Enriched protein diet-modified ghrelin expression and secretion in rats

Vallejo‐Cremades, María Teresa; Gómez-García, Lourdes; Chacatas-Cortesao, M; Moreno, Cláudia; Sanchez, Miguel; Miguel, Enrique de; Segura, Ignacio A. Gómez de

doi:10.1016/j.regpep.2004.04.016

Cited by 26 publications

(20 citation statements)

References 48 publications

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“…Ghrelin, which is largely produced by stomach cells under fasting (Sanchez et al, 2004a,b; Vallejo-Cremades et al, 2004), promotes food intake and decreases energy expenditure (Ueno et al, 2005) by acting on the growth hormone secretagogue receptor type 1A (GHS-R) (Kim et al, 2003; Egecioglu et al, 2006; Bresciani et al, 2008). The physiological role of ghrelin in the energy homeostasis is supported by investigations performed in mice revealing that genetic disruption of Ghrelin or Ghs-r can prevent high-fat induced obesity (Lee et al, 2016).…”

Section: Autonomic Regulation Of Energy Homeostasismentioning

confidence: 99%

Emerging Signaling Pathway in Arcuate Feeding-Related Neurons: Role of the Acbd7

Lanfray

Richard

2017

Front. Neurosci.

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The understanding of the mechanisms whereby energy balance is regulated is essential to the unraveling of the pathophysiology of obesity. In the last three decades, focus was put on the metabolic role played by the hypothalamic neurons expressing proopiomelanocortin (POMC) and cocaine and amphetamine regulated transcript (CART) and the neurons co-localizing agouti-related peptide (AgRP), neuropeptide Y (NPY), and gamma-aminobutyric acid (GABA). These neurons are part of the leptin-melanocortin pathway, whose role is key in energy balance regulation. More recently, the metabolic involvement of further hypothalamic uncharacterized neuron populations has been suggested. In this review, we discuss the potential homeostatic implication of hypothalamic GABAergic neurons that produce Acyl-Coa-binding domain containing protein 7 (ACBD7), precursor of the nonadecaneuropeptide (NDN), which has recently been characterized as a potent anorexigenic neuropeptide capable of relaying the leptin anorectic/thermogenic effect via the melanocortin system.

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Section: Autonomic Regulation Of Energy Homeostasismentioning

confidence: 99%

Emerging Signaling Pathway in Arcuate Feeding-Related Neurons: Role of the Acbd7

Lanfray

Richard

2017

Front. Neurosci.

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“…A study by Gomez et al showed that a single administration of intact protein, protein digest, dextrose or fat to fasted rats decreased ghrelin secretion in a similar manner [329], suggesting that the different macronutrients are equally efficient. However, Vallejo-Cremades et al reported that ghrelin plasma levels recovered faster with a highcarbohydrate and a high-fat diet than by a highprotein diet [330]. Sanchez et al, on the other hand, showed that ghrelin levels recovered faster when the rats were fed a high-fat diet compared with a high-carbohydrate diet [331].…”

Section: Ghrelinmentioning

confidence: 99%

“…Compared with standard laboratory chow or a diet enriched in carbohydrates, a high-fat diet is reported to reduce the levels of ghrelin [332][333][334]. Conversely, high-protein feeding is reported to increase ghrelin plasma levels [330]. In theory, macronutrients may influence food intake and body-weight gain by affecting circulating ghrelin levels.…”

Section: Ghrelinmentioning

confidence: 99%

“…[315,[328][329][330][331] Cholecystokinin -↑ ↑↑ Unclear [360][361][362][363][364] PYY (↑) ↑ ↑ ↑ Reduces energy efficiency, increases oxidation of fatty acids [210,378,379,436] Incretins ↑↑ ↑ (↑) Reduces glucose utilization [388,[390][391][392][393]395] Future Lipidol. (2008) 3(1) future science group future science group…”

Section: Financial and Competing Interests Disclosurementioning

confidence: 99%

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Macronutrients and obesity: views, news and reviews

