Ishigoside, a new glyceroglycolipid isolated from the brown alga Ishige okamurae

Zou, Yanping; Li, Yong; Kim, Moon‐Moo; Lee, Sanghoon; Kim, Se‐Kwon

doi:10.1007/s12257-008-0131-3

Cited by 23 publications

(13 citation statements)

References 26 publications

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“…IO is an edible brown seaweed that grows on rocks in the upper and middle intertidal zones in the northwest Pacific Ocean (Korea, Japan, and China), where it forms continuous bands [20]. As shown in Table 2, previous studies have discussed the usefulness of bioactive compounds from IO as functional ingredients [49,58,74]. Additionally, the antioxidant properties of the methanol extract and enzymatic extract from IO were evaluated to develop potential functional food materials against oxidative stress [21,26].…”

Section: Potential Nutraceutical Use Of Iomentioning

confidence: 99%

Anti-Obesity and Anti-Diabetic Effects of Ishige okamurae

Yang

Fernando

et al. 2019

Marine Drugs

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Obesity is associated with several health complications and can lead to the development of metabolic syndrome. Some of its deleterious consequences are related to insulin resistance, which adversely affects blood glucose regulation. At present, there is a growing concern regarding healthy food consumption, owing to awareness about obesity. Seaweeds are well-known for their nutritional benefits. The brown alga Ishige okamurae (IO) has been studied as a dietary supplement and exhibits various biological activities in vitro and in vivo. The bioactive compounds isolated from IO extract are known to possess anti-obesity and anti-diabetic properties, elicited via the regulation of lipid metabolism and glucose homeostasis. This review focuses on IO extract and its bioactive compounds that exhibit therapeutic effects through several cellular mechanisms in obesity and diabetes. The information discussed in the present review may provide evidence to develop nutraceuticals from IO.

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Section: Potential Nutraceutical Use Of Iomentioning

confidence: 99%

Anti-Obesity and Anti-Diabetic Effects of Ishige okamurae

Yang

Fernando

et al. 2019

Marine Drugs

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“…DPPH radical was measured using the method previously described [15]. Sixty microliters of A. dilatata extract in ethanol (or ethanol itself as a control) were added to 60 µL of DPPH (60 µM) in ethanol solution and vortexed for 10 sec.…”

Section: Determination Of Dpph Radical Scavenging Activity By Esr Spementioning

confidence: 99%

Protective effect of Amphiroa dilatata on ROS induced oxidative damage and MMP expressions in HT1080 cells

Khan

Kong

Kim

et al. 2010

Biotechnol Bioproc E

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Antioxidative and matrix metalloproteinase (MMP) inhibitory effects of methanolic extract from ^ãéÜáêç~=Çáä~í~í~ were investigated in HT1080 cells. Treatment with ^K=Çáä~í~í~ extract suppressed the intensity of electron spin resonance signal on the generation of DPPH radicals in a cell-free system and intracellular reactive oxygen species (ROS) formation by 2′,7′-dichlorofluorescin diacetate (DCFH-DA). Radical simulated oxidation of membrane proteins and lipids were also inhibited by treatment with ^K=Çáä~í~í~ extract in a concentration-dependent manner. In addition, a protective effect on oxidative damage of purified genomic DNA was observed in the presence of ^K=Çáä~í~í~ extract. These results revealed that ^K=Çáä~í~í~ has an excellent scavenging ability on ROS-induced oxidative damage. Moreover, this extract reduced the expression levels of MMP-2 and -9 in gelatin zymography, and RT-PCR analysis without any cytotoxic influence. Therefore, ^K= Çáä~í~í~ has a promising potential as a valuable source to be used as ingredient in functional foods, related to oxidative damage. © KSBB hÉóïçêÇëW=Amphiroa dilatata, jjmJOI=jjmJVI=êÉ~ÅíáîÉ=çñóÖÉå=ëéÉÅáÉë= = = = =

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“…Apparently, that many structurally diverse substances of algae have ability to anti-inflammatory effect. At the same time, similar information about of algae lipids is extremely small [30]- [34], especially for brown algae [30] [33]. So, recently has been showed, that monogalactosyldiacylglycerols and monoacylglycerol from brown alga Fucus spiralis have strong NO inhibitory activity against LPS-induced NO production in murine RAW264.7 cells [33] and glyceroglycolipid ishigoside of Ishige okamurae is a potential free-radical scavenger against DPPH, hydroxyl, alkyl, and superoxide radicals [30].…”

Section: Introductionmentioning

confidence: 99%

Application of Glyceroglycolipids, Photosynthetic Pigments and Extracts of Brown Algae for Suppression ROS

Gerasimenko¹,

Menchinskaya²,

Esipov³

et al. 2016

OJMS

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Lipid-rich extracts were obtained from brown algae Saccharina cichorioides, Costaria costata, Chorda filum, Eularia fistulosa, Dictyopteris divaricata, Dictyosiphon chordaria, Silvetia babingtonii, and Fucus evanescens that were collected in Peter the Great Gulf of the Sea of Japan. The ability of algal extracts and glyceroglycolipids (GLs) monogalactosyldiacylglycerols (MGDG), digalactosyldiacylglycerols (DGDG), and sulfoquinovosyldiacylglycerols (SQDG) and carotenoid fucoxanthin to suppression of reactive oxygen species (ROS) in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells, studied.The results showed that algae extracts could suppress ROS. However, extracts of D. divaricata, D. chordaria, C. filum, S. babingtonii, and F. evanescens had a higher degree of suppression of ROS. Extracts of S. cichorioides and D. divaricata showed the dependence of their activity from the month of collecting these algae. The GLs and fucoxanthin were isolated from extracts of using column chromatography with silica gel and their ROS-inhibitory activity was investigated too. The fatty acids (FAs) composition of lipids was determined by GC and GC/MS. It has been found that MGDG and DGDG stronger than SGDG inhibited the ROS and the degree of their activity depended on the species of algae, the month of collection, the amount of PUFA, the ratio of n − 3 and n − 6 PUFA in GLs. Fucoxanthin has shown a high degree of suppression of ROS. This preliminary study has shown the prospect of a deeper study of the suppression of ROS with the help of lipids from algae the Sea of Japan.

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Ishigoside, a new glyceroglycolipid isolated from the brown alga Ishige okamurae

Cited by 23 publications

References 26 publications

Anti-Obesity and Anti-Diabetic Effects of Ishige okamurae

Anti-Obesity and Anti-Diabetic Effects of Ishige okamurae

Protective effect of Amphiroa dilatata on ROS induced oxidative damage and MMP expressions in HT1080 cells

Application of Glyceroglycolipids, Photosynthetic Pigments and Extracts of Brown Algae for Suppression ROS

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