Efficacy and safety of Chinese herbal medicine Buzhong Yiqi decoction for postmenopausal women with osteoporosis: A protocol for systematic review and meta-analysis

Abstract

Background: Postmenopausal osteoporosis (PMOP) is a disorder of bone metabolism caused by estrogen deficiency in women after menopause, which manifests clinically as pain, spinal deformities, and even fragility fractures, affecting the quality of life of patients and possibly shortening their life span. Traditional Chinese medicine prescription Buzhong Yiqi Decoction (BZYQD) has been widely used in clinical practice and achieved good results. But there is no high-level evidence to support this result. The aim of this study is to evaluate BZYQD's efficacy and safety in the management of PMOP.Methods: We will search articles in 7 electronic databases including Chinese National Knowledge Infrastructure, Wanfang Data, Chinese Scientific Journals Database, Chinese databases SinoMed, PubMed, Embase, and Cochrane Library databases. All the publications, with no time restrictions, will be searched without any restriction on language and status, the time from the establishment of the database to September 2022. Two reviewers will independently assess the quality of the selected studies, NoteExpress and Excel software will be used to extract data, and the content will be stored in an electronic chart. Different researchers will separately screen the titles and abstracts of records acquired potential eligibility which comes from the electronic databases. Full-text screening and data extraction will be conducted afterward independently. Statistical analysis will be conducted using RevMan 5.4 software.Results: This study will evaluate the efficacy and safety of BZYQD in the treatment of PMOP, to provide high-quality, evidencebased clinical recommendations. Conclusion:The study provides a trustable clinical foundation for BZYQD in the treatment of PMOP.

A comprehensive strategy for prediction and quality evaluation of standardized planting herbs based on plant metabolomics coupled with extreme learning machine: Astragali Radix as an example

“…The weight coefficients of the four items were set as 0.2, 0.4, 0.2, and 0.2, respectively, with three components accounting for 0.2 each in view of their contributions to the quality of AR. "Affiliation degree" was invoked in the data processing to score the positively correlated items, as demonstrated in Equation (1), where the index value is the actual value in the content determination, the index value max is the maximum measured value in that item, and the index value min is the maximum measured value in that item. The negatively correlated indicators were scored by "specific gravity" (see Equation ( 2)), where the standard value was the upper limit of the content in the pharmacopoeia and the index value was the same as above.…”

“…Bunge or Astragalus mongholicus Bunge, is an edible and medicinal herb that has been commonly used for over 2000 years in China. As the “most classic tonic” drug, AR can be used as a main ingredient in formulas, 1 or it can be boiled instead of tea or stewed with medicinal herbs in daily life to tonify Qi and strengthen the body 2 . Modern pharmacological studies have revealed that AR can improve the immune function of the body and that it exerts anti‐fatigue, anti‐aging, and anti‐tumor effects 3–6 .…”