Elevated soluble tumor necrosis factor receptor levels in seasonal allergic rhinitis patients

Abstract

In this study, we examined the symptom scores and tumor necrosis factor-alpha (TNF-alpha), p55 soluble tumor necrosis factor receptor (sTNFR1), and p75 soluble tumor necrosis factor receptor (sTNFR2) levels in the sera and nasal epithelial lining fluids (ELF) of 20 patients with Japanese cedar pollinosis from the pre- to the postseason period, and compared the results with those of 10 nonallergic control subjects. The symptom scores of the allergic subjects were significantly (P<0.01) higher than those of the nonallergic subjects during the early stage and mid-stage of the season. There were no statistical differences between the allergic and nonallergic subjects in the TNF-alpha levels in sera and ELF from the pre- to the postseason. In the allergic subjects, however, the levels of sTNFR1 and sTNFR2 in ELF were significantly elevated during the early stage (P<0.05) and mid-stage (P<0.01) of the season, whereas those in sera did not change from the pre- to the post-season period. The levels of TNF-alpha in ELF were more than 10 times higher than those in sera, whereas the levels of sTNFR1 and sTNFR2 in ELF were less than half of those in sera in the allergic and nonallergic subjects. These results suggest that sTNFR1 and sTNFR2 may play a role in the pathogenesis of nasal allergic reaction.

Different serum soluble Fas levels in patients with allergic rhinitis and bronchial asthma

“…2A). These results basically corresponded to those in our previous report of the reduction of serum sFas and soluble tumor necrosis factor receptor levels in allergic rhinitis ( 8, 9). In contrast, serum sFas levels in patients with bronchial asthma during the attack phase ( n =22; 2.24±0.80 ng/ml) were higher ( P <0.0005) than those in healthy individuals ( Fig.…”

“…To our knowledge, the dynamics of allergy‐inducing cells and molecules in bronchial asthma is similar to that in allergic rhinitis ( 9–13). Clinically, these two diseases often overlap with each other, and their pathogeneses are believed to be closely related.…”

Association of TLR-4 and TNF-alpha polymorphisms with clinical symptoms and cytokine levels in patients with allergic rhinitis

“…In a multiple linear regression analysis sTNF-alpha and sFasL concentrations proved to be the most significant predictors of the patient's PNIF values and IgE concentration in the pollen season. These observations are in accordance with several earlier observations [13][14][15]. Cytokine and IgE levels, clinical score, and PNIF values were significantly different during and after the pollen season in patients with seasonal ragweed allergic rhinitis carrying the mutant alleles of the TNF-alpha promoter and the TLR-4 receptor.…”

Molecular Network Associated with MITF in Skin Melanoma Development and Progression

“…The environmental factors can be classified into physical [1–4], chemical [5–8], and biological [9, 10] factors. In addition to the environmental factors, genetic factors also have a great influence on the development and pathogenesis of various diseases [2, 11, 12].…”