Elimination of enrofloxacin in striped catfish (Pangasianodon hypophthalmus) following on-farm treatment

Phú, Trần Minh; Douny, Caroline; Scippo, Marie‐Louise; Pauw, Edwin De; Thịnh, Nguyễn Quốc; Hương, Đỗ Thị Thanh; Vinh, Huynh Phuoc; Phương, Nguyễn Thanh; Dalsgaard, Anders

doi:10.1016/j.aquaculture.2014.12.032

Cited by 34 publications

(23 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been reported that about 10% of the enrofloxacin is metabolized to ciprofloxacin on the first day of treatment in catfish. 24 Therefore, most of the detected ciprofloxacin is considered a metabolite of enrofloxacin. Trimethoprim and sulfamethazine or sulfamethoxazole are normally mixed in commercial products, 9 and they were often detected in combination.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Monitoring of Antibiotic Residues in Aquatic Products in Urban and Rural Areas of Vietnam

Uchida

Konishi

Harada

et al. 2016

J. Agric. Food Chem.

View full text Add to dashboard Cite

Antibiotic residues in aquatic products in Vietnam were investigated. A total of 511 fish and shrimp samples were collected from markets in Ho Chi Minh City (HCMC), Thai Binh (TB), and Nha Trang (NT) from July 2013 to October 2015. The samples were extracted with 2% formic acid in acetonitrile and washed with dispersive C18 sorbent. Thirty-two antibiotics were analyzed by LC-MS/MS. Of the 362 samples from HCMC, antibiotic residues were found in 53 samples. Enrofloxacin was commonly detected, at a rate of 10.8%. In contrast, samples from TB and NT were less contaminated: only 1 of 118 analyzed samples showed residues in TB and only 1 of 31 showed residues in NT. These differences were attributed to the local manufacturing/distribution systems. To understand the current status of antibiotic use and prevent adverse effects that may be caused by their overuse, continual monitoring is required.

show abstract

Section: ■ Results and Discussionmentioning

confidence: 99%

Monitoring of Antibiotic Residues in Aquatic Products in Urban and Rural Areas of Vietnam

Uchida

Konishi

Harada

et al. 2016

J. Agric. Food Chem.

View full text Add to dashboard Cite

show abstract

“…China has given permission for ENR to be used in aquaculture, and it has become an essential strategy to confront and alleviate infectious disease and reduce animal mortality. The pharmacokinetics of ENR have been reported in a number of aquatic animals, including Korean catfish (Kim, Lim, Park, Hwang, & Yun, ), seabass (Intorre et al., ), snakehead fish (Fang, Zhou, & Liu, ), striped catfish (Phu et al., ) and turbot (Liang, Li, Zhao, Liu, & Chang, ). Nevertheless, information about the pharmacokinetics of ENR in crucian carp is deficient.…”

Section: Pharmacokinetic Parameters Of Enrofloxacin and Ciprofloxacinmentioning

confidence: 99%

Pharmacokinetics of enrofloxacin after oral, intramuscular and bath administration in crucian carp (Carassius auratus gibelio)

Fan

Wang

et al. 2017

Vet Pharm & Therapeutics

View full text Add to dashboard Cite

The pharmacokinetics of enrofloxacin (ENR) was studied in crucian carp (Carassius auratus gibelio) after single administration by intramuscular (IM) injection and oral gavage (PO) at a dose of 10 mg/kg body weight and by 5 mg/L bath for 5 hr at 25°C. The plasma concentrations of ENR and ciprofloxacin (CIP) were determined by HPLC. Pharmacokinetic parameters were calculated based on mean ENR or CIP concentrations using WinNonlin 6.1 software. After IM, PO and bath administration, the maximum plasma concentration (Cmax) of 2.29, 3.24 and 0.36 μg/ml was obtained at 4.08, 0.68 and 0 hr, respectively; the elimination half‐life (T1/2β) was 80.95, 62.17 and 61.15 hr, respectively; the area under the concentration–time curve (AUC) values were 223.46, 162.72 and 14.91 μg hr/ml, respectively. CIP, an active metabolite of enrofloxacin, was detected and measured after all methods of drug administration except bath. It is possible and practical to obtain therapeutic blood concentrations of enrofloxacin in the crucian carp using IM, PO and bath immersion administration.

show abstract

“…China has given permission for ENR to be used in aquaculture, and it has become an essential strategy to confront and alleviate infectious disease and reduce animal mortality. Pharmacokinetic traits of ENR have been researched in a number of aquatic animals, including Korean catfish (Kim et al, 2006), sea bass (Intorre et al, 2000), silver crucian carp (Fang et al, 2012), snakehead fish (Fang et al, 2016), striped catfish (Phu et al, 2015), and turbot (Liang et al, 2012). Adequate information on the pharmacokinetics of ER in each species is pivotal for a successful therapeutic plan.…”

mentioning

confidence: 99%

Comparative pharmacokinetics of enrofloxacin in healthy and Aeromonas hydrophila‐infected crucian carp (Carassius auratus gibelio)

Fan

Wang

et al. 2017

Vet Pharm & Therapeutics

View full text Add to dashboard Cite

The comparative pharmacokinetics of enrofloxacin (ENR) and its metabolite ciprofloxacin (CIP) were investigated in healthy and Aeromonas hydrophila-infected crucian carp after a single oral (p.o.) administration at a dose of 10 mg/kg at 25 °C. The plasma concentrations of ENR and of CIP were determined by HPLC. Pharmacokinetic parameters were calculated based on mean ENR concentrations by noncompartmental modeling. In healthy fish, the elimination half-life (T ), maximum plasma concentration (C ), time to peak (T ), and area under the concentration-time curve (AUC) values were 64.66 h, 3.55 μg/mL, 0.5 h, and 163.04 μg·h/mL, respectively. In infected carp, by contrast, the corresponding values were 73.70 h, 2.66 μg/mL, 0.75 h, and 137.43 μg·h/mL, and the absorption and elimination of ENR were slower following oral administration. Very low levels of CIP were detected, which indicates a low extent of deethylation of ENR in crucian carp.

show abstract

Elimination of enrofloxacin in striped catfish (Pangasianodon hypophthalmus) following on-farm treatment

Cited by 34 publications

References 12 publications

Monitoring of Antibiotic Residues in Aquatic Products in Urban and Rural Areas of Vietnam

Monitoring of Antibiotic Residues in Aquatic Products in Urban and Rural Areas of Vietnam

Pharmacokinetics of enrofloxacin after oral, intramuscular and bath administration in crucian carp (Carassius auratus gibelio)

Comparative pharmacokinetics of enrofloxacin in healthy and Aeromonas hydrophila‐infected crucian carp (Carassius auratus gibelio)

Contact Info

Product

Resources

About