Effects of Vibration Therapy on Immobilization-Induced Hypersensitivity in Rats

Hamaue, Yohei; Nakano, Jun; Sekino, Yuki; Chuganji, Sayaka; Sakamoto, Juichi; Yoshimura, Tsuyoshi; Okita, Minoru; Origuchi, Tomoki

doi:10.2522/ptj.20140137

Cited by 14 publications

(25 citation statements)

References 53 publications

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“…In experimental studies using animal, cast immobilization of limbs causes hyperalgesia, which is a decline of the threshold of mechanical and thermal mechanical stimuli [1,2], and limb immobilization for long durations may induce chronic pain associated with central sensitization [3].…”

Section: Introductionmentioning

confidence: 99%

Hyperalgesia in an immobilized rat hindlimb: Effect of treadmill exercise using non-immobilized limbs

Chuganji

Nakano

Sekino

et al. 2015

Neuroscience Letters

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Cast immobilization of limbs causes hyperalgesia, which is a decline of the threshold of mechanical and thermal mechanical stimuli. The immobilization-induced hyperalgesia (IIH) can disturb rehabilitation and activities of daily living in patients with orthopedic disorders. However, it is unclear what therapeutic and preventive approaches can be used to alleviate IIH. Exercise that activates the descending pain modulatory system may be effective for IIH. The purpose of this study was to investigate the effects of treadmill exercise during the immobilization period, using the non-immobilized limbs, on IIH. Thirty-six 8-week-old Wistar rats were randomly divided into 1) control, 2) immobilization (Im), and 3) immobilization and treadmill exercise (Im+Ex) groups. In the Im and Im+Ex groups, the right ankle joints of each rat were immobilized in full plantar flexion with a plaster cast for an 8-week period. In the Im+Ex group, treadmill exercise (15 m/min, 30 min/day, 5 days/week) was administered during the immobilization period while the right hindlimb was kept immobilized. Mechanical hyperalgesia was measured using von Frey filaments every week. To investigate possible activation of the descending pain modulatory system, beta-endorphin expression levels in hypothalamus and midbrain periaqueductal gray were analyzed. Although IIH clearly occurred in the Im group, the hyperalgesia was partially but significantly reduced in the Im+Ex group. Beta-endorphin, which is one of the endogenous opioids, was selectively increased in the hypothalamus and midbrain periaqueductal gray of the Im+Ex group. Our data suggest that treadmill running using the non-immobilized limbs reduces the amount of hyperalgesia induced in the immobilized limb even if it is not freed. This ameliorating effect might be due to the descending pain modulatory system being activated by upregulation of beta-endorphin in the brain.

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Section: Introductionmentioning

confidence: 99%

Hyperalgesia in an immobilized rat hindlimb: Effect of treadmill exercise using non-immobilized limbs

Chuganji

Nakano

Sekino

et al. 2015

Neuroscience Letters

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“…Further, Hamaue et al claimed that only a 4-week immobilization resulted in hypersensitivity [ 18 ]. In this study, however, we did not observe any changes in the sensory threshold even without vibration ( Fig 3D ) [ 21 ]. The casting and non-weight-bearing conditions did not cause hypersensitivity in the acute stage after cast removal, even after 6 weeks of immobilization, probably due to the measurement of the sensory threshold.…”

Section: Discussionmentioning

confidence: 63%

“…Previous studies have showed that immobilization in rodents causes hypersensitivity [ 17 – 20 ] and that continuous vibration or treadmill training partially recovers the hypersensitivity [ 21 – 23 ]. Further, Hamaue et al claimed that only a 4-week immobilization resulted in hypersensitivity [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

“…The casting and non-weight-bearing conditions did not cause hypersensitivity in the acute stage after cast removal, even after 6 weeks of immobilization, probably due to the measurement of the sensory threshold. Moreover, Hamaue et al used the von-Frey filament for threshold measurement [ 21 ], whereas, we utilized the electro-stimulus. Further, in this study, we only used 2000 Hz as the frequency for the electro-stimulation.…”

Section: Discussionmentioning

confidence: 99%

“…Regarding basic research of the vibratory stimulus for immobilization rat model, papers have reported that local vibration affect sensory function [ 10 ]. Further, in terms of clinical research of the vibratory stimulus for patients, such as chronic obstructive pulmonary disease, and stroke, a couple of papers have already stated that both whole-body and local vibration affects motor performance [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

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Sole vibration improves locomotion through the recovery of joint movements in a mouse cast model

Doi

Miyamoto²,

Nakano³

et al. 2017

PLoS ONE

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We investigated the effects of a vibratory stimulus on the plantar surface of the hind limb for motor, sensory, and locomotive function using a mouse cast model. The right knee joint of C57BL/6 male mice (7 weeks, 20 g, n = 31) was flexed with aluminum splint and tape for 6 weeks. These mice were randomly divided into 2 groups (control group, n = 11 and vibration group, n = 12). The mice in the vibration group received vibration on the sole of the ankle for 15 minutes per day, 5 days per week. After the knee joint cast was removed, we measured the range of motion (ROM) of both knee and ankle joints and the sensory threshold of the sole. Further, both walking and swimming movements were analyzed with a digital video. The sole vibration did not affect the passive ROM of the knee joint and sensory threshold after cast removal. However, it increased the ankle dorsiflexion range and improved free walking, swimming, and active movement of the knee joint. In conclusion, we show that the vibration recovered both walking and swimming movements, which resulted from improvements in both the passive ankle dorsiflexion and active knee movement.

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Beneficial effects of whole-body vibration exercise for brain disorders in experimental studies with animal models: a systematic review

Cardoso

Sá-Caputo

Asad

et al. 2022

Behavioural Brain Research

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Effects of Vibration Therapy on Immobilization-Induced Hypersensitivity in Rats

Abstract: The data suggest that initiation of vibration therapy in the early phase of immobilization may inhibit the development of immobilization-induced hypersensitivity.

Cited by 14 publications

References 53 publications

Hyperalgesia in an immobilized rat hindlimb: Effect of treadmill exercise using non-immobilized limbs

Hyperalgesia in an immobilized rat hindlimb: Effect of treadmill exercise using non-immobilized limbs

Sole vibration improves locomotion through the recovery of joint movements in a mouse cast model

Beneficial effects of whole-body vibration exercise for brain disorders in experimental studies with animal models: a systematic review

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