Electrospun fibrous mat based on silver (I) metal-organic frameworks-polylactic acid for bacterial killing and antibiotic-free wound dressing

Zhang, Siqi; Ye, Junwei; Sun, Yuan; Kang, Jian; Liu, Jianhui; Wang, Ye; Li, Yachen; Zhang, Lihua

doi:10.1016/j.cej.2020.124523

Cited by 116 publications

(43 citation statements)

References 49 publications

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“…With the purpose of avoiding disadvantages of conventional antibiotic-loaded wound dressings, Zhang et al in their research work employed the electrospinning process to develop fibrous composite based on silver (I) metal-organic frameworks-PLA antibiotic-free wound dressing with the efficient antibacterial capability to promote tissue regeneration, simultaneously. The in vivo experiments indicated that the electrospun fibrous composite could significantly accelerate the healing rate of infected wounds in rats [10]. Fang et al employed the coaxial electrospinning method to develop core-shell nanofibers based on PLA and γ-PGA for wound healing as tissue engineering scaffolds.…”

Section: Application Of Pla-based Electrospun Fibers In Wound Healingmentioning

confidence: 99%

“…In the past decade, wound healing treatments have progressed from traditional treatments using ointments and gauze coverage to advanced multifunctional wound dressings and tissue engineered substitutes. Inexpensive and readily available conventional wound dressings such as gauze and bandages can basically protect the wound from external agents, but they create a dry environment locally, which can lead to complications, such as subsequent infections [2,10]. In recent years, considerable advances have been achieved in designing modern dressings to protect the wound from dehydration and infection, and facilitate the healing process instead of just covering the wound [3,11,12].…”

Section: Introductionmentioning

confidence: 99%

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Bio-Based Electrospun Fibers for Wound Healing

Azimi

Maleki

Zavagna

et al. 2020

JFB

163

106

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Being designated to protect other tissues, skin is the first and largest human body organ to be injured and for this reason, it is accredited with a high capacity for self-repairing. However, in the case of profound lesions or large surface loss, the natural wound healing process may be ineffective or insufficient, leading to detrimental and painful conditions that require repair adjuvants and tissue substitutes. In addition to the conventional wound care options, biodegradable polymers, both synthetic and biologic origin, are gaining increased importance for their high biocompatibility, biodegradation, and bioactive properties, such as antimicrobial, immunomodulatory, cell proliferative, and angiogenic. To create a microenvironment suitable for the healing process, a key property is the ability of a polymer to be spun into submicrometric fibers (e.g., via electrospinning), since they mimic the fibrous extracellular matrix and can support neo- tissue growth. A number of biodegradable polymers used in the biomedical sector comply with the definition of bio-based polymers (known also as biopolymers), which are recently being used in other industrial sectors for reducing the material and energy impact on the environment, as they are derived from renewable biological resources. In this review, after a description of the fundamental concepts of wound healing, with emphasis on advanced wound dressings, the recent developments of bio-based natural and synthetic electrospun structures for efficient wound healing applications are highlighted and discussed. This review aims to improve awareness on the use of bio-based polymers in medical devices.

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Section: Application Of Pla-based Electrospun Fibers In Wound Healingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Bio-Based Electrospun Fibers for Wound Healing

Azimi

Maleki

Zavagna

et al. 2020

JFB

163

106

View full text Add to dashboard Cite

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“…Interestingly, MOFs have free functional groups decorated on their surfaces, thus they provide opportunities for their surface functionalization or engineering. Surface engineered MOFs render unique properties, such as targeted delivery, stability, controlled release of their loaded contents, and additional biological properties (Ghaffar et al, 2019;Zhang S. et al, 2020). Many functional biological molecules can be chemically or physically conjugated or adsorbed on the surfaces of MOFs via surface engineering, thus leading to synergistic properties.…”

Section: Surface Engineered Mofs In Wound Healingmentioning

confidence: 99%

“…Surface engineered MOFs render unique properties, such as targeted delivery, stability, controlled release of their loaded contents, and additional biological properties (Ghaffar et al, 2019). Recently surface engineered MOFs have attracted a greater scientific interest for wound healing due to their intrinsic biological properties and delivery and controlled release of therapeutic agents (Zhang M. et al, 2020;Zhang S. et al, 2020). Moreover, the concept of surface engineered MOFs systems with or without therapeutic agents is gaining increasing popularity for quick and cost-effective wound healing (Yu et al, 2018;Ren et al, 2019;Zhang M. et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Surface Engineered Metal-Organic Frameworks (MOFs) Based Novel Hybrid Systems for Effective Wound Healing: A Review of Recent Developments

Chen

Cai

et al. 2020

Front. Bioeng. Biotechnol.

