Electrospinning production of nanofibrous membranes

Mishra, Raghvendra Kumar; Mishra, Prachi; Verma, Kartikey; Mondal, Aniruddha; Chaudhary, Ratiram Gomaji; Abolhasani, Mohammad Mahdi; Loganathan, Sravanthi

doi:10.1007/s10311-018-00838-w

Cited by 147 publications

(51 citation statements)

References 283 publications

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“…Tensile strength of human skin is in the range 2-16 MPa and its elongation-at-break in the 70-77 % range. 46 One of the significant features of PCL for biomedical application is its high elongation-at-break, 47 in our case, the measured value of 108.6 ± 11.3 % is much higher than the one of the human skin. The tensile strength retrieved of 5.1 ± 0.5 MPa would be also in the required range for wound dressing applications.…”

Section: Resultsmentioning

confidence: 63%

Efficiency of Antimicrobial Electrospun Thymol-Loaded Polycaprolactone Mats In Vivo

García-Salinas

Gámez

Asín

et al. 2020

ACS Appl. Bio Mater.

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Due to the prevalence of antimicrobial resistant pathogens, natural products with long-term antimicrobial activities are considered as potential alternatives. In this work, polycaprolactone (PCL) electrospun fibers with mean diameters around 299 nm and loaded with 14.92 ± 1.31% w/w thymol (THY) were synthesized. The mats had appropriate elongation at break (74.4 ± 9.5%) and tensile strength (3.0 ± 0.5 MPa) to be potentially used as wound dressing materials. In vivo studies were performed using eight to ten week-old male SKH1 hairless mice. The infection progression was evaluated through a semiquantitative method and quantitative polymerase chain reaction. The analyses of postmortem samples indicated that THY-loaded PCL fibers acted as inhibitors of Staphylococcus aureus ATCC 25923 strain growth being as efficient as chlorhexidine (CLXD). Histopathological and immunohistochemical studies showed that the PCL-THY-treated wounds were almost free of an inflammatory reaction. Therefore, wound dressings containing natural compounds can prevent infection and promote wound healing and prompt regeneration.

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Section: Resultsmentioning

confidence: 63%

Efficiency of Antimicrobial Electrospun Thymol-Loaded Polycaprolactone Mats In Vivo

García-Salinas

Gámez

Asín

et al. 2020

ACS Appl. Bio Mater.

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“…Natural fibers, especially silk, are also appealing materials for bioinspired spinning methods for many biomedical applications [ 67 ]. Electrospinning, or electrostatic spinning, consists of providing an electrical field to obtain polymer filaments by a polymer solution, properly controlling morphology and parameters [ 68 ] and, for silk spinning, it consists of obtaining silk filaments continuously by means of a fluid forced through a spinneret, by properly monitoring physicochemical parameters, geometry and the shear forces involved [ 67 ]. Although some challenges are still related to the use of toxic solvents and pollution, during the past ten years electrospinning techniques have attracted great attention for the development of bioinspired materials [ 69 ].…”

Section: Silk Fibroin As a Nature Derived Materials For Wound Healimentioning

confidence: 99%

Bioinspired Materials for Wound Healing Application: The Potential of Silk Fibroin

Pollini

Paladini

2020

Materials

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Nature is an incredible source of inspiration for scientific research due to the multiple examples of sophisticated structures and architectures which have evolved for billions of years in different environments. Numerous biomaterials have evolved toward high level functions and performances, which can be exploited for designing novel biomedical devices. Naturally derived biopolymers, in particular, offer a wide range of chances to design appropriate substrates for tissue regeneration and wound healing applications. Wound management still represents a challenging field which requires continuous efforts in scientific research for definition of novel approaches to facilitate and promote wound healing and tissue regeneration, particularly where the conventional therapies fail. Moreover, big concerns associated to the risk of wound infections and antibiotic resistance have stimulated the scientific research toward the definition of products with simultaneous regenerative and antimicrobial properties. Among the bioinspired materials for wound healing, this review focuses attention on a protein derived from the silkworm cocoon, namely silk fibroin, which is characterized by incredible biological features and wound healing capability. As demonstrated by the increasing number of publications, today fibroin has received great attention for providing valuable options for fabrication of biomedical devices and products for tissue engineering. In combination with antimicrobial agents, particularly with silver nanoparticles, fibroin also allows the development of products with improved wound healing and antibacterial properties. This review aims at providing the reader with a comprehensive analysis of the most recent findings on silk fibroin, presenting studies and results demonstrating its effective role in wound healing and its great potential for wound healing applications.

