Epidemiological Assessments of Skin Outcomes in the Nurses’ Health Studies

Li, Wen-Qing; Cho, Eunyoung; Weinstock, Martin A.; Hasan, Mashfiq; Qureshi, Abrar A.

doi:10.2105/ajph.2016.303315

Cited by 30 publications

(44 citation statements)

References 44 publications

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“…This study included participants from the ongoing NHS and NHSII cohorts (Li et al, 2016;Thompson et al, 2016). NHS was established in 1976 when 121,700 female nurses aged 30 to 55 years responded to a baseline questionnaire inquiring about lifestyle factors and medical history.…”

Section: Methodsmentioning

confidence: 99%

Race and Alopecia Areata amongst US Women

Thompson

Park

Qureshi

et al. 2018

Journal of Investigative Dermatology Symposium Proceedings

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Few studies have examined the clinical epidemiology of alopecia areata (AA) in regard to patient race, and therefore, any disparities in incidence or prevalence of disease are largely unexplored. We sought to investigate potential racial disparities amongst two large cohorts of women. We conducted a cross-sectional analysis from the Nurses' Health Study (NHS) and Nurses' Health Study II (NHSII), wherein participants self-reported a diagnosis of AA. We determined odds ratios for AA by race in a multivariate analysis. Among 63,960 women from NHS and 88,368 women from NHSII with information on race and diagnosis of AA, we identified 418 and 738 cases of AA, respectively. In NHS, the multivariate-adjusted odds ratio for AA was 2.72 (95% confidence interval 1.61-4.61) amongst black women as compared with white women. In NHSII, the multivariate-adjusted odds ratio was 5.48 (95% confidence interval 4.10-7.32) amongst black as compared with white women. In a secondary analysis designating participants by Hispanic ethnicity, in NHSII the multivariate odds ratio was 1.94 (95% CI 1.24-3.02) in Hispanic compared with non-Hispanic white women. In this study, we found increased odds of AA based on self-reported race in black and Hispanic women as compared with white women. Further studies are needed to explore the mechanism of this racial disparity related to AA.

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Section: Methodsmentioning

confidence: 99%

Race and Alopecia Areata amongst US Women

Thompson

Park

Qureshi

et al. 2018

Journal of Investigative Dermatology Symposium Proceedings

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“…15,16 Information on alcohol use was collected in 1991, 1995, 1999, and 2003. Women in NHS II were asked how often, on average, they had consumed regular beer, light beer (12 oz.…”

Section: Methodsmentioning

confidence: 99%

Alcohol intake and risk of rosacea in US women

Cho

Drucker

et al. 2017

Journal of the American Academy of Dermatology

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Background The epidemiologic association between alcohol and rosacea is unclear and inconsistent based on prior cross-sectional or case-control studies. Objective We conducted a cohort study to determine the association between alcohol intake and the risk of incident rosacea. Methods A total of 82,737 women were included from the Nurses’ Health Study II (1991–2005). Information on alcohol intake was collected every four years during follow-up. Information on history of clinician-diagnosed rosacea and year of diagnosis was collected in 2005. Results Over 14 years of follow-up, we identified 4,945 incident cases of rosacea. Compared with never drinkers, increased alcohol intake was associated with a significantly elevated risk of incident rosacea (P for trend<0.0001). The multivariable-adjusted HRs (95% CIs) were 1.12 (95% CI 1.05–1.20) for alcohol intake of 1–4 g/day, and 1.53 (1.26–1.84) for ≥30 g/day. The associations remained consistent across categories of smoking status. Further examination of types of alcoholic beverage consumed revealed that white wine (P for trend <0.0001) and liquor intake (P for trend =0.0006) were significantly associated with higher risk of rosacea. Limitations This was an epidemiologic study without examination into etiologic mechanisms. Conclusions Alcohol intake was significantly associated with an increased risk of incident rosacea in women.

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“…The increased melanin barrier in darker-pigmented individuals decreases both ultraviolet (UV) A and B radiation through the skin (38)(39)(40). UV radiation is known to induce both cell death and malignant transformation of skin cells; it is considered the paramount risk factor for melanoma (41)(42)(43)(44)(45)(46). Compared to fairer-skinned people, UVB radiation through the epidermis is diminished by approximately 50% in darker-skinned people (38), and UVA transmission through the dermis decreases from 27 to 4% at 314 nm and 47 to 14% at 400 nm (39).…”

Section: Ethnicitymentioning

confidence: 99%

“…Overall, men are more susceptible to melanoma. Some posit that this increased susceptibility seen among men may be in part androgen driven (43,72,73). This difference in incidence by sex is exemplified in the United States with annual incidence ASRs of 29.2:100,000 cases in men compared to 17.3:100,000 cases in women (6).…”

Section: Sexmentioning

confidence: 99%

Epidemiology of Melanoma

Matthews

Qureshi

et al. 2017

Cutaneous Melanoma: Etiology and Therapy

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Melanoma is a potentially lethal cancer that is most commonly cutaneous. The worldwide incidence of melanoma has risen rapidly over the course of the last 50 years. Its incidence is greatest among fair-skinned populations, and in regions of lower latitude. Incidence is greater among geriatric populations, but melanoma is also among the most common cancers found in adolescent and young adult populations. In fact, it is one of the leading cancers in average years of life lost per death from disease. Melanoma incidence varies by sex, which is also associated with differences in melanoma anatomic site. Similar differences by region, ethnicity, age, and sex are observed in mortality rates of melanoma. In the setting of rising incidence and mortality, melanoma bears a heavy health and economic burden. Attributable costs are several billion in nations with greater melanoma incidence. Preventative strategies have been implemented in multiple high-risk regions with variable success. It is imperative that research efforts Epidemiology of Melanoma 4 achieve better understanding of the risk factors and etiology of disease, with the goal to halt and reverse the progressive trend of rising incidence and mortality from melanoma.

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Epidemiological Assessments of Skin Outcomes in the Nurses’ Health Studies

Cited by 30 publications

References 44 publications

Race and Alopecia Areata amongst US Women

Race and Alopecia Areata amongst US Women

Alcohol intake and risk of rosacea in US women

Epidemiology of Melanoma

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