(-)-Epigallocatechin-3-Gallate Induces Apoptosis and Inhibits Invasion and Migration of Human Cervical Cancer Cells

Sharma, Chhavi; Nusri, Qurrat El-Ain; Begum, Salema; Javed, Elham; Rizvi, Tahir A.; Hussain, Arif

doi:10.7314/apjcp.2012.13.9.4815

Cited by 61 publications

(51 citation statements)

References 57 publications

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“…These secondary metabolites can act on almost all stages of carcinogenesis including initiation, promotion and progression, and may also interfere with chemo-and radiotherapy in patients undergoing cancer treatment (Di Domenico et al, 2012;Hussain et al, 2012;Sharma et al, 2012). Besides the diverse and complex biological effects such dietary compounds are generally relatively safe exerting lower toxicity and fewer side effects than traditional chemotherapeutic agents (Tudoran et al, 2012;Kim and Kim., 2013;Muthusami et al, 2013).…”

Section: Natural Flavonoids As a Potential Source For Novel Chemothermentioning

confidence: 99%

“…The anticancer action of EGCG includes numerous mechanisms and occurs via various pathways depending on the nature and origin of the cells (Sah et al, 2004;Butler and Wu, 2011;Muthusami et al, 2013). Thus, the antiproliferative activity of EGCG is described in both HPV-positive as well as HPV-negative human cervical cancer cell lines (see Table 2) and this polyphenolic compound could induce the cell cycle arrest and/or promote apoptosis in HPV16-associated CaSki cells (Ahn et al, 2003a;Qiao et al, 2009;Di Domenico et al, 2012), HPV18-positive HeLa and TMCC-1 cells (Borska et al, 2003;Yang et al, 2003;Noguchi et al, 2006;Qiao et al, 2009;Sharma et al, 2012;Muthusami et al, 2013) but also in HPV-negative OMC-4 cells (Noguchi et al, 2006). In CaSki and HeLa cells EGCG can cause reduction in oncoproteins E6 and E7 expression leading to increase in p53 protein and suppression of cancer cell growth (Qiao et al, 2009;Zou et al, 2010).…”

Section: Flavanolsmentioning

confidence: 99%

“…In CaSki and HeLa cells EGCG can cause reduction in oncoproteins E6 and E7 expression leading to increase in p53 protein and suppression of cancer cell growth (Qiao et al, 2009;Zou et al, 2010). Moreover, EGCG is also able to effectively inhibit the invasion and migration of HeLa cells by modulating the expression of related genes and impeding the metastasis process (Zhang Q et al, 2006;Sharma et al, 2012;Tudoran et al, 2012).…”

Section: Flavanolsmentioning

confidence: 99%

“…Considering the aforementioned knowledge and the relatively low toxicity and effective oral bioavailability of green tea constituent EGCG, it is evident that this compound holds a great potential in the treatment of cervical cancer, both from the preventive as well as therapeutic aspects, and EGCG could be regarded as a promising candidate for the development of novel anticancer drugs (Ahn et al, 2003b;Di Domenico et al, 2012;Sharma et al, 2012;Muthusami et al, 2013).…”

Section: Flavanolsmentioning

confidence: 99%

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Characteristic Features of Cytotoxic Activity of Flavonoids on Human Cervical Cancer Cells

Sak¹

2014

Asian Pacific Journal of Cancer Prevention

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Cervical cancer is the most common gynecologic malignancy worldwide and development of new therapeutic strategies and anticancer agents is an urgent priority. Plants have remained an important source in the search for novel cytotoxic compounds and several polyphenolic flavonoids possess antitumor properties. In this review article, data about potential anticarcinogenic activity of common natural flavonoids on various human cervical cancer cell lines are compiled and analyzed showing perspectives for the use of these secondary metabolites in the treatment of cervical carcinoma as well as in the development of novel chemotherapeutic drugs. Such anticancer effects of flavonoids seem to differentially depend on the cellular type and origin of cervical carcinoma creating possibilities for specific targeting in the future. Besides the cytotoxic activity per se, several flavonoids can also contribute to the increase in efficacy of conventional therapies rendering tumor cells more sensitive to standard chemotherapeutics and irradiation. Although the current knowledge is still rather scarce and further studies are certainly needed, it is clear that natural flavonoids may have a great potential to benefit cervical cancer patients.

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Section: Natural Flavonoids As a Potential Source For Novel Chemothermentioning

confidence: 99%

Section: Flavanolsmentioning

confidence: 99%

Section: Flavanolsmentioning

confidence: 99%

Section: Flavanolsmentioning

confidence: 99%

See 2 more Smart Citations

Characteristic Features of Cytotoxic Activity of Flavonoids on Human Cervical Cancer Cells

Sak¹

2014

Asian Pacific Journal of Cancer Prevention

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“…To develop effective therapy methdod for cervical cancer is urgent and essential (Wongwatcharanukul et al, 2014;McRae et al, 2014). Chemotherapy is a necessary component of the treatment (Sharma et al, 2012). Chemotherapy agents with considerable efficacy play a key role in treatment.…”

Section: Discussionmentioning

confidence: 99%

Preliminary Evaluation of the in vitro Efficacy of 1, 2-di (Quinazolin-4-yl) Diselane against SiHa Cervical Cancer Cells

Huang

Zhang²,

Liu³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Cervical cancer is one the most common malignancies among females. In recent years, its incidence rate has shown a rising trend in some countries so that development of anticancer drugs for cervical cancer is an urgent priority. In our recent anticancer drug discovery screen, 1, 2-di (quinazolin-4-yl)diselane (LG003) was found to possess wide spectrum anticancer efficacy. In the present work, the in vitro anticancer activity of LG003 was evaluated in the SiHa cervical cancer cell line. Compared with commercial anticancer drugs 10-hydroxycamptothecin, epirubicin hydrochloride, taxol and oxaliplatin, LG003 showed better anticancer activity. Furthermore, inhibition effects were time-and dose-dependent. Morphological observation exhibited LG003 treatment results in apoptosis like shrinking and blebbing, and cell membrane damage. Lactate dehydrogenase release assay revealed that LG003 exerts such effects in SiHa cells through a physiology pathway rather than cytotoxicity, which suggests that title compound LG003 can be a potential candidate agent for cervical cancer.

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LncRNA TUSC8 inhibits the invasion and migration of cervical cancer cells via miR‐641/PTEN axis

Zhu

Liu

Zhang

et al. 2019

Cell Biology International

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Cervical cancer (CC) is the fourth leading cause of cancer‐related death in women worldwide. There is an urgent need to find novel targets for the treatment of CC. Recently, microRNA have emerged as critical factors in tumorigenesis. In this study, we aimed to investigate the mechanism of miR‐641 on the migration and invasion of CC cells. In silico analysis revealed putative interaction between miR‐641 and phosphatase and tensin homolog (PTEN) RNA/lncRNA tumor suppressor candidate 8 (TUSC8). Hence we evaluated the expression of TUSC8, miR‐641, and PTEN. We found that the expressions of TUSC8 and PTEN were decreased in CC tissues, whereas miR‐641 expression was increased. Inhibition of miR‐641 suppressed the migration and invasion of Hela cells. In addition, TUSC8 and PTEN were upstream and downstream target molecule of miR‐641, respectively. Overexpression of TUSC8 promoted PTEN expression, and suppressed the invasion and migration of Hela cells, whereas miR‐641 mimic treatment changed the effects. These results demonstrated that overexpression of TUSC8 could inhibit the invasion and migration of CC cells by upregulating PTEN via miR‐641.

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(-)-Epigallocatechin-3-Gallate Induces Apoptosis and Inhibits Invasion and Migration of Human Cervical Cancer Cells

Cited by 61 publications

References 57 publications

Characteristic Features of Cytotoxic Activity of Flavonoids on Human Cervical Cancer Cells

Characteristic Features of Cytotoxic Activity of Flavonoids on Human Cervical Cancer Cells

Preliminary Evaluation of the in vitro Efficacy of 1, 2-di (Quinazolin-4-yl) Diselane against SiHa Cervical Cancer Cells

LncRNA TUSC8 inhibits the invasion and migration of cervical cancer cells via miR‐641/PTEN axis

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