Epidemic Adenoviral Keratoconjunctivitis Possibly Related to Ophthalmological Procedures in a Neonatal Intensive Care Unit: Lessons from an Outbreak

Çalkavur, Şebnem; Olukman, Özgür; Öztürk, Arif; Kılıç, Fatma; Gülfidan, Gamze; Devrim, İlker; Malatyalı, Rana; Oruç, Yeliz; Atlıhan, Füsun

doi:10.3109/09286586.2012.718402

Cited by 20 publications

(18 citation statements)

References 25 publications

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“…Treatment of surfaces with alcohol solutions (85 to 95%) for at least 2 min or with sodium hypochlorite for 10 min is effective at inactivating the virus (83). Efficient decontamination of surfaces is of paramount importance, particularly in transplant and intensive care units, to prevent this mode of transmission in immunosuppressed patients (84). Although exogenous infection by nosocomial or community acquisition in the inpatient setting is a rather rare cause of HAdV-related diseases, outbreaks of infections on hematology or transplant wards as well as in eye clinics, resulting in closures, have been documented (19,85,86,87).…”

Section: Transmissionmentioning

confidence: 99%

Adenovirus Infections in Immunocompetent and Immunocompromised Patients

2014

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SUMMARY Human adenoviruses (HAdVs) are an important cause of infections in both immunocompetent and immunocompromised individuals, and they continue to provide clinical challenges pertaining to diagnostics and treatment. The growing number of HAdV types identified by genomic analysis, as well as the improved understanding of the sites of viral persistence and reactivation, requires continuous adaptions of diagnostic approaches to facilitate timely detection and monitoring of HAdV infections. In view of the clinical relevance of life-threatening HAdV diseases in the immunocompromised setting, there is an urgent need for highly effective treatment modalities lacking major side effects. The present review summarizes the recent progress in the understanding and management of HAdV infections.

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Section: Transmissionmentioning

confidence: 99%

Adenovirus Infections in Immunocompetent and Immunocompromised Patients

2014

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“…It has been previously stated that outbreaks of AVC in NICU were commonly manifested after ophthalmological examination procedures due to contaminated instruments [9, 11]. Low BW and patient care factors were also shown to be other causes of conjunctivitis among preterm infants [14].…”

Section: Discussionmentioning

confidence: 99%

“…Various studies reported outbreaks due to adenovirus infections at neonatal intensive care unit (NICU). Also the association between AVC and ROP examinations has been previously published [9–11]. …”

Section: Introductionmentioning

confidence: 99%

Treatment for Retinopathy of Prematurity in an Infant with Adenoviral Conjunctivitis

Günay

Çelik

Con

2015

Case Reports in Pediatrics

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Retinopathy of prematurity (ROP) has been a major problematic disorder during childhood. Laser photocoagulation (LPC) has been proven to be effective in most of the ROP cases. Adenoviral conjunctivitis (AVC) is responsible for epidemics among adult and pediatric population. It has also been reported to be a cause of outbreaks in neonatal intensive care units (NICU) several times. We herein demonstrate a case with AVC who underwent LPC for ROP. And we discuss the treatment methodology in such cases.

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“…Это связано в первую очередь с увеличением число офталь-мологических осмотров и манипуляций при развитии оф-тальмологической службы в перинатальных центрах [6,7]. К сожалению, трудности в изоляции детей, невозмож-ность выписать ребенка на долечивание домой, плохая информированность медицинского персонала о высокой контагиозности инфекции и недостаток знаний о мерах профилактики заболевания, приводит к быстрому рас-пространению инфекции внутри учреждения.…”

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Features of the Clinical Course, Observation and Prevention of Adenoviral Epidemic Keratoconjunctivitis in Infant in the Perinatal Center

Astasheva¹

2017

Det. infekc.

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Особенности клинического течения, наблюдения и профилактики аденовирусного эпидемического кератоконъюнктивита у детей первых месяцев жизни в условиях перинатального центра И. Б. АСТАШЕВА ГБОУ ВПО Российский национальный исследовательский медицинский университет имени Н.И. Пирогова Минздрава России, Москва, Россия В последние годы увеличилось число случаев аденовирусного эпидемического кератоконъюнктивита (ЭКК) в перина-тальных центрах, что связано в первую очередь с увеличением числа офтальмологических осмотров и манипуляций. Цель: охарактеризовать особенности течения и выявить наиболее эффективные методы профилактики аденовирусного ЭКК у детей первых месяцев жизни, находящихся на выхаживании и лечении в перинатальных центрах. Аденовирусный ЭКК диагностирован у 284 детей в возрасте от 2 суток до 3 месяцев, находящихся на выхаживании в перинатальных центрах г. Москвы. У 165 детей с ЭКК отмечалась ретинопатия недоношенных (РН). Течение аденови-русного ЭКК у детей раннего возраста сопровождалось отеком век, конъюнктивы, образованием пленчатых мембран (49,3%), геморрагиями (69,7%), отеком роговицы (30,3%), отсутствием фолликулеза конъюнктивы век. Инфильтраты роговицы встречались в 1,9% случаев и всегда исчезали через 1-2 нед. после появления. Развитие аденовирусного ЭКК у недоношенных детей на фоне ретинопатии недоношенных (РН) осложняет ее течение. Эффективность лазерко-агуляции у детей с РН такая же, что и у детей без конъюнктивита и составляет 97,2%. Проведение криокоагуляции на пике течения конъюнктивита, по нашим данным, малоэффективно, стабилизация РН не превышает 50%. Соблюдение тщательных мер профилактики аденовирусного ЭКК позволило сократить продолжительность вспышки до 1 мес. Течение аденовирусного ЭКК у детей первых месяцев жизни тяжелое, однако в исходе ни у одного ребенка не отмеча-лось осложнений (длительно существующих инфильтратов роговицы, спаек конъюнктитвы). Ключевые слова: аденовирусный эпидемический кератоконъюнктивит, перинатальный центр, ретинопатия недоно-шенных In recent years, the number of adenoviral epidemic keratoconjunctivitis (EKC) cases in a neonatal intensive care unit (NICU) has increased, which is primarily due to the establishment of an ophthalmologic service in these institutions, and the increase of the number of ophthalmologic examinations and manipulations. To characterize the features of the course and to identify the most effective methods of preventing adenoviral EKC of children during the first months of life who are on care and treatment in NICU. Adenoviral EKC is diagnosed in 284 children aged from 2 days to 3 months, who are on nursing in perinatal centers of Moscow. In 165 children with EKC retinopathy of prematurity (ROP) was noted. The course of adenoviral EKC in children in the age of the first months was accompanied by eyelids edema and conjunctiva edema, the formation of membranes (49.3%), hemorrhages (69.7%), corneal edema (30.3%), and absence of folliculosis of the eyelid conjunctiva. Cornea infiltrates occurred in 1.9% of cases and always disappeared in 1-2 we...

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Epidemic Adenoviral Keratoconjunctivitis Possibly Related to Ophthalmological Procedures in a Neonatal Intensive Care Unit: Lessons from an Outbreak

Cited by 20 publications

References 25 publications

Adenovirus Infections in Immunocompetent and Immunocompromised Patients

Adenovirus Infections in Immunocompetent and Immunocompromised Patients

Treatment for Retinopathy of Prematurity in an Infant with Adenoviral Conjunctivitis

Features of the Clinical Course, Observation and Prevention of Adenoviral Epidemic Keratoconjunctivitis in Infant in the Perinatal Center

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