Effects ofFomitopsis pinicola extracts on antioxidant and antitumor activities

Choi, DuBok; Park, Sang‐Shin; Ding, Junqiang; Cha, Wol-Suk

doi:10.1007/bf02931349

Cited by 48 publications

(42 citation statements)

References 25 publications

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“…More and more studies have revealed that free radicals, produced by cellular metabolism and derived from exposure to environmental pro-oxidants, are implicated in the development of chronic and degenerative diseases such as mutagenesis, carcinogenesis, coronary heart disease, diabetes, Parkinson's and Alzheimer's disease via free-radical damage to lipids, nucleic acids, and proteins [3][4][5]. The fact that the risk of such chronic diseases is inversely related to the intake of dietary antioxidants accelerates the search of potential antioxidants from vegetables, fruits, medicinal plants, seaweeds, and so on [6][7][8].…”

Section: Introductionmentioning

confidence: 98%

Ishigoside, a new glyceroglycolipid isolated from the brown alga Ishige okamurae

Zou

Kim

et al. 2009

Biotechnol Bioproc E

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A new glyceroglycolipid, ishigoside (1, 2-di-O-palmitoyl-3-O-(6-deoxy-6-amino)-α-D-glucopyranosyl-glycerol, 1), along with two known compounds were isolated from the brown alga Ishige okamurae. The structure of the new compound was determined on the basis of spectroscopic analysis, including 1D and 2D NMR, MS techniques and chemical methods. Moreover, direct free radical scavenging activities of ishigoside were investigated by electron spin resonance spectrometry (ESR) technique. The results suggested that ishigoside was a potential free-radical scavenger against DPPH, hydroxyl, alkyl, and superoxide radicals with the EC 50 of 31.2, 16.7, 22.7, and 26.8 μM, respectively. © KSBB

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Section: Introductionmentioning

confidence: 98%

Ishigoside, a new glyceroglycolipid isolated from the brown alga Ishige okamurae

Zou

Kim

et al. 2009

Biotechnol Bioproc E

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“…Medicinal fungus (Fomitopsis pinicola) is used extensively in the health sector due to its important chemical compounds (lanostane triterpenoids, triterpene glycosides and steroids) and antimicrobial, antitumor and antioxidant activities [1][2][3][4][5]. Additionally, it can be used as a nutritional supplement and as a therapeutic substance [5].…”

Section: Introductionmentioning

confidence: 99%

Physicochemical Properties of Chitin and Chitosan Produced from Medicinal Fungus (Fomitopsis pinicola)

et al. 2014

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Fomitopsis pincola, which is used as a medicinal fungus in Asia, is widespread throughout the temperate Northern Hemisphere. The fungus's chitin structure was isolated and characterized in this study. It was found that 30.11 % of the dry weight of the fungus consisted of chitin, a very high portion. The chitosan yield from the chitin was 71.75 %. It was calculated that chitin acetylation was 72.5 % and that deacetylation of chitosan was 73.1 %. The maximum temperature of degradation (DTGmax) recorded for the chitin was 341°C and was 265°C for chitosan. The crystalline index (CrI) value of the chitin was 52 %, while it was 41 % for the chitosan. Examination by SEM revealed that the surface morphologies of the chitin and chitosan were formed of nanofibre structures. The FTIR examination identified it as the α form of chitin. As F. pinicola is widespread, abundant and has a high chitin and chitosan content, it may be used as an alternative chitin and chitosan source.

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“…Recently, interest has increased considerably in finding naturally occurring antioxidant for use in foods or medicinal materials to replace synthetic antioxidants, which are being restricted due to their side effects such as carcinogenicity. Natural antioxidants can protect the human body from free radicals and retard the progress of many chronic diseases as well as retard lipid oxidative rancidity in foods or medicinal materials [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Free radical and reactive oxygen species scavenging activities of the extracts from seahorse, Hippocampus kuda Bleeler

Qian

Ryu

Kim

et al. 2008

Biotechnol Bioproc E

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Seahorse, Hippocampus kuda (SH) a marine teleost fish, is well known not only for its special medicinal composition and used as one of the most famous and expensive materials of traditional Chinese medicine. It was extracted with water (SHW), methanol (SHM), and ethanol (SHE), respectively and evaluated by various antioxidant assays. The including reducing power, total antioxidant, DPPH radical scavenging, hydroxyl radical scavenging, superoxide anion radical scavenging, alkyl radical scavenging, and protective effect on DNA damage caused by hydroxyl radicals generated. Further, the ROS level was detected using a fluorescence probe, 2′,7′-dichlorofluorescin diacetate (DCFH-DA), which could be converted to highly fluorescent dichlorofluorescein (DCF) with the presence of intracellular ROS on mouse macrophages, RAW264.7 cell and inhibited myeloperoxidase (MPO) activity in human myeloid, HL60 cells, respectively. Those various antioxidant activities were compared to standard antioxidants such as α-tocopherol. Among SHM exhibited the highest antioxidant activity in linoleic acid system, effective reducing power, DPPH radical scavenging, hydroxyl radical scavenging, superoxide radical scavenging, alkyl radical scavenging, inhibitory intracellular ROS, and inhibited MPO activity. Furthermore, MTT assay showed no cytotoxicity on mouse macrophages cell (RAW264.7) and human cell lines (MRC-5, HL60, U937). This antioxidant property depends on concentration and increasing with increased amount of extracts. The results obtained in the present study indicated that the see horse (Hippocampus kuda Bleeker) is a potential source of natural antioxidant. © KSBB

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Effects ofFomitopsis pinicola extracts on antioxidant and antitumor activities

Cited by 48 publications

References 25 publications

Ishigoside, a new glyceroglycolipid isolated from the brown alga Ishige okamurae

Ishigoside, a new glyceroglycolipid isolated from the brown alga Ishige okamurae

Physicochemical Properties of Chitin and Chitosan Produced from Medicinal Fungus (Fomitopsis pinicola)

Free radical and reactive oxygen species scavenging activities of the extracts from seahorse, Hippocampus kuda Bleeler

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