Enhanced mechanical strength and sustained drug release of gelatin/keratin scaffolds

Ramadoss, P.; Arul, K. Thanigai; Ramya, J. Ramana; Begam, M. Rigana; Manikandan, E.

doi:10.1016/j.matlet.2016.09.095

Cited by 23 publications

(9 citation statements)

References 18 publications

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“…%) and gelatine/Bombyx mori silk (88/12 wt. %) also made it possible to obtain hemocompatible three-dimensional scaffolds with highly interconnected pores, via the freeze-drying technique, as described by Arul et al The gelatine/keratin composite presented higher porosity (366 ± 49 µm), a better mechanical strength (about 0.23 MPa) and sustained a more controlled drug release (sodium diclofenac), in comparison to the gelatine/silk composite [303].…”

Section: Collagen and Gelatinementioning

confidence: 99%

Keratin Associations with Synthetic, Biosynthetic and Natural Polymers: An Extensive Review

Donato

Mija

2019

Polymers

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Among the biopolymers from animal sources, keratin is one the most abundant, with a major contribution from side stream products from cattle, ovine and poultry industry, offering many opportunities to produce cost-effective and sustainable advanced materials. Although many reviews have discussed the application of keratin in polymer-based biomaterials, little attention has been paid to its potential in association with other polymer matrices. Thus, herein, we present an extensive literature review summarizing keratin’s compatibility with other synthetic, biosynthetic and natural polymers, and its effect on the materials’ final properties in a myriad of applications. First, we revise the historical context of keratin use, describe its structure, chemical toolset and methods of extraction, overview and differentiate keratins obtained from different sources, highlight the main areas where keratin associations have been applied, and describe the possibilities offered by its chemical toolset. Finally, we contextualize keratin’s potential for addressing current issues in materials sciences, focusing on the effect of keratin when associated to other polymers’ matrices from biomedical to engineering applications, and beyond.

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Section: Collagen and Gelatinementioning

confidence: 99%

Keratin Associations with Synthetic, Biosynthetic and Natural Polymers: An Extensive Review

Donato

Mija

2019

Polymers

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“…Different from the other proteins, it contains quite high cysteine content (5-10 mol%) that promotes its mechanical, chemical and thermal stability features due to the disulfide bonds present in their structures [19][20][21]. Like the other biopolymers from biological origins such as collagen, elastin and chitosan, keratin alone and mixed with other polymers have been also tested in various biomedical applications such as delivery of bioactive agents [22][23][24], wound healing [17,[25][26][27], and bone tissue engineering [28][29][30]. It has been almost genuinely proven that keratins are promising candidates as sustainable biomaterials due to their abundance, low cost and biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

Self-assembly behavior of the keratose proteins extracted from oxidized Ovis aries wool fibers

Pakkaner

Yalçın

Uysal

et al. 2019

International Journal of Biological Macromolecules

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Water soluble keratose proteins were obtained from an Ovis Aries wool using peracetic acid oxidation. The wool samples and the extracted keratose proteins were characterized by using FTIR, XRD, SEM and TGA techniques. Fractions of α-keratose (MW = 43-53 kDa) along with protein species with molecular weights between 23 kDa and 33 kDa were identified in the SDS-PAGE analysis result of the extracted protein mixture. DLS and AFM experiments indicated that self-assembled globular nanoparticles with diameters between 15 nm and 100 nm formed at 5 mg/ml keratose concentration. On the other hand, upon incubation of 10 w % keratose solutions at 37 °C and 50 °C, interconnected keratose hydrogels with respective storage modulus (G') values of 0.17 ± 0.03 kPa and 3.7 ± 0.5 kPa were obtained. It was shown that the keratose hydrogel prepared at 37 °C supported L929 mouse fibroblast cell proliferation which suggested that these keratose hydrogels could be promising candidates in soft tissue engineering applications.

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“…The O. D values at 545 nm for both the samples were then substituted in the following formula [32] for calculating the percentage of hemolysis that has occurred when in contact…”

Section: Hemolysismentioning

confidence: 99%

Drug Eluting Bioresorbable Cellulose Acetate/PEO/HPMC Composite With Propolis Extracts for Suturing Application

Ramadoss¹,

Arivuoli²,

Basha³

2021

JMSSE

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A detailed study on a drug eluting cellulose based resorbable suture material, elaborately characterized for its mechanical and physico-chemical properties is presented. The biocompatibility of the material was tested with 3T3 [NIH] cells. The material's ability to be heat sterilized has been verified with thermogravimetric analysis which exhibited stability up to 200°C. Drug eluting property of the material loaded with propolis and without propolis has been assessed and the corresponding kinetics was determined. The material with propolis has shown a sustained drug release property of up to 56.96% in 72 hours following Zero-order kinetics. For an ideal suture material, blood clotting on the surface of the material could lead to serious complications, the synthesized cellulose composite materials have shown anti-thrombogenic property. The cellulose composite material with propolis incorporation has shown superior properties in mechanical strength, thermal stability, drug release, biocompatibility, surface wettability, anti-microbial and thrombus formation characteristics which is ideal for suture application. The composite material showed favorable morphological and mechanical changes during various stages of in-vitro degradation in DMEM.

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Enhanced mechanical strength and sustained drug release of gelatin/keratin scaffolds

Cited by 23 publications

References 18 publications

Keratin Associations with Synthetic, Biosynthetic and Natural Polymers: An Extensive Review

Keratin Associations with Synthetic, Biosynthetic and Natural Polymers: An Extensive Review

Self-assembly behavior of the keratose proteins extracted from oxidized Ovis aries wool fibers

Drug Eluting Bioresorbable Cellulose Acetate/PEO/HPMC Composite With Propolis Extracts for Suturing Application

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