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“…Thermal stability and the electrical conductivities Biosensors, sensors etc. The increment of rGO (1% wt) improved PVA NF properties due to the strong interfacial interaction between rGO and PVA rGO dispersion in the PVA solution did not alter the crystal structure of PVA [ 35 ] Ag/rGO/Polyamide (PI) (20 kV; DMAc: THF = 3:2, wt:wt% Stirring The λ, Tg and THRI values of the (Ag/rGO)/PI nanocomposites were all increased with increasing the Ag/rGO filler loading – The aggregation of rGO can be effectively restricted by introducing Ag nanoparticles – [ 43 ] PVDF-Pt–Pd/RGO-CeO2 15 cm; 12 kV; 1 mL/h Increased thermal and catalytic properties DMFC applications Novel electrospinning of PVDF-Pt–Pd/RGO-CeO2 nanocomposites [ 44 ] GO-doped PVDF/CuO/Al 15 cm; 0.07 mm/min Heat of reaction and reaction efficiency of PVDF/CuO/Al nanocomposites Strong anti-oxidation capability – Electrospinning and GO doping can improve the reaction efficiency due to the improvement of microstructure quality and nanocomposites performance [ 45 ] PU and PU/rGO‐Ag 17 cm; 18 kV; 0.3 mL/h Tensile strength Electrical conductivity Cardiogenic differentiation Potential Wettability Cardiac tissue engineering Adding rGO‐Ag and concentration influence the fiber diameter and the final properties [ 46 ] MnO2-GO 10 cm; 15 kV; 0.5 mL/h Electrochemical dielectric behaviors higher charge mobility, diffusivity, and conductivity. Future energy storage devices – [ 47 ] PCL/GO-Gelatin 13 cm; 14 kV; 3 mL/h Tensile stress and Young’s modulus Anti-tumor effect of classical therapies …”

Section: Properties Of Electrospun Gnms Nanocompositesmentioning

confidence: 99%

“…ESNFs diameter and morphology play an essential role in constructing biosensors and are controlled by the process parameters (applied voltage, receiving distance and feed rate), solution and solvent conditions (viscosity, concentration, conductivity, surface tension, volatility) and ambient conditions (humidity, temperature, pressure) [28]. Electrospinning has been extensively reviewed with respect to its development, principle and fundamentals, and the critical parameters influencing the fiber diameter and morphology in several recent reviews such as [34,[39][40][41][42][43][44][45].…”

Section: Introductionmentioning

confidence: 99%

Graphene impregnated electrospun nanofiber sensing materials: a comprehensive overview on bridging laboratory set-up to industry

2020

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Owing to the unique structural characteristics as well as outstanding physio-chemical and electrical properties, graphene enables significant enhancement with the performance of electrospun nanofibers, leading to the generation of promising applications in electrospun-mediated sensor technologies. Electrospinning is a simple, cost-effective, and versatile technique relying on electrostatic repulsion between the surface charges to continuously synthesize various scalable assemblies from a wide array of raw materials with diameters down to few nanometers. Recently, electrospun nanocomposites have emerged as promising substrates with a great potential for constructing nanoscale biosensors due to their exceptional functional characteristics such as complex pore structures, high surface area, high catalytic and electron transfer, controllable surface conformation and modification, superior electric conductivity and unique mat structure. This review comprehends graphene-based nanomaterials (GNMs) (graphene, graphene oxide (GO), reduced GO and graphene quantum dots) impregnated electrospun polymer composites for the electro-device developments, which bridges the laboratory setup to the industry. Different techniques in the base polymers (preprocessing methods) and surface modification methods (post-processing methods) to impregnate GNMs within electrospun polymer nanofibers are critically discussed. The performance and the usage as the electrochemical biosensors for the detection of wide range analytes are further elaborated. This overview catches a great interest and inspires various new opportunities across a wide range of disciplines and designs of miniaturized point-of-care devices.

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Electrospinning production of nanofibrous membranes

Cited by 147 publications

References 283 publications

Efficiency of Antimicrobial Electrospun Thymol-Loaded Polycaprolactone Mats In Vivo

Efficiency of Antimicrobial Electrospun Thymol-Loaded Polycaprolactone Mats In Vivo

Bioinspired Materials for Wound Healing Application: The Potential of Silk Fibroin

Graphene impregnated electrospun nanofiber sensing materials: a comprehensive overview on bridging laboratory set-up to industry

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