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Wounds present serious medical complications and their healing requires strategies that promote angiogenesis, deposition of collagen as well as re-epithelialization of wounds. Currently used conventional wound healing strategies have become less effective due to various issues associated with them. Thus, novel strategies are needed to be developed for early and effective healing of wounds. Metal-organic frameworks (MOFs), formed by linking of metal ions through organic bridging ligands, are highly tunable hybrid materials and have attracted more considerable scientific attention due to their charming and prominent properties, such as abundant pore structures and multiple functionalities. Surface engineering of MOFs with unique ligands can overcome issues associated with conventional wound healing methods, thus resulting in early and effective wound healing. This review has been undertaken to elaborate wound healing, and the use of surface engineered MOFs for effective and rapid wound healing. The process of wound healing will be discussed followed by a detailed review of recent literature for summarizing applications of surface engineered MOFs for wound healing. MOFs wound healing will be discussed in terms of their use as antibacterial agents, therapeutic delivery vehicles, and dressing systems in wound healing.

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“…科研人员也正是从中获得启发, 研制出了各种类型的银离子抗菌产品. Jaffres 及其同事 [46] [50] . 该复合纤维膜对 E. coli Zn 2＋是一种无毒的抗菌性阳离子, 被广泛用于皮肤科作为收敛剂、保湿剂及抗菌剂 [51,52] .…”

Section: Resistant Bacteria Modelunclassified

Research Progress of Metal-Organic Frameworks Based Antibacterial Materials

Qi¹,

Ren²,

Che³

et al. 2020

Acta Chim. Sinica

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With the accelerating process of industrialization and urbanization, as well as the increasing proportion of the elderly in the world's population, we are facing more complex health threats related to bacterial infection. While the vast majority of the bacteria in the body are rendered harmless by the protective effects of the immune system, the continued abuse and misuse of antibiotics has accelerated the spread of antibiotic-resistant bacterial strains and has resulted in substantial new challenges with respect to modern-day antibiotic-based treatments. Therefore, intelligent design of new antibacterial modalities to be used for treating human and livestock diseases is an extremely urgent priority for researchers in the fields of chemistry, chemical engineering, materials and biomedical sciences. Toward this end, the most intriguing of the new developments are metal-organic frameworks (MOFs). MOFs are versatile crystalline porous lattices of organic ligands and metal ion/clusters that formed by self-assembly via coordination bonds. Due to their unique characteristics, including relatively straight forward and simple methods for synthesis, large surface areas, novel and diverse structures, and adjustable porosity, MOFs not only play strong roles with respect to novel methods for gas storage and separation, they may also be utilized in unique applications associated with sensors mechanisms and catalysis. These features contribute to our current understanding of MOFs as promising candidates for the development of pharmaceutical and specifically antibacterial applications. In this review, antibacterial mechanisms, and the development of resistance to current antibiotic strategies are summarized and discussed. The main mechanisms by which bacteria show resistance to antibiotics include altered metabolic pathways, regulation of target sites, and inactivation, modification, and/or reduction in the capacity to accumulate antibacterial drugs. We consider recent progress on the development of MOFs, including the use of specific metal centers and ligands, metal nanoparticles, and drug-encapsulation, all of which have important applications with respect to antibacterial activities, and wound healing. Finally, the challenges and prospects of MOF-based antibacterial materials are discussed, including critical findings, which will help toward the development of the next generation antibacterial MOFs for human use.

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Electrospun fibrous mat based on silver (I) metal-organic frameworks-polylactic acid for bacterial killing and antibiotic-free wound dressing

Cited by 116 publications

References 49 publications

Bio-Based Electrospun Fibers for Wound Healing

Bio-Based Electrospun Fibers for Wound Healing

Surface Engineered Metal-Organic Frameworks (MOFs) Based Novel Hybrid Systems for Effective Wound Healing: A Review of Recent Developments

Research Progress of Metal-Organic Frameworks Based Antibacterial Materials

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