Effects of TAM (Taraxacum mongolicum) on Th2 Cytokine Production in MC/9 Mast Cells

Jang, Moonhee; Choi, Jae-Song; Bae, Na-Young; Ahn, Teak-Won

doi:10.7730/jscm.2012.24.1.054

Cited by 3 publications

(2 citation statements)

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“…며느리배꼽 추출물의 주요 성 분으로는 ferulic acid, vanillic acid, quercetin, caffeic acid, protocatechuic acid 등이 있다 (Adachi et al, 2002;Ahn et al, 2009;Yang & Park, 2008) (Chan & Kim, 2011). 그 외에 tyrosinase 저해 활성, B16/F1 melanoma 세포주의 멜라닌 색소 감소효과가 나타났으며 (Kang & Yoo, 2009), 활성화된 mast cell에서 발현하는 cytokine 인 interleukin 4 (IL4), interleukin 5 (IL5), interleukin 6 (IL6), interleukin 13 (IL13)의 생성을 억제함으로써 알레르 기 염증 반응을 효과적으로 조절되었다 (Jang et al, 2012 (Kim et al, 1998;MO et al, 2013 Park & Lee, 2000). 선학초의 성분들은 전초에 agrimonin, agrimonolide, tormentic acid, ellagic acid 등이 있고 잎과 줄기에는 luteolin-7-glucoside이 함유되어 있다 (Pei et al, 1990 (Kim et al, 2006).…”

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Trends in the Efficacy and Safety of Ingredients in Acne Skin Treatments

Lee¹,

Son²

2018

Asian J Beauty Cosmetol

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The aim of this study is to explore trends in safety and efficacy of ingredients used in treatments for acne at a time when the distrust of chemicals is growing. 'Acne' is a chronic inflammatory follicular disorder of the skin. Propionibacterium acnes (P. acnes) plays critical roles in the outbreak of acne by inducing inflammation and forming comedones. Currently, the main methods of treatment for acne vulgaris include oral antibiotics, anti-inflammatory drugs, retinoids, and topical medication. However, prolonged use of these drugs can cause side effects such as skin irritation, dryness, flushing, itching, and resistance to the drug. Thus, there is a demand for effective natural alternatives. Natural extracts that reduce bacterial activity to treat acne are expected to have significantly fewer side effects than existing medications. According to studies anti-bacterial effects are such as Nelumbo nucifera G., Corni fructus , Persicaria perfoliata , Taraxacum mongolicum H., Phragmitis rhizoma , Agrimonia pilosa , Lavandula offcinalis , Cymbopogon martini , Menthapiperita , Eucalyptus globulus, Camellia japonica, ceramide, propolis, epidermal growth factor (EGF) and so on. Further tests of the safety and efficacy of natural extracts with antibacterial properties compared to existing acne medications are needed.

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Trends in the Efficacy and Safety of Ingredients in Acne Skin Treatments

Lee¹,

Son²

2018

Asian J Beauty Cosmetol

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“…Studies on TAM have been continuously conducted to determine its anti-inflammatory efficacy, 15 antiallergenic efficacy, 16 and antioxidant efficacy 17 . However, to date only a few studies have focused on the whitening effect of TAM 18, 19…”

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Inhibitory effects of Taraxacum mongolicum with phreatic water on melanin synthesis

Jang

ahn

2015

Integrative Medicine Research

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BackgroundRecently, people have begun showing heightened interest in skin whitening. Melanin is an important factor that determines skin color. The purpose of this study is to investigate the inhibitory effect of Taraxacum mongolicum (TAM) with phreatic water (PW) from Dogo Hot Springs on melanin synthesis.MethodsWe assessed the inhibitory effects of TAM on melanin synthesis in B16F10 mouse melanoma cells. The mRNA levels of tyrosinase related protein (TRP)-1, TRP-2, tyrosinase, MITF, ERK, and PKA protein were analyzed with reverse transcription polymerase chain reaction and Western blot analysis. We also assessed the inhibitory effects of TAM with PW on melanin synthesis in HRM-2 melanin-possessing hairless mice. After UVB irradiation, differences in melanin were analyzed with an image analysis software between the left dorsal skin (untreated part) and the right dorsal skin (treated part). The mRNA levels of TRP-1, TRP-2, and matrix metalloproteinase (MMP)-9 were analyzed with real-time quantitative polymerase chain reaction. The dorsal skins were analyzed with histological test by hematoxylin and eosin staining.ResultsTAM inhibited the TRP-1, TRP-2, tyrosinase, MITF mRNA gene expression, and PKA protein expression on the concentration-dependent B16F10 cell. Moreover, TAM increased the ERK mRNA gene expression in the B16F10 cell. After UVB irradiation, TAM with PW increased the differences in melanin between the left dorsal skin (untreated part) and the right dorsal skin (treated part) in HRM-2 mice. TAM with PW inhibited the TRP-1, TRP-2, and MMP-9 mRNA gene expression in HRM-2 mice. TAM with PW decreased the epidermal thickness, around the cell deformation, keratinization, and infiltration in HRM-2 mice.ConclusionThese results indicate that TAM with PW has the inhibitory effect of decreasing the melanin synthesis.

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Effect of DOGO phreatic water containing sulphur on Atopic Dermatitis in NC/Nga mouse

Jang¹,

Go²,

Ahn³

et al. 2013

The Journal of Korean Oriental Medical Ophthalmology and Otolar

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Objectives : The purpose of this study is to investigate the effects of DOGO phreatic water containing sulphur on Atopic Dermatitis in NC/Nga mouse. Methods : We made DOGO phreatic water removed sulphur using Twin Alternating Sulfate Eater. After making atopic dermatitis caused by sensitizing NC/Nga mouse to DNCB(dinitrochlorobenzene), we made mouse swim in tanks each filled with distilled water, tap water, DOGO phreatic water(contain sulphur), DOGO phreatic water(remove sulphur) for 30minutes everyday. 3weeks later, we analyzed skin clinical score, total IgE levels(by ELISA), WBC differential counting(Neutrophils, Monocytes), absolute cell number of Neutrophil + Gr-1 + , CCR3 mRNA expressions(by Real-time PCR), IL-4, IFN-Ɣ production levels(by ELISA), histologic test(by H&E staining, toluidine blue staining). Results : The results of making NC/Nga mouse induced atopic dermatitis swim in tanks filled with DOGO phreatic water(contain sulphur) are as follows.

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Effects of TAM (Taraxacum mongolicum) on Th2 Cytokine Production in MC/9 Mast Cells

Cited by 3 publications

References 13 publications

Trends in the Efficacy and Safety of Ingredients in Acne Skin Treatments

Trends in the Efficacy and Safety of Ingredients in Acne Skin Treatments

Inhibitory effects of Taraxacum mongolicum with phreatic water on melanin synthesis

Effect of DOGO phreatic water containing sulphur on Atopic Dermatitis in NC/Nga mouse

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