Electrochemical molecularly imprinted polymer based sensors for pharmaceutical and biomedical applications (review)

Ramanavičius, Simonas; Samukaitė-Bubnienė, Urtė; Ratautaitė, Vilma; Bechelany, Mikhael; Ramanavičius, Arūnas

doi:10.1016/j.jpba.2022.114739

Cited by 49 publications

(26 citation statements)

References 272 publications

(333 reference statements)

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“…In short, many kinds of MIP-based biosensor analysis developments have been reported for special targets such as paracetamol (acetaminophen) in plasma (Alanazi et al 2021 ), glycoprotein in human serum sample (You et al 2017 ), uric acid in serum and urine (Göçenoğlu Sarıkaya et al 2017 ), heart-fatty acid binding protein in human serum, human plasma, and bovine serum (Sanati et al 2021 ), β ‑amyloid in serum (Pereira et al 2020 ) and α synuclein in human brain organoids (Lee et al 2020 ) with high accuracy and recovery which may lead to clinical usage as fast and reproducible approaches. The use of MIPs in biological sensing has also been the subject of recent several review studies (Batista et al 2021 ; Kadhem et al 2021 ; Ramanavicius et al 2022 ) (Fig. 9 ).…”

Section: Mip In Bioanalysismentioning

confidence: 98%

Recent molecularly imprinted polymers applications in bioanalysis

Suzaei¹,

Daryanavard

Abdel-Rehim

et al. 2022

Chem. Pap.

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Molecular imprinted polymers (MIPs) as extraordinary compounds with unique features have presented a wide range of applications and benefits to researchers. In particular when used as a sorbent in sample preparation methods for the analysis of biological samples and complex matrices. Its application in the extraction of medicinal species has attracted much attention and a growing interest. This review focus on articles and research that deals with the application of MIPs in the analysis of components such as biomarkers, drugs, hormones, blockers and inhibitors, especially in biological matrices. The studies based on MIP applications in bioanalysis and the deployment of MIPs in high-throughput settings and optimization of extraction methods are presented. A review of more than 200 articles and research works clearly shows that the superiority of MIP techniques lies in high accuracy, reproducibility, sensitivity, speed and cost effectiveness which make them suitable for clinical usage. Furthermore, this review present MIP-based extraction techniques and MIP-biosensors which are categorized on their classes based on common properties of target components. Extraction methods, studied sample matrices, target analytes, analytical techniques and their results for each study are described. Investigations indicate satisfactory results using MIP-based bioanalysis. According to the increasing number of studies on method development over the last decade, the use of MIPs in bioanalysis is growing and will further expand the scope of MIP applications for less studied samples and analytes.

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Section: Mip In Bioanalysismentioning

confidence: 98%

Recent molecularly imprinted polymers applications in bioanalysis

Suzaei¹,

Daryanavard

Abdel-Rehim

et al. 2022

Chem. Pap.

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“…The resulting films can combine electron conductivity with weak polybase characteristics, conferring them with doping, complexation, and molecular imprinting abilities. A large number of recent studies have used these appealing properties to design sensors, energy devices, light-emitting devices, and electrochromic and “smart” electrodes, as described in recent reviews [ 72 , 73 , 74 , 75 , 76 ]. The presence of aromatic cycles in such polymers also confers them with a hydrophobic character and self-assembling properties that enable them not only to act as weak polyelectrolytes but also as structure directing nano-units ( Figure 2 B).…”

Section: Weak Polyelectrolytes Layers For Stimuli-responsive Surfacesmentioning

confidence: 99%

Weak Polyelectrolytes as Nanoarchitectonic Design Tools for Functional Materials: A Review of Recent Achievements

et al. 2022

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The ionization degree, charge density, and conformation of weak polyelectrolytes can be adjusted through adjusting the pH and ionic strength stimuli. Such polymers thus offer a range of reversible interactions, including electrostatic complexation, H-bonding, and hydrophobic interactions, which position weak polyelectrolytes as key nano-units for the design of dynamic systems with precise structures, compositions, and responses to stimuli. The purpose of this review article is to discuss recent examples of nanoarchitectonic systems and applications that use weak polyelectrolytes as smart components. Surface platforms (electrodeposited films, brushes), multilayers (coatings and capsules), processed polyelectrolyte complexes (gels and membranes), and pharmaceutical vectors from both synthetic or natural-type weak polyelectrolytes are discussed. Finally, the increasing significance of block copolymers with weak polyion blocks is discussed with respect to the design of nanovectors by micellization and film/membrane nanopatterning via phase separation.

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“…Moreover, these commercial sensors are based on enzymes, colloidal gold, or antibodies, with the main disadvantage for these being their limited stability, thus leading to relatively short shelf-life and the need for storing the sensor at determined temperatures and conditions. Biosensors could offer a low-cost alternative and in recent years, biosensors based on so-called molecularly imprinted polymers (MIPs) have specifically gained attention [ 17 , 18 , 19 , 20 ]. MIPs are synthetic receptors capable of selectively binding to a target through a “lock and key” mechanism and, as such, are considered synthetic substitutes of natural antibodies [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

A Molecularly Imprinted Polymer-Based Thermal Sensor for the Selective Detection of Melamine in Milk Samples

Caldara

Lowdon

Royakkers

et al. 2022

Foods

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In recent years, melamine-sensing technologies have increasingly gained attention, mainly due to the misuse of the molecule as an adulterant in milk and other foods. Molecularly imprinted polymers (MIPs) are ideal candidates for the recognition of melamine in real-life samples. The prepared MIP particles were incorporated into a thermally conductive layer via micro-contact deposition and its response towards melamine was analyzed using the heat-transfer method (HTM). The sensor displayed an excellent selectivity when analyzing the thermal response to other chemicals commonly found in foods, and its applicability in food safety was demonstrated after evaluation in untreated milk samples, demonstrating a limit of detection of 6.02 μM. As the EU/US melamine legal limit in milk of 2.5 mg/kg falls within the linear range of the sensor, it can offer an innovative solution for routine screening of milk samples in order to detect adulteration with melamine. The results shown in this work thus demonstrate the great potential of a low-cost thermal platform for the detection of food adulteration in complex matrices.

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Electrochemical molecularly imprinted polymer based sensors for pharmaceutical and biomedical applications (review)

Cited by 49 publications

References 272 publications

Recent molecularly imprinted polymers applications in bioanalysis

Recent molecularly imprinted polymers applications in bioanalysis

Weak Polyelectrolytes as Nanoarchitectonic Design Tools for Functional Materials: A Review of Recent Achievements

A Molecularly Imprinted Polymer-Based Thermal Sensor for the Selective Detection of Melamine in Milk Samples

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