Enterobacter spp.: pathogens poised to flourish at the turn of the century.

Sanders, W E; Sanders, C C

doi:10.1128/cmr.10.2.220-241.1997

Cited by 112 publications

(171 citation statements)

References 171 publications

(473 reference statements)

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“…They can be found on plants, particulary fruits and vegetables, as well as on human skin and tissues, insects or water reservoirs (Hoffmann & Roggenkamp, 2003;Neto et al, 2003). Besides Enterobacter aerogenes, E. cloacae is by far the most frequent nosocomial pathogen among Enterobacter species (Sanders & Sanders, 1997). It is responsible for various infections, including bacteremia or lower respiratory tract infections (Sanders & Sanders, 1997).…”

Section: Introductionmentioning

confidence: 99%

“…Besides Enterobacter aerogenes, E. cloacae is by far the most frequent nosocomial pathogen among Enterobacter species (Sanders & Sanders, 1997). It is responsible for various infections, including bacteremia or lower respiratory tract infections (Sanders & Sanders, 1997). The widespread application of antibiotics results in an increased resistance of E. cloacae to antibiotics like ampicillin or narrow-spectrum cephalosporins (Seeberg et al, 1983;Tzelepi et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

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A dual approach employing MALDI-TOF MS and real-time PCR for fast species identification within the Enterobacter cloacae complex

Pavlovic¹,

Konrad²,

Iwobi³

et al. 2012

FEMS Microbiol Lett

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A real-time PCR procedure targeting the gene of the molecular cochaperon DnaJ (dnaJ) was developed for specific detection of strains belonging to the Enterobacter cloacae group. The inclusivity and exclusivity of the real-time PCR assay were assessed with seven reference strains of E. cloacae, 12 other Enterobacter species and 41 non-Enterobacter strains. Inclusivity as well as exclusivity of the duplex real-time PCR was 100%. In contrast, resolution of matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) was inadequate for delineation of Enterobacter asburiae, Enterobacter hormaechei, Enterobacter kobei and Enterobacter ludwigii from E. cloacae. Eleven of 56 (20%) clinical isolates of the E. cloacae group could not be clearly identified as a certain species using MALDI-TOF MS. In summary, the combination of MALDI-TOF MS with the E. cloacae-specific duplex real-time PCR is an appropriate method for identification of the six species of the E. cloacae complex.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A dual approach employing MALDI-TOF MS and real-time PCR for fast species identification within the Enterobacter cloacae complex

Pavlovic¹,

Konrad²,

Iwobi³

et al. 2012

FEMS Microbiol Lett

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“…Strains of Enterobacter cloacae have been implicated as etiological agents of human intestinal and extraintestinal infections that may cause fatal bacteremia, including skin and soft tissues, intra-abdominal, the urinary tract and central nervous system and pneumonia (Sanders & Sanders, 1997). Although E. cloacae is the most common Enterobacter species causing nosocomial infections, little is known about the factors impacting their pathogenicity and virulence.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic activity ofEnterobacter cloacaehuman isolates

Krzymińska

Mokracka

Koczura

et al. 2009

FEMS Immunol Med Microbiol

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We examined 55 Enterobacter cloacae isolates from clinical specimens for the production of cytotonic and cytotoxic toxins and the presence of the type III secretion system (TTSS). Twelve isolates (22%) revealed cytotoxic activity that caused destruction of Vero cells, whereas 28 (51%) strains induced lysis of the murine macrophage J774 cell line. TTSS genes were present in 27% of the isolates. The results indicated that these bacteria may destroy phagocytes and epithelial cells, which may lead to spread within the host.

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“…Enterobacter cloacae is a major nosocomial pathogen, the third most prevalent bacterium isolated in intensive care settings [1]. E. cloacae naturally exhibits resistance to ¢rst and second generation cephalosporins and to aminopenicillins, a mechanism mediated by the production of AmpC, a chromosomal Ambler class C L-lactamase [2].…”

Section: Introductionmentioning

confidence: 99%

Chromosomal ampC genes in Enterobacter species other than Enterobacter cloacae, and ancestral association of the ACT-1 plasmid-encoded cephalosporinase to Enterobacter asburiae

Rottman¹

2002

FEMS Microbiology Letters

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The amplification and sequence of ampC genes in Enterobacter asburiae, Enterobacter cancerogenus, Enterobacter dissolvens, Enterobacter hormaechei and Enterobacter intermedius bring the number of known cephalosporinase sequences from the genus Enterobacter to seven. Expression in Escherichia coli of the ampC genes from E. asburiae, E. hormaechei and E. intermedius established the functional nature of these genes. ampC from E. asburiae shows 96.5% identity to bla ACTÀ1 encoding a plasmid-borne cephalosporinase previously believed to derive from Enterobacter cloacae. The reassignment of ACT-1 ancestry to E. asburiae is confirmed by the 95.5% identity between ampR upstream of bla ACTÀ1 and ampR from E. asburiae. ß

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Enterobacter spp.: pathogens poised to flourish at the turn of the century.

Cited by 112 publications

References 171 publications

A dual approach employing MALDI-TOF MS and real-time PCR for fast species identification within the Enterobacter cloacae complex

A dual approach employing MALDI-TOF MS and real-time PCR for fast species identification within the Enterobacter cloacae complex

Cytotoxic activity ofEnterobacter cloacaehuman isolates

Chromosomal ampC genes in Enterobacter species other than Enterobacter cloacae, and ancestral association of the ACT-1 plasmid-encoded cephalosporinase to Enterobacter asburiae

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