Madsen¹,

Liaset²,

Kristiansen³

2008

Future Lipidology

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Profound changes in macronutrient composition of food have taken place since the agricultural revolution, leading to a higher dietary intake of carbohydrates at the expense of protein, and a dramatically increased intake of n-6 polyunsaturated fatty acids (PUFAs) at the expense of n-3 PUFAs. This review focuses on how macronutrients impact on molecular processes central to appetite regulation and energy homeostasis. We discuss the effects on transcription factors, implicated as key players in adipocyte differentiation and function, including PPARs, sterol regulatory element binding proteins and liver X receptors. Furthermore, as energy homeostasis is to a large extent orchestrated by the gut-brain axis, we discuss key hormones involved in the regulation of energy balance and appetite.

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“…carbohydrate, fat, and protein in the diet) (Erdmann et al 2003, Monteleone et al 2003, Erdmann et al 2004, Greenman et al 2004 as well as the nutritional status of ruminants and monogastric animals. Interestingly, ingestion of a high-protein (HP) diet has been shown to increase plasma ghrelin levels in sheep, humans, and rats (Erdmann et al 2003, VallejoCremades et al 2004, Takahashi et al 2012 and ghrelin synthesis in rats (Vallejo-Cremades et al 2004), even though a HP diet decreases GH secretion in wethers (Takahashi et al 2012), suppresses food intake in humans and rodents (Paddon-Jones et al 2008, Journel et al 2012, enhances satiation more than a carbohydrate or fat diet does in humans (Westerterp-Plantenga et al 1999), and induces complex signals including neuropeptides and metabolic hormones secreted from the gut in response to nutrients, blood amino acids, and metabolites (Journel et al 2012). Thus, the effects of elevations of ghrelin levels following ingestion of a HP diet are highly controversial and the detailed mechanism by which the protein diet stimulates ghrelin secretion is unclear.…”

Section: Introductionmentioning

confidence: 99%

Increased plasma ghrelin suppresses insulin release in wethers fed with a high-protein diet

Takahashi

Sato

Kato

et al. 2014

Journal of Endocrinology

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Ghrelin is a multifunctional peptide that promotes an increase of food intake and stimulates GH secretion. Ghrelin secretion is regulated by nutritional status and nutrients. Although a high-protein (HP) diet increases plasma ghrelin secretion in mammals, the mechanisms and the roles of the elevated ghrelin concentrations due to a HP diet have not been fully established. To clarify the roles of elevated acylated ghrelin upon intake of a HP diet, we investigated the regulation of ghrelin concentrations in plasma and tissues in wethers fed with either the HP diet or the control (CNT) diet for 14 days, and examined the action of the elevated plasma ghrelin by using a ghrelin-receptor antagonist. The HP diet gradually increased the plasma acylated-ghrelin concentrations, but the CNT diet did not. Although the GH concentrations did not vary significantly across the groups, an injection of ghrelinreceptor antagonist enhanced insulin levels in circulation in the HP diet group. In the fundus region of the stomach, the ghrelin levels did not differ between the HP and CNT diet groups, whereas ghrelin O-acyltransferase mRNA levels were higher in the group fed with HP diet than those of the CNT diet group were. These results indicate that the HP diet elevated the plasma ghrelin levels by increasing its synthesis; this elevation strongly suppresses the appearance of insulin in the circulation of wethers, but it is not involved in GH secretion. Overall, our findings indicate a role of endogenous ghrelin action in secretion of insulin, which acts as a regulator after the consumption of a HP diet.

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Enriched protein diet-modified ghrelin expression and secretion in rats

Cited by 26 publications

References 48 publications

Emerging Signaling Pathway in Arcuate Feeding-Related Neurons: Role of the Acbd7

Emerging Signaling Pathway in Arcuate Feeding-Related Neurons: Role of the Acbd7

Macronutrients and obesity: views, news and reviews

Increased plasma ghrelin suppresses insulin release in wethers fed with a high-protein diet

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