Enantiomeric separation of adrenaline, noradrenaline, and isoprenaline by capillary electrophoresis using streptomycin-modified gold nanoparticles

Liu, Chunye; Zhang, Jingshu; Zhang, Xuejiao; Zhao, Lingzhi; Li, Shuang

doi:10.1007/s00604-018-2758-x

Cited by 31 publications

(23 citation statements)

References 35 publications

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“…Molecular modification of the surfaces of gold nanoparticles increases their stability and improves their physicochemical properties and functionality, which means they can be used in more biological chemical reactions to expand their application [52]. Current surface modification methods use covalent bonding [53,54], electrostatic interactions [55], or attachment of a small molecule or compound for specific recognition of the target [56].…”

Section: Functional Modification Of Gold Nanoparticlesmentioning

confidence: 99%

Application of Gold-Nanoparticle Colorimetric Sensing to Rapid Food Safety Screening

Liu

Huang

et al. 2018

Sensors

161

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Due to their unique optical properties, narrow size distributions, and good biological affinity, gold nanoparticles have been widely applied in sensing analysis, catalytic, environmental monitoring, and disease therapy. The color of a gold nanoparticle solution and its maximum characteristic absorption wavelength will change with the particle size and inter-particle spacing. These properties are often used in the detection of hazardous chemicals, such as pesticide residues, heavy metals, banned additives, and biotoxins, in food. Because the gold nanoparticles-colorimetric sensing strategy is simple, quick, and sensitive, this method has extensive applications in real-time on-site monitoring and rapid testing of food quality and safety. Herein, we review the preparation methods, functional modification, photochemical properties, and applications of gold nanoparticle sensors in rapid testing. In addition, we elaborate on the colorimetric sensing mechanisms. Finally, we discuss the advantages and disadvantages of colorimetric sensors based on gold nanoparticles, and directions for future development.

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Section: Functional Modification Of Gold Nanoparticlesmentioning

confidence: 99%

Application of Gold-Nanoparticle Colorimetric Sensing to Rapid Food Safety Screening

Liu

Huang

et al. 2018

Sensors

161

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“…The surface‐assembly monolayer (SAM) of gold–sulfur bond creates a strong and stable linkage for the gold materials and the surface‐modified moieties such as polymers, proteins, and antibodies. The thiol–gold bond manufacturing approach for AuNP has been used in many studies 55,70,72 …”

Section: Enantiomeric Recognition By Chiral Nanoparticlesmentioning

confidence: 99%

Application of nanoparticles in chiral analysis and chiral separation

et al. 2021

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Chiral molecules in relation to particular biological roles are stereoselective. Enantiomers differ significantly in their biochemical responses in biological environment. Despite the current advancement in drug discovery and pharmaceutical biotechnology, the chiral separation of some racemic mixtures continues to be one of the greatest challenges, because the available techniques are too costly and time consuming for the assessment of therapeutic drugs in the early stages of development worldwide. Various nanoparticles became one of the most investigated and explored nanotechnology‐derived nanostructures especially in chirality where several studies are reported to improve enantiomeric separation of different racemic mixtures. The production of surface‐modified nanoparticles has contributed to these limitations in terms of sensitivity, accuracy, and enantioselectivity that can be optimized and therefore makes these surface‐modified nanoparticles convenient for enantiomeric identification and separation.

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“…It was observed that, as compared to monolayer AuNPs film capillary column, the three layer AuNPs film capillary column possess superior enantioseparation performance. Further, in 2018, Liu et al [86] successfully added streptomycin-modified AuNPs in background electrolyte (BGE) solution in CE for the first time to separate a number of drug racemates, such as, adrenaline hydrochloride, noradrenaline bitartrate, and isoprenaline hydrochloride.…”

Section: Enantiomeric Separation By Chiral Nanoparticlesmentioning

confidence: 99%

Enantiomeric Recognition and Separation by Chiral Nanoparticles

et al. 2019

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Chiral molecules are stereoselective with regard to specific biological functions. Enantiomers differ considerably in their physiological reactions with the human body. Safeguarding the quality and safety of drugs requires an efficient analytical platform by which to selectively probe chiral compounds to ensure the extraction of single enantiomers. Asymmetric synthesis is a mature approach to the production of single enantiomers; however, it is poorly suited to mass production and allows for only specific enantioselective reactions. Furthermore, it is too expensive and time-consuming for the evaluation of therapeutic drugs in the early stages of development. These limitations have prompted the development of surface-modified nanoparticles using amino acids, chiral organic ligands, or functional groups as chiral selectors applicable to a racemic mixture of chiral molecules. The fact that these combinations can be optimized in terms of sensitivity, specificity, and enantioselectivity makes them ideal for enantiomeric recognition and separation. In chiral resolution, molecules bond selectively to particle surfaces according to homochiral interactions, whereupon an enantiopure compound is extracted from the solution through a simple filtration process. In this review article, we discuss the fabrication of chiral nanoparticles and look at the ways their distinctive surface properties have been adopted in enantiomeric recognition and separation.

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Enantiomeric separation of adrenaline, noradrenaline, and isoprenaline by capillary electrophoresis using streptomycin-modified gold nanoparticles

Cited by 31 publications

References 35 publications

Application of Gold-Nanoparticle Colorimetric Sensing to Rapid Food Safety Screening

Application of Gold-Nanoparticle Colorimetric Sensing to Rapid Food Safety Screening

Application of nanoparticles in chiral analysis and chiral separation

Enantiomeric Recognition and Separation by Chiral Nanoparticles

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