Effects of total glucosides of paeony on oxidative stress in the kidney from diabetic rats

Verification of the Antidiabetic Effects of Cinnamon (Cinnamomum zeylanicum) Using Insulin-Uncontrolled Type 1 Diabetic Rats and Cultured Adipocytes

“…The glomerular volume (V G ) was then calculated from the A G value by the equation, V G ¼ =K½A G 3=2 , where ¼ 1:38, the size distribution coefficient, and K ¼ 1:1, the shape coefficient for glomeruli idealized as spheres. 19) Cell culture. The 3T3-L1 fibroblasts were cultured and differentiation induced into adipocytes by the method described previously.…”

TGP attenuates endoplasmic reticulum stress and regulates the expression of thioredoxin-interacting protein in the kidneys of diabetic rats

“…Previous studies by the current authors indicated that the weight of the kidney, the glomerular volume, the tubulointerstitial damage index, and the rate of urinary albumin excretion improved markedly 8 weeks after diabetes was induced with STZ; however, TGP ameliorated albuminuria and it attenuated glomerular and tubulointerstitial injuries without changing blood glucose levels (24,25,31). This suggested that TGP might prove to be a useful therapy for DN.…”

“…Recently, TGP have been used to treat chronic nephritis in rats (22), and their action may involve the regulation of the expression of IL-1 and IL-1α mRNA (23). In previous studies, the current authors experimentally induced DN, and results indicated that TGP prevented inflammation, oxidation, and macrophage activation, thus slowing the progression of DN (24)(25)(26). However, the effect of TGP on the ERS-TXNIPinflammation chain in DN remains unclear.…”

Controversial effects of Calendula officinalis L. on Biochemical and Pathological Factors of Nephropathy in Diabetic Wistar Rats

“…It is supposed that several mechanisms originated from hyperglycemia such as advanced glycation end product formation, aldose reductase pathway, increased protein kinase C activity, over-activation of poly ADP-ribose polymerase inflammation, and oxidative stress are involved in the pathogenesis of DN and its complications (8,9). Increasing evidence suggests that there is a close connection between hyperglycemia, oxidative stress and diabetic complications, especially DN (5,9,10). Scientific studies suggest that antioxidants have favorable effects on experimental models of diabetes and human kidney (10).…”

“…Increasing evidence suggests that there is a close connection between hyperglycemia, oxidative stress and diabetic complications, especially DN (5,9,10). Scientific studies suggest that antioxidants have favorable effects on experimental models of diabetes and human kidney (10). Although angiotensin-converting enzyme (ACE) inhibi-tors and angiotensin II receptor blockers can ameliorate the progression of DN, there is no effective and specific treatment (11,12).…”