Endoscopic and bioptic study of the upper gastrointestinal tract in crohn’s disease patients

Schmitz-Moormann, P; Malchow, H; Pittner, P.M.

doi:10.1016/s0344-0338(85)80147-3

Cited by 115 publications

(54 citation statements)

References 9 publications

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“…Estes são encontrados em 7% a 22% dos casos (7,19) , havendo relatos mais recentes de 68% (31) a 83% (36) em trabalhos onde maior número de fragmentos (21) e de cortes seriados (70 por bloco) foi utilizado. Empregando esta mesma metodologia, ALCÁNTARA et al (1) encontraram granulomas em apenas 19,5%, o que poderia ser explicado, segundo os autores, pela menor idade dos pacientes estudados e menor proporção de lesões endoscópicas, situações em que a incidência de granulomas é menor (1,33) . Outros achados sugestivos de DC são linfangiectasias e folículos linfóides na profundidade da mucosa, inflamação transmural, abscesso de criptas, displasia epitelial e fibrose mucosa e submucosa combinadas (39) .…”

Section: Discussionunclassified

See 1 more Smart Citation

Doença de Crohn gastroduodenal -- relato de quatro casos e revisão da literatura

Abrahão

Vargas

Chagas

et al. 2001

Arq. Gastroenterol.

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Section: Discussionunclassified

“…Mais recentemente, estudos prospectivos incluindo pacientes sintomáticos e assintomáticos, têm reportado incidência de 17% a 75% de envolvimento gastroduodenal (1,19,33) .…”

unclassified

Doença de Crohn gastroduodenal -- relato de quatro casos e revisão da literatura

Abrahão

Vargas

Chagas

et al. 2001

Arq. Gastroenterol.

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“…The combined frequency of gastric body lesions is reported to be 34-45%. The gastric lesions included mucosal edema, mucosal redness and granular mucosa [11,15], and the 'gastric lesions' were thought to contain non-specific findings related to gastritis. Thus, the sensitivity of these findings is thought to be low in CD patients.…”

Section: Gastric Lesionsmentioning

confidence: 99%

“…Since the 1980s, endoscopic technology and diagnostic accuracy have improved and upper GIT lesions can be detected by EGD; thus, numerous reports have been published on the diagnostic imaging of upper gastrointestinal lesions. The results have revealed that the frequency of upper GIT lesions in CD patients was never low (30-75%) ( Table 1) [9][10][11][12][13][14][15][16][17]. The present review describes the typical findings, which are useful for the diagnosis of CD, in each part of the upper GIT.…”

Section: Introductionmentioning

confidence: 96%

The endoscopic findings of the upper gastrointestinal tract in patients with Crohn’s disease

Nomura

Moriichi

Fujiya

et al. 2017

Clin J Gastroenterol

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Crohn's disease (CD) is a type of chronic inflammatory bowel disease (IBD) associated with ulceration, and the main foci of the inflammation in CD patients are typically the terminal ileum and colon. However, in the upper gastrointestinal tract (GIT), including the esophagus, stomach and duodenum, inflammatory lesions are also detected as well, with a relatively high frequency (30-75%). Recent advances in imaging modalities, including endoscopy, have aided in the diagnosis of CD. Various lesions, including aphtha, erosion, ulcers, bamboojoint-like appearance and notch-like appearance, are detected in the upper GI of CD patients. Of these lesions, the bamboo-joint-like appearance in the gastric cardiac region and notch-like appearance in the second portion of the duodenum are highly specific for CD, regardless of the disease activity at other sites. These two findings, particularly a bamboo-joint-like appearance, have therefore been considered as potential biomarkers for CD. Although proton pump inhibitors (PPIs) are administered as an initial treatment for upper GIT lesions of CD, the efficacy of this treatment remains controversial. The administration of mesalazine, steroids, immunosuppressant and biologic agents is expected to be effective for treating such lesions.

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“…Histologically, Crohn's disease lesions are typically encountered as granulomas and multinucleated giant cells in surgical specimens (Haggitt and Meissner, 1973) or biopsy samples taken at the time of upper gastrointestinal endoscopy (Schmitz- Moormann et al, 1985;Korelitz et al, 1981). Focally enhanced gastritis is more often detected on biopsies of the upper gastrointestinal tract in patients with Crohn's disease or ulcerative colitis than H. pylori-related gastritis (Sharif et al, 2002).…”

Section: Prevalence Of Helicobacter Pylori Infection In Ibdmentioning

confidence: 99%

Abnormalities in the upper gastrointestinal tract in inflammatory bowel disease

et al. 2007

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The predominant histopathologic feature of inflammatory bowel disease is the infiltration of acute and chronic inflammatory cells, including polymorphonuclear neutrophils, macrophages and lymphocytes, in the affected intestine. Helicobacter pylori is recognized as the most common cause of upper gastrointestinal lesions, and Helicobacter pylori-associated gastritis is characterized by increased numbers of acute and chronic inflammatory cells. The pathogenesis of inflammatory bowel disease or Helicobacter pylori-associated gastritis involves immunological abnormalities, including the deficient or excessive expression of cytokines. The chronic inflammatory process in patients with Crohn's disease may affect any part of the gastrointestinal tract, whereas ulcerative colitis affects mainly the colon and rectum. Here, we discuss abnormalities in the upper gastrointestinal tract in inflammatory bowel disease. Although the prevalence rate of Helicobacter pylori infection is low in Crohn's disease, these patients often have abnormalities in the upper gastrointestinal tract.

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Endoscopic and bioptic study of the upper gastrointestinal tract in crohn’s disease patients

Cited by 115 publications

References 9 publications

Doença de Crohn gastroduodenal -- relato de quatro casos e revisão da literatura

Doença de Crohn gastroduodenal -- relato de quatro casos e revisão da literatura

The endoscopic findings of the upper gastrointestinal tract in patients with Crohn’s disease

Abnormalities in the upper gastrointestinal tract in inflammatory bowel disease

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