Encefalitis subaguda por anticuerpos anti receptor de N-metil-D-aspartato. Serie de 13 casos pediátricos

Erazo, Ricardo; González, Jaime; Quintanilla, Consuelo; Devaud, Claudia; Gayoso, Consuelo; Toledo, Ximena; Rauch, Erna; Riffo, Claudia; Álvarez, Carolina; Salazar, Marne; Salvo, Daniela; Dalmau, Josep; Carmona, Orietta

doi:10.1016/j.rchipe.2016.06.006

Cited by 4 publications

(4 citation statements)

References 22 publications

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“…Memory loss, as well as central hypoventilation, is observed more frequently in adults, while motor dysfunctions and ataxia predominate in children. Within the first month, most cases progress to a similar spectrum of manifestations regardless of age [11, 36, 59]. …”

Section: Clinical Manifestationsmentioning

confidence: 99%

Anti-N-Methyl-D-aspartate Receptor Encephalitis: A Severe, Potentially Reversible Autoimmune Encephalitis

Liu

Zhu

Zheng

et al. 2017

Mediators of Inflammation

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Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is potentially lethal, but it is also a treatable autoimmune disorder characterized by prominent psychiatric and neurologic symptoms. It is often accompanied with teratoma or other neoplasm, especially in female patients. Anti-NMDAR antibodies in cerebrospinal fluid (CSF) and serum are characteristic features of the disease, thereby suggesting a pathogenic role in the disease. Here, we summarize recent studies that have clearly documented that both clinical manifestations and the antibodies may contribute to early diagnosis and multidisciplinary care. The clinical course of the disorder is reversible and the relapse could occur in some patients. Anti-NMDAR encephalitis coexisting with demyelinating disorders makes the diagnosis more complex; thus, clinicians should be aware of the overlapping diseases.

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Section: Clinical Manifestationsmentioning

confidence: 99%

Anti-N-Methyl-D-aspartate Receptor Encephalitis: A Severe, Potentially Reversible Autoimmune Encephalitis

Liu

Zhu

Zheng

et al. 2017

Mediators of Inflammation

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“…La epidemiologia de la enfermedad no está bien establecida en la población pediátrica. En un estudio previo realizado Erazo et al 8 , se reportó un predominio en pacientes de género masculino, con una edad de 1 a 16 años. En el caso de nuestra serie de casos encontramos también un leve predominio en el género masculino, con un rango de edad de 2 a 15 años.…”

Section: Tratamientounclassified

Autoimmune encephalitis due to antibodies against N-methyl-D-aspartate (NMDA) receptor N-methyl-D-aspartate (NMDA) receptor: Case series in children

Martínez

Zurita

Vera

et al. 2022

Rev. parag. reumatol

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Fecha de envío 15/04/22 Fecha de aprobación 10/05/22 Palabras claves Encefalitis autoinmune; anticuerpos anti-NMDA, niños, pediátricos ResumenSe describe una serie de casos de pacientes pediátricos, con encefalitis autoinmune (EA) por anticuerpos contra el receptor N-metil-D-aspartato (NMDA), atendidos en hospitales de tercer nivel en México y Paraguay, y su evolución con inmunoterapia. Los síntomas predominantes fueron fiebre, trastornos del sueño, alucinaciones, discinesias, movimientos coreo-atetósicos, espasticidad, convulsiones y disautonomías. Los pacientes fueron tratados con inmunoglobulina humana y metilprednisolona como primera línea, y en algunos casos se requirió el uso de plasmaféresis y anti-CD20. El inicio oportuno de tratamiento se relacionó con una menor estancia hospitalaria y menor desarrollo de complicaciones. Se debe enfatizar el diagnóstico oportuno, implementando su identificación a partir del cuadro clínico, sustentando el diagnóstico con pruebas serológicas adecuadas y hallazgos en LCR, y de este modo favorecer el inicio de tratamiento temprano para reducir complicaciones y días de internación.Autoimmune encephalitis due to antibodies against n-methyl-D-aspartate (nmDA) receptor n-methyl-D-aspartate (nmDA) receptor: Case series in children

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“…Sixteen were diagnosed with ovarian teratoma (6.35%), one was diagnosed with serous ovarian cystadenoma (0.4%), one was diagnosed with papillary thyroid carcinoma (0.4%), and one was diagnosed with a complex ovarian cyst (0.4%), all female. Cases associated with known triggers were due to Epstein-Barr virus infection (1 case in Brazil), chikungunya virus infection (1 case in Brazil), mycoplasma infection (5 cases in Argentina), human herpes virus 7 infection (5 cases in Mexico), human herpes virus 6 infection (1 case in Mexico), and Varicella-zoster infection (1 case in Costa Rica and 2 cases in Chile) (7)(8)(9)(10)(11)(12). Transfer to Intensive Care Unit (ICU) was reported in only 9.35% of patients (N = 33).…”

Section: Anti-nmda Receptor Encephalitismentioning

confidence: 99%

Autoimmune Encephalitis in Latin America: A Critical Review

et al. 2021

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Autoimmune encephalitis is an increasingly recognized cause of encephalitis. The majority of case series report patients residing in developed countries in the northern hemisphere. The epidemiologic features of autoimmune encephalitis in Latin America are still unclear. The aim of the study was to perform a review of the clinical presentation of autoimmune encephalitis in Latin America and compare to world literature. References were identified by an in-depth literature search and selected on the basis of relevance to the topic and authors' judgment. We selected clinical studies and case reports published from 2007 to July, 2020 including patients from Latin American countries. Of the 379 patients included, the majority were cases of anti-NMDA receptor encephalitis (93.14%), followed by anti-VGKC-complex encephalitis (N = 17; 4.48%), anti-GAD encephalitis (N = 9; 2.37%), anti-AMPA receptor encephalitis (N = 1; 0.26%), anti-GABA receptor encephalitis (N = 1; 0. 26%), anti-mGluR5 encephalitis (N = 1; 0. 26%), and anti-mGluR1 encephalitis (N = 1; 0. 26%). Reported cases of Anti-NMDA encephalitis in Latin-America had a very slight female predominance, lower prevalence of associated tumors and a lower incidence of extreme delta brush on electroencephalogram. Autoimmune encephalitis is possibly underdiagnosed in underdeveloped countries. Its outcome after treatment, however, appears to be similarly favorable in Latin American patients as has been reported in developed countries based on available case reports and case series. Regional specificities in the manifestation of autoimmune encephalitis could be related to epidemiologic factors, such as the presence of different triggers and different genetic and immunologic background, that need to be studied by future research.

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Encefalitis subaguda por anticuerpos anti receptor de N-metil-D-aspartato. Serie de 13 casos pediátricos

Cited by 4 publications

References 22 publications

Anti-N-Methyl-D-aspartate Receptor Encephalitis: A Severe, Potentially Reversible Autoimmune Encephalitis

Anti-N-Methyl-D-aspartate Receptor Encephalitis: A Severe, Potentially Reversible Autoimmune Encephalitis

Autoimmune encephalitis due to antibodies against N-methyl-D-aspartate (NMDA) receptor N-methyl-D-aspartate (NMDA) receptor: Case series in children

Autoimmune Encephalitis in Latin America: A Critical Review

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