Ellagic Acid Prevents Cisplatin‐Induced Oxidative Stress in Liver and Heart Tissue of Rats

Yüce, Abdurrauf; Ateşşahín, Ahmet; Çeribaşı, Ali Osman; Aksakal, Mesut

doi:10.1111/j.1742-7843.2007.00129.x

Cited by 123 publications

(77 citation statements)

References 42 publications

(63 reference statements)

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“…On the other hand, the tubules and liver cells from rats in the CDDP + L-carnitine group were nearly normal in histological architecture, except for a minor desquamation of the kidney and liver epithelial cells. Similar findings were also reported by Yuce et al [44] and Tarladacalisir et al [6], demonstrating the structural changes in the kidney and liver tissues of CDDP-treated animals and its turn back by different agents.…”

Section: Discussionsupporting

confidence: 79%

Protective effect of L-carnitine against cisplatin-induced liver and kidney oxidant injury in rats

et al. 2009

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AbstractThe present study was designed to investigate the protective effects of L-carnitine (LC) on changes in the levels of lipid peroxidation and endogenous antioxidants induced by cisplatin (cis-diamminedichloroplatinum II, CDDP) in the liver and kidney tissues of rats. Twenty-four Sprague Dawley rats were equally divided into four groups of six rats each: control, cisplatin, L-carnitine, and L-carnitine plus cisplatin. The degree of protection produced by L-carnitine was evaluated by determining the level of malondialdehyde (MDA). The activity of glutathione (GSH), glutathione peroxidase (GSH-Px), glutathione S-transferase (GST), and superoxide dismutase (SOD) were estimated from liver and kidney homogenates, and the liver and kidney were histologically examined as well. L-carnitine elicited significant liver and kidney protective activity by decreasing the level of lipid peroxidation (MDA) and elevating the activity of GSH, GSHPx, GST, and SOD. Furthermore, these biochemical observations were supported by histological findings. In conclusion, the present study indicates a significant role for reactive oxygen species (ROS) and their relation to liver and kidney dysfunction, and points to the therapeutic potential of LC in CDDP-induced liver and kidney toxicity.

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Section: Discussionsupporting

confidence: 79%

Protective effect of L-carnitine against cisplatin-induced liver and kidney oxidant injury in rats

et al. 2009

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“…It was suggested that HES has positive effects on SOD, CAT and GSH-Px activities and has protective effects against oxidative stress in rat brain 76 . In another study, it has been demonstrated that EA enhanced increased tissue SOD, CAT and GSH-Px activities 77 . According to our results, it has been detected that SOD, CAT and GSH-Px activities increased in EA and HES groups compared to ischemia and I/R groups.…”

Section: Resultsmentioning

confidence: 99%

A comparative study on the antioxidant effects of hesperidin and ellagic acid against skeletal muscle ischemia/reperfusion injury

Akdemir

Gülçın

Karagöz

et al. 2016

Journal of Enzyme Inhibition and Medicinal Chemistry

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The antioxidant effects of ellagic acid (EA) and hesperidin (HES) against skeletal muscle ischemia/reperfusion injury (I/R) were performed. Hindlimb ischemia has been induced by tourniquet occlusion for 2 h on left hindlimb. At the end of ischemia, the tourniquate has been removed and initiated reperfusion for 2 h. EA (100 mg/kg) has been applied orally before ischemia/reperfusion in the EA + I/R group. HES (100 mg/kg) has been given orally in the HES + I/R group. The left gastrocnemius muscle has been harvested and stored immediately at À80 C until assessed for the levels of MDA and antioxidant enzymes activities. MDA level has statistically increased in I/R group (p50.05) compared to other groups. The muscle tissue antioxidant enzymes activities were lower than the other groups in the I/R group (p50.05). EA and HES treatments significantly reversed the damage level in I/R, also activity of tissue SOD increased in the EA + I/R and HES + I/R groups.

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“…Recent studies have shown that different natural antioxidants such as vitamin C, vitamin E, ellagic acid, nigella sativa, lycopen, caffeic acid phenethyl ester prevent cisplatin-induced toxicity. 13,28,[32][33][34][35] In this study, we investigated the effects of the natural antioxidants GSE and OOEO in cisplatin-treated rats by microscopic examination and biochemical assays.…”

Section: Discussionmentioning

confidence: 99%

Effects of Grape seed Extract and Origanum Onites Essential Oil on Cisplatin-Induced Hepatotoxicity in Rats

Çetin¹,

Arslanbaş²,

Saraymen³

et al. 2011

UHOD

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Cisplatin is a widely used anticancer drug but, it can produce undesirable effects such as hepatotoxicity even in therapeutic doses. The underlying mechanism in hepatotoxicity has been attributed to free oxygen radicals. The present study was designed to determine the possible protective effects of grape seed extract (GSE) and Origanum onites essential oil (OOEO) on liver toxicity induced by cisplatin. Ninetysix-male Wistar albino rats were divided into eight groups, twelve in each (Control, GSE, OOEO, GSE+OOEO, Cisplatin, GSE+ Cisplatin, OOEO+ Cisplatin, GSE+OOEO+ Cisplatin) and followed up for 10 days. Cisplatin and OOEO were injected intraperitoneally. GSE was administered with gavage. The histopathological examination of liver tissues was performed by light microscope. Superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) activities and malondialdehyde (MDA) levels were determined in liver tissues. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were measured in serum. Cisplatin-induced considerable hepatocyte damage under microscopic examination, and an increase in MDA levels as well as a decrease in the activities of antioxidant enzymes, including SOD, GSH-Px in liver tissues and an increase in serum ALT and AST (p< 0.001). The addition of GSE and/or OOEO significantly prevented microscopic tissue damage, reversed oxidative stress parameters and biochemical values compared to the cisplatin group (p< 0.001). In conclusion GSE and OOEO may be used in adjuvant therapy to prevent cisplatin-induced hepatotoxicity, but further studies using various doses, different time intervals, and a larger number of animals need to be carried out.Keywords: Cisplatin, Hepatotoxicity, Free Radicals, Grape, Thyme ÖZET Sisplatin, kanser tedavisinde yayg›n olarak kullan›lan fakat tedavi dozlar›nda dahi karaci¤er hasar› gibi istenmeyen yan etkilere sebep olabilen bir ilaçt›r. Sisplatinin karaci¤er dokusunda yapt›¤› hasar›n alt›nda yatan mekanizma büyük oranda serbest oksijen radikallerine ba¤l›d›r. Bu çal›flmada s›çanlarda sisplatin tedavisine ba¤l› oluflan karaci¤er hasar›nda üzüm çekirde¤i özütünün (ÜÇÖ) ve esansiyel kekik ya¤›n›n (EKY) muhtemel koruyucu etkilerinin araflt›r›lmas› amaçlanm›flt›r. Doksanalt› adet Wistar albino cinsi erkek s›çan; her biri oniki hayvandan oluflan sekiz gruba bölünerek (Kontrol, ÜÇÖ, EKY, ÜÇÖ+EKY, Sisplatin, ÜÇÖ+Sisplatin, EKY+Sisplatin, ÜÇÖ+EKY+Sisplatin), on gün süreyle takip edildi.

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Ellagic Acid Prevents Cisplatin‐Induced Oxidative Stress in Liver and Heart Tissue of Rats

Cited by 123 publications

References 42 publications

Protective effect of L-carnitine against cisplatin-induced liver and kidney oxidant injury in rats

Protective effect of L-carnitine against cisplatin-induced liver and kidney oxidant injury in rats

A comparative study on the antioxidant effects of hesperidin and ellagic acid against skeletal muscle ischemia/reperfusion injury

Effects of Grape seed Extract and Origanum Onites Essential Oil on Cisplatin-Induced Hepatotoxicity in Rats

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