds for animals and humans. A review

Białek¹,

Czauderna²,

Krajewska³

et al. 2019

J. Anim. Feed Sci.

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“…Boron in nutritional amounts is suggested to be beneficial for the performance of diverse tissues, such as bone, nerve tissue and muscle, and has been used for ostriches [ 10 – 12 ]. Nevertheless, excessive boron (> 400 mg/kg) has been reported to inhibit the development of multiple immune organs (eg, thymus, spleen) in chickens and rats [ 6 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Increased Thymic Cell Turnover under Boron Stress May Bypass TLR3/4 Pathway in African Ostrich

Huang

Xiao

et al. 2015

PLoS ONE

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Previous studies revealed that thymus is a targeted immune organ in malnutrition, and high-boron stress is harmful for immune organs. African ostrich is the living fossil of ancient birds and the food animals in modern life. There is no report about the effect of boron intake on thymus of ostrich. The purpose of present study was to evaluate the effect of excessive boron stress on ostrich thymus and the potential role of TLR3/4 signals in this process. Histological analysis demonstrated that long-term boron stress (640 mg/L for 90 days) did not disrupt ostrich thymic structure during postnatal development. However, the numbers of apoptotic cells showed an increased tendency, and the expression of autophagy and proliferation markers increased significantly in ostrich thymus after boron treatment. Next, we examined the expression of TLR3 and TLR4 with their downstream molecular in thymus under boron stress. Since ostrich genome was not available when we started the research, we first cloned ostrich TLR3 TLR4 cDNA from thymus. Ostrich TLR4 was close to white-throated Tinamou. Whole avian TLR4 codons were under purify selection during evolution, whereas 80 codons were under positive selection. TLR3 and TLR4 were expressed in ostrich thymus and bursa of fabricius as was revealed by quantitative real-time PCR (qRT-PCR). TLR4 expression increased with age but significantly decreased after boron treatment, whereas TLR3 expression showed the similar tendency. Their downstream molecular factors (IRF1, JNK, ERK, p38, IL-6 and IFN) did not change significantly in thymus, except that p100 was significantly increased under boron stress when analyzed by qRT-PCR or western blot. Taken together, these results suggest that ostrich thymus developed resistance against long-term excessive boron stress, possibly by accelerating intrathymic cell death and proliferation, which may bypass the TLR3/4 pathway. In addition, attenuated TLRs activity may explain the reduced inflammatory response to pathogens under boron stress.

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“…The expression of PCNA represents the strength of cell proliferation and reflect the intestinal mucosal cells proliferation and cell hyperplasia. Previous studies documented role of boron in animal growth and development (Eckhert, 1998;Wang et al, 2014) suggesting a possible function for boron in cell growth and proliferation. Park et al (2005) reported that relatively low concentration borate was strongly mitogenic, whereas at high concentrations it was toxic.…”

Section: Discussionmentioning

confidence: 97%

Effects of Supplemental Boron on Intestinal Proliferation and Apoptosis in African Ostrich Chicks

Sun

Luo

et al. 2016

Int. J. Morphol.

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SUMMARY:Boron is an essential trace element which plays an important role in process of metabolism and the function of the tissues. However, the effects of boron on the intestinal cells in African ostrich chicks are poorly reported. Therefore, this study was designed to investigate the role of boron on proliferation and apoptosis of the intestinal cells. A total of 36, ten day-old ostrich chicks were randomly divided into six groups and fed on the same basal diet supplemented with 0, 40, 80, 160, 320 and 640 mg/L boric acid in drinking water for 80 days. Proliferating cell nuclear antigen (PCNA) was used to test the proliferation index of intestine in different group by immunohistochemical staining (IHC). Apoptotic cells of intestine were detected by Dutp-biotin nick end labeling (TUNEL) reaction and evaluated by integral optical density (IOD). Results showed that proliferation of intestinal cells significantly increased in groups of 80, 160, 320 and 640 mg/L. TUNEL reaction showed that apoptosis significantly decreased in 80 mg/L groups, while significantly increased in high dose of boron groups (320 and 640 mg/L), especially in epithelium. In conclusion, low dose of boron-supplemented water could promote cell proliferation and depress apoptosis, while high dose of boron could cause intestinal apoptosis and thus we found increased proliferation of intestine cell as a compensatory adaption. These findings may support optimal dosage of boron that could protect the development of ostrich intestine, while high dosage of boron could suppress it, or even has toxic effects on it.

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Effects of Supplemental Boron on Growth Performance and Meat Quality in African Ostrich Chicks

Cited by 18 publications

References 33 publications

Selected physiological effects of boron compounds for animals and humans. A review

Selected physiological effects of boron compounds for animals and humans. A review

Increased Thymic Cell Turnover under Boron Stress May Bypass TLR3/4 Pathway in African Ostrich

Effects of Supplemental Boron on Intestinal Proliferation and Apoptosis in African Ostrich Chicks

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