Epidemiology of Heart Failure and Scope of the Problem

Tead1 is required for maintaining adult cardiomyocyte function, and its loss results in lethal dilated cardiomyopathy

“…Heart failure is a global health problem affecting more than 25 million people worldwide, including 5.7 million adults in the United States (1). Dilated cardiomyopathy (DCM) -a form of heart failure with diminished cardiac contractility, dilated ventricular chambers, myocyte death, and myocardial fibrosis (2) -has a has a prevalence of 1 in 2,500 (3, 4) and a high 5-year mortality of 50% (4).…”

Assessment of the role of matrix metalloproteinase-2 gene polymorphism in the development of chronic heart failure

“…В Российской Федерации среди всех пациен-тов, направленных на стационарное лечение с сердечно-сосудистыми заболеваниями (ССЗ), ХСН (по Фрамин-гемским критериям) явилась основной причиной госпи-тализации в 16,8% случаев [1,2]. Отдаленный прогноз выживаемости больных с ХСН во многом зависит от вы-раженности клинических проявлений, структурных и функциональных поражений миокарда, проводимой те-рапии, а также от степени ограничения физической ак-тивности, которая определяет функциональный класс (ФК) [3,4]. Среди пациентов с ХСН I-IV ФК средняя го-дичная смертность составляет 6% [5].…”

A service improvement ‘tool kit’ for effective heart failure management in primary care

“…Education alone is insufficient in promoting change as barriers and enablers to change exist at both organisational and individual levels [10]. Barriers to the implementation of best evidence in HF diagnosis and management in general practice include a lack of a confidence amongst health professionals around HF diagnosis and management compounded by a lack of awareness about current evidence; a scenario that appears to have altered very little over time [7].…”