Electrospun composite nanofibers containing nanoparticles for the programmable release of dual drugs

Abstract

In this study, electrospun composite nanofibers containing nanoparticles for the programmable release of dual drugs were successfully fabricated through a one-step, single-nozzle electrospinning technique. Field-emission scanning electron microscopy and scanning electron microscopy were used to examine the morphology of the nanoparticles and electrospun nanofibers, respectively. The distribution of nanoparticles in the composite nanofibers was evaluated by fluorescence microscopy and laser scanning confocal microscopy. The results indicate that the nanoparticles were encapsulated within the composite nanofibers, forming a core-sheath structure. The different release behaviors of the drugs were ascribed to their varying distribution in the nanofibers and their interaction with carriers. A programmable release of both drugs was also achieved by adjusting the preparation process of the electrospinning solution. Composite nanofibers that can provide a platform for dual-drug loading and the programmed release of each drug may find application in drug delivery systems or in the tissue-engineering field.

Structural stability and sustained release of protein from a multilayer nanofiber/nanoparticle composite

“…They were linearly packed and aligned along the axes of the fibers, which is related to the viscosity gradient of the suspension during the electrospinning process. Similar results were reported by Wang and Norouzi et al for emulsion electrospinning [30,31]. containing chitosan nanoparticles was attributed only to chitosan degradation [34,[49][50][51].…”

“…In the present work, a system of core-shell structured nanofibers containing BSA-loaded nanoparticles was developed by suspension electrospinning to construct a bioactive scaffold with better protein structural preservation compared to common emulsion electrospinning techniques [31][32][33]. M a n u s c r i p t 5 Chitosan-based nanoparticles were applied as protein carriers since the encapsulated proteins in those nanoparticles have already been shown to be protected from the toxic solvent using sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and circular dichroism (CD) spectroscopy [1,10,31,34].…”

Effects of poly(ethylene oxide) and ZnO nanoparticles on the morphology, tensile and thermal properties of cellulose acetate nanocomposite fibrous film

“…These results suggested that the fine morphology of the electrospun fibers can be successfully created by the proper modulation of the solution properties; similar results have also been reported by other researchers. 9,17,[19][20][21][22][23][24][25] The Fourier-transform infrared spectra of the electrospun CA fibers showed a strong ester carbonyl stretching vibration at 1750 cm À1 , 26 whereas those of PEO fibers exhibited strong peaks at 2900 cm À1 that were attributed to the molecular stretching of methylene groups (CH 2 ). 9 The Fourier-transform infrared spectra of the CA-PEO fibers exhibited both of these characteristic peaks, as shown in Figure 4.…”

Core‐Sheath Fibers for Regenerative Medicine

“…Core-sheath fibers combine the two most desirable properties of tissue engineering, i.e., sustained and targeted delivery of biomolecules with template of tissue regeneration (scaffold). Recently, existing knowledge of particulate technology for drug delivery applications has been integrated with core-sheath nanofibers [66,95,96]. The encapsulation of biomolecules-loaded nanoparticles and liposomes into core-sheath fibrous scaffolds allow for the programmable delivery of multiple drugs together.…”

“…The controlled surface property and distinct release profile of a core-sheath nanofibrous device can be useful for therapeutic tissue engineering. In following years several other studies have reported multiple drug delivery systems including chitosan nanoparticles/ PCL with Rhodamine-B/naproxane model drugs in core-sheath nanofibers [94][95][96]. The implementation of core-sheath electrospun fibers for single and multiple drug deliveries demonstrated the potential of this technology.…”