Currently, fractures of the middle face area remain a serious problem of maxillofacial traumatology because there is not only an increase in the number of injuries to the bones of the facial skull, but also the sever character of these injuries, and an increasing number of post-traumatic complications. This is due to the increase in crime, alcoholism, the proliferation of weapons among the population, the increase in traffic accidents, and injuries in the war zone. The purpose of the study was a retrospective analysis of the features of the damage to the middle face area of patients in a large industrial region. Material and methods. We conducted a retrospective analysis of the injury features of the middle face area in 416 patients who became patients of the department of head and neck surgery for the period from January 1, 2010 to December 31, 2019. Results and discussion. The study results showed that the vast majority (χ2 = 529.9; F = 0.000000; p <0.05) of patients were male. Men had by 79.3 (OR = 79.29; F = 0.000000) times higher risk of middle face injury than women. The risk of traumatic face injury in women increased with the age. Thus, in the group of women aged 61+ it was by 29.6 times higher than in the group of women aged 21-30 (OR = 29.6; F = 0.003203). The greatest number of injuries was observed in the age group of 21-30 years. Assessment of the injury risk in this age group showed that it was by 35.5 times higher than in the group of patients aged 61+ and by 2.1 times higher than in the group aged 31-40. Conclusion. The main etiological factor of injuries of the middle face area was domestic trauma, which was 369 (88.7±1.5)% of cases, which was significantly more (χ2 = 498.5; F = 0.000000; p <0.05) than other types of injuries. The risk of domestic injury was by 61.6 times higher than other types of injury. The study results proved that criminal injuries had the highest frequency among all types of injuries (50% of all types of injuries), fall injury was on second place (38%), and road accidents injuries were on third place (7%). A significant majority of the middle face injuries had men, the number of women with injuries of the middle face area increased significantly with the age. The largest number of patients (71.4%) with injuries of the middle face area occurred in the age groups 21-30 and 31-40, that is people of working age