Effects of titanium dioxide nano-particles on growth and some histological parameters of zebrafish (Danio rerio) after a long-term exposure

Chen, Jin‐Yuan; Dong, Xinghui; Xin, Yuanyuan; Zhao, Meirong

doi:10.1016/j.aquatox.2010.12.004

Cited by 155 publications

(85 citation statements)

References 31 publications

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“…In carp, for example, the presence of TNPs significantly enhanced accumulation of toxic metal ions in the viscera and gills [87]. Furthermore, TNPs passed through the blood-heart/brain barriers [88].…”

Section: Tnp Toxicity To Organisms In the Ecosystemmentioning

confidence: 99%

The potential health risk of titania nanoparticles

Zhang

Bai

Zhang

et al. 2012

Journal of Hazardous Materials

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Section: Tnp Toxicity To Organisms In the Ecosystemmentioning

confidence: 99%

The potential health risk of titania nanoparticles

Zhang

Bai

Zhang

et al. 2012

Journal of Hazardous Materials

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“…Short-term exposure of the zebrafish to TiO 2 NPs has very little toxic effect while long-term exposure led to serious damage of different organs. The gills, liver, brain, and growth rate affected due to long-time exposure (Chen et al 2011). About 29.5 % reduction in the zebrafish eggs' was observed after exposure of 13 days to TiO 2 NPs (Wang et al 2011).…”

Section: Effects On Aquatic Environmentmentioning

confidence: 98%

Impact of nanoparticles on human and environment: review of toxicity factors, exposures, control strategies, and future prospects

Sajid

Ilyas

Basheer

et al. 2014

Environ Sci Pollut Res

340

124

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Nanotechnology has revolutionized the world through introduction of a unique class of materials and consumer products in many arenas. It has led to production of innovative materials and devices. Despite of their unique advantages and applications in domestic and industrial sectors, use of materials with dimensions in nanometers has raised the issue of safety for workers, consumers, and human environment. Because of their small size and other unique characteristics, nanoparticles have ability to harm human and wildlife by interacting through various mechanisms. We have reviewed the characteristics of nanoparticles which form the basis of their toxicity. This paper also reviews possible routes of exposure of nanoparticles to human body. Dermal contact, inhalation, and ingestion have been discussed in detail. As very limited data is available for long-term human exposures, there is a pressing need to develop the methods which can determine short and long-term effects of nanoparticles on human and environment. We also discuss in brief the strategies which can help to control human exposures to toxic nanoparticles. We have outlined the current status of toxicological studies dealing with nanoparticles, accomplishments, weaknesses, and future challenges.

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“…tissue solubilization or ashing. It is also possible to undertake real-time imaging and to follow the biodistribution in vivo using techniques such as positron-emission tomography (PET), computed tomography (CT) and single photon emission computed tomography (SPECT) with appropriate labeling of NMs (Chen et al, 2011).…”

Section: Testing Methodsmentioning

confidence: 99%

Immunotoxicity, genotoxicity and epigenetic toxicity of nanomaterials: New strategies for toxicity testing?

Dušinská

Tulinská

Yamani

et al. 2017

Food and Chemical Toxicology

118

101

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a b s t r a c tThe unique properties of nanomaterials (NMs) are beneficial in numerous industrial and medical applications. However, they could also induce unintended effects. Thus, a proper strategy for toxicity testing is essential in human hazard and risk assessment. Toxicity can be tested in vivo and in vitro; in compliance with the 3Rs, alternative strategies for in vitro testing should be further developed for NMs. Robust, standardized methods are of great importance in nanotoxicology, with comprehensive material characterization and uptake as an integral part of the testing strategy. Oxidative stress has been shown to be an underlying mechanism of possible toxicity of NMs, causing both immunotoxicity and genotoxicity. For testing NMs in vitro, a battery of tests should be performed on cells of human origin, either cell lines or primary cells, in conditions as close as possible to an in vivo situation. Novel toxicity pathways, particularly epigenetic modification, should be assessed along with conventional toxicity testing methods. However, to initiate epigenetic toxicity screens for NM exposure, there is a need to better understand their adverse effects on the epigenome, to identify robust and reproducible causal links between exposure, epigenetic changes and adverse phenotypic endpoints, and to develop improved assays to monitor epigenetic toxicity.

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Effects of titanium dioxide nano-particles on growth and some histological parameters of zebrafish (Danio rerio) after a long-term exposure

Cited by 155 publications

References 31 publications

The potential health risk of titania nanoparticles

The potential health risk of titania nanoparticles

Impact of nanoparticles on human and environment: review of toxicity factors, exposures, control strategies, and future prospects

Immunotoxicity, genotoxicity and epigenetic toxicity of nanomaterials: New strategies for toxicity testing?

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