Epigenetics and obesity cardiomyopathy: From pathophysiology to prevention and management

Zhang, Yingmei; Ren, Jun

doi:10.1016/j.pharmthera.2016.03.005

Cited by 100 publications

(53 citation statements)

References 181 publications

(168 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Essentially, there are two types of approaches for which this can be achieved: digestion-and antibody-based techniques [31] . It has been determined that the enzyme glucosyltransferase will modify 5-hmC, but not 5 mCbases.…”

Section: Detection Of Hydroxymethyl Cytosinementioning

confidence: 99%

“…It has been determined that the enzyme glucosyltransferase will modify 5-hmC, but not 5 mCbases. Based on this intrinsic difference in their properties as substrates, both New England Bio labs and Zymo Research have developed assay kits for the specific detection of glycosylated 5-hmC.Zymo Research's Quest hmC Detection Kit utilizes hydroxymethylcytosine glucosyltransferase and the substrate uridine diphosphoglucose to selectively glucosylate 5-hmC bases [31] . Importantly, modification of the 5-hmC bases renders these sites of the DNA strand resistant to cleavage by the nuclease MspI.…”

Section: Detection Of Hydroxymethyl Cytosinementioning

confidence: 99%

“…Enrichment for 5-hmC-containing DNA could be done with anti-5-hmC antibodies. They are available from several companies [31] .…”

Section: Detection Of Hydroxymethyl Cytosinementioning

confidence: 99%

See 2 more Smart Citations

Epigenetic Modification of Ten Eleven Translocase Enzyme Mediated Hydroxymethylcytosine in Brain Derived Neurotrophic Factor for the Pathogenesis of Type II Diabetes Retinopathy

Tripathi¹

2017

JMSCR

View full text Add to dashboard Cite

show abstract

Section: Detection Of Hydroxymethyl Cytosinementioning

confidence: 99%

Section: Detection Of Hydroxymethyl Cytosinementioning

confidence: 99%

See 1 more Smart Citation

Epigenetic Modification of Ten Eleven Translocase Enzyme Mediated Hydroxymethylcytosine in Brain Derived Neurotrophic Factor for the Pathogenesis of Type II Diabetes Retinopathy

Tripathi¹

2017

JMSCR

View full text Add to dashboard Cite

show abstract

“…To create therapies that are effective in CAD treatment, it is of most importance to improve our understanding of numerous genetic, as well as epigenetic cues for the onset and development of heart failure [5,6]. …”

Section: Introductionmentioning

confidence: 99%

Genetic Markers for Coronary Artery Disease

et al. 2018

View full text Add to dashboard Cite

Coronary artery disease (CAD) and myocardial infarction (MI) are recognized as leading causes of mortality in developed countries. Although typically associated with behavioral risk factors, such as smoking, sedentary lifestyle, and poor dietary habits, such vascular phenotypes have also long been recognized as being related to genetic background. We review the currently available data concerning genetic markers for CAD in English and non-English articles with English abstracts published between 2003 and 2018. As genetic testing is increasingly available, it may be possible to identify adequate genetic markers representing the risk profile and to use them in a clinical setting.

show abstract

“…Many fine studies have shown the influence of environment on DNA for embryonic development; but also for the future development of obesity or diabetes, for the development of stress responses, of hypertension or cancer. Therefore epigenetic modifications are to be considered an important mechanism in the etiology of many diseases since the prenatal life [8]. Such induced epigenetic changes can be inherited during cell division in the first phases of life, namely in the first part of the golden 1,000 days, resulting in permanent conservation of the acquired phenotype.…”

Section: Introductionmentioning

confidence: 99%

The Golden 1,000 Days

Bellieni¹

2016

J Gen Pract

View full text Add to dashboard Cite

The first 1,000 days, from conception to the end of the second year after birth, are crucial for the future of any human being. They are crucial for health, for the development of diseases, for learning. In this process, epigenetics and precocious sensory development are the principal routes. Several organizations throughout the globe have highlighted the importance of these 1,000 days. The "1,000 Days" initiative was born in 2010 with the backing of the U.S. Government, the Government of Ireland and several nonprofit organizations, and drove greater action and investment to improve nutrition for women and young children throughout the world. This and similar initiatives aim to improve nutrition in developing and in industrialized countries, where problems are different, but the first 1,000 days are equally crucial; these initiatives are highlighted in the text.

show abstract

Epigenetics and obesity cardiomyopathy: From pathophysiology to prevention and management

Cited by 100 publications

References 181 publications

Epigenetic Modification of Ten Eleven Translocase Enzyme Mediated Hydroxymethylcytosine in Brain Derived Neurotrophic Factor for the Pathogenesis of Type II Diabetes Retinopathy

Epigenetic Modification of Ten Eleven Translocase Enzyme Mediated Hydroxymethylcytosine in Brain Derived Neurotrophic Factor for the Pathogenesis of Type II Diabetes Retinopathy

Genetic Markers for Coronary Artery Disease

The Golden 1,000 Days

Contact Info

Product

Resources

About