The possibilities of enhancing the electron mobility and high-field drift velocity in channels of modulation-doped InAlAs/InGaAs and AlGaAs/InGaAs quantum wells by tuning interaction of electrons with interface phonons are tested and reviewed. A large increase in the mobility is achieved in a novel metamorphic In 0.7 Al 0.3 As/In 0.8 Ga 0.2 As structure with the high InAs content in the InAlAs barrier layer as well as in the Al x Ga 1-x As/In 0.2 Ga 0.8 As structure with the low AlAs content in the AlGaAs barrier layer. An enhancement in the electron mobility by inserting thin InAs layers into the In 0.52 Al 0.48 As/In 0.53 Ga 0.47 As quantum well is obtained. The electron drift velocity saturates at high electric fields of 1.5-5 kV/cm and achieves a maximal value of 2.5 . 10 7 cm/s in the InGaAs quantum well with the thin InAs and GaAs inserts.