Enhanced VEGF Expression in Hair Follicle Dermal Papilla Cells by Centella asiatica Linn.

Saansoomchai, Pahol; Limmongkon, Apinun; Surangkul, Damratsamon; Chewonarin, Teera; Srikummool, Metawee

doi:10.12982/cmujns.2018.0003

Cited by 11 publications

(17 citation statements)

References 30 publications

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“…The research on herbs and active constituents as hair growth promoters has been driven by their less toxicity, easy availability, low‐cost, patient compliance and more than one mode of biochemical action . Specific effects of herbal extracts, polyherbal formulations, flavonoids and natural compounds on DPCs have been examined . In vivo hair growth promoting effects as proof of concept are also mentioned.…”

Section: Hair Growth Promoting Effectmentioning

confidence: 99%

Review of Hair Follicle Dermal Papilla cells asin vitroscreening model for hair growth

Madaan

Verma

Singh

et al. 2018

Intern J of Cosmetic Sci

125

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Hair disorders such as hair loss (alopecia) and androgen dependent, excessive hair growth (hirsutism, hypertrichosis) may impact the social and psychological well-being of an individual. Recent advances in understanding the biology of hair have accelerated the research and development of novel therapeutic and cosmetic hair growth agents. Preclinical models aid in dermocosmetic efficacy testing and claim substantiation of hair growth modulators. The in vitro models to investigate hair growth utilize the hair follicle Dermal Papilla cells (DPCs), specialized mesenchymal cells located at the base of hair follicle that play essential roles in hair follicular morphogenesis and postnatal hair growth cycles. In this review, we have compiled and discussed the extensively reported literature citing DPCs as in vitro model to study hair growth promoting and inhibitory effects. A variety of agents such as herbal and natural extracts, growth factors and cytokines, platelet-rich plasma, placental extract, stem cells and conditioned medium, peptides, hormones, lipid-nanocarrier, light, electrical and electromagnetic field stimulation, androgens and their analogs, stress-serum and chemotherapeutic agents etc. have been examined for their hair growth modulating effects in DPCs. Effects on DPCs' activity were determined from untreated (basal) or stress induced levels. Cell proliferation, apoptosis and secretion of growth factors were included as primary end-point markers. Effects on a wide range of biomolecules and mechanistic pathways that play key role in the biology of hair growth were also investigated. This consolidated and comprehensive review summarizes the up-to-date information and understanding regarding DPCs based screening models for hair growth and may be helpful for researchers to select the appropriate assay system and biomarkers. This review highlights the pivotal role of DPCs in the forefront of hair research as screening platforms by providing insights into mechanistic action at cellular level, which may further direct the development of novel hair growth modulators.

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Section: Hair Growth Promoting Effectmentioning

confidence: 99%

Review of Hair Follicle Dermal Papilla cells asin vitroscreening model for hair growth

Madaan

Verma

Singh

et al. 2018

Intern J of Cosmetic Sci

125

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“…Melientha extract has been reported to possess various bioactive compounds such as terpenes, flavonoids and polyphenols, which are related to its potent antioxidative activities (Charoenchai et al, 2015). This active fraction has been linked to the solvent polarity that can extract different fractions of polar/nonpolar constituents out of the plant (Saansoomchai et al, 2018). The Moringa oleifera extracts that found in this area also showed the antioxidant activities (Fitriana et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

“…The free radical scavenging activities of Melientha ethanol extract and fractions were measured by two methods. The DPPH inhibition assay and the ABTS inhibition assay was performed and slightly modified as described by previous studies (Abramovič et al, 2018;Saansoomchai et al, 2018). With treatments of various concentrations of the ethanol extract and fractions, the decrease in absorbance was measured at 517 nm for the DPPH assay and 735 nm for the ABTS assay and the IC50 values were also reported.…”

Section: Evaluation Of Antioxidant Activities From Crude Extractmentioning

confidence: 99%

“…Total phenolic content (TP) and total flavonoid content (TF) were determined using the Folin-Ciocalteu assay and aluminium chloride colorimetric assay, respectively, as was described by previous studies with minor modifications (Saansoomchai et al, 2018). Quantification was expressed as milligram gallic acid equivalent per gram extract (mg GE/g) for TP and milligram catechin equivalent per gram extract (mg CE/g) for TF.…”

Section: Determination Of Total Phenolic and Total Flavonoid Contents From Crude Extractmentioning

confidence: 99%

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Melientha suavis Pierre. Extract: Antioxidant and Sunscreen Properties for Future Cosmetic Development

Sansomchai¹,

Jumpatong²,

Lapinee³

et al. 2020

CMUJNS

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The ultimate aim of this study was to evaluate antioxidant activities using DPPH and ABTS assay and antioxidant substances of Melientha suavis Pierre (Melientha) extracts with ethanol (EtOH) and subsequent partition with hexane, dichloromethane (CH2Cl2), ethyl acetate (EtOAc) and distilled water (W). The Melientha extract was assessed the sunscreen activities by sun protection factor which was compared with octyldimethyl PABA. Additionally, the stability test of Melientha extracts added in the cosmetic base-formula was investigated. The sun protection substances of Melientha extracts were determined by GC-MS analysis. Among the extract and fractions, the ethanolic extract showed the highest activities. The IC50 of Melientha extract to free radical scavenging determined by DPPH assay and ABTS assay were 53.20 ± 7.37 μg/ml and 64.17 ± 5.76 μg/ml, respectively. The total phenolic compound of ethanol extract was 149.87 ± 2.72 mg GE/g of ext and total flavonoid content was 51.60 ± 4.12 mg CE/g of ext. The sun protection factor (SPF) of ethanol extract was 26.61 ± 0.10. Cinamate and its derivative which were claim as sunscreen substance was found by GC-MS analysis of Melientha ethanol extract.

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“…Red jasmine rice extract has been reported to possess various bioactive compounds such as flavonoids and polyphenols, related to its potent anti-oxidative activities 3,6 . The active W extracts has been linked to the solvent polarity that can extract different fractions of polar/nonpolar constituents out of the plant 13 . The polysaccharides extract from rice brans found in this area also showed the anti-oxidant and antimicrobial activities 3 .…”

Section: Red Jasmine Rice Crude Extracts Against Abts and Dpph Radicals And Their Total Phenolic (Tp) And Total Flavonoid (Tf) Contentsmentioning

confidence: 99%

Biological activity and its related compounds of Red Jasmine rice extracts linked to normal fibroblast viability for cosmetic product

Tikapunya¹,

Pompimon²,

Khamjainuk³

et al. 2022

10.5267/j.ccl

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Red jasmine rice is recognized as a healthy food with high phenolic compounds. These compounds present antibacterial and anti-free radical properties. Moreover, colored rice exhibits a biological activity against anticancer. Objectives of this study are 1) exploring a biological screening and cell viability of 70% ethanol and aqueous extracts of red jasmine rice, 2) investigating cytotoxicity to fibroblast NIH3T3 (IC80) that is one hundred cells were found cell viability 80 cells. Red jasmine rice extracts were dried and transformed into a powder using the freeze-drying method. The extracts were treated with fibroblast NIH3T3 for MTT. The highest of IC50 of red jasmine rice extract to scavenge the DPPH and ABTS radicals was found in ethanol extract (53.20±7.37 and 64.17±5.76, respectively). The experiment showed that the ethanol and aqueous extract of red rice did not show cytotoxicity to fibroblast NIH3T3 (IC80). The extracts of red rice show the biological screening of anti-oxidation with total phenolic compounds and flavonoid contents. Moreover, it does not modify the physical properties of the cream formula. It can be concluded that the red rice extract is highly promising for the value addition.

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Enhanced VEGF Expression in Hair Follicle Dermal Papilla Cells by Centella asiatica Linn.

Cited by 11 publications

References 30 publications

Review of Hair Follicle Dermal Papilla cells asin vitroscreening model for hair growth

Review of Hair Follicle Dermal Papilla cells asin vitroscreening model for hair growth

Melientha suavis Pierre. Extract: Antioxidant and Sunscreen Properties for Future Cosmetic Development

Biological activity and its related compounds of Red Jasmine rice extracts linked to normal fibroblast viability for cosmetic